The Complex Role of Vitamin D in Autoimmune Diseases

Szodoray, Péter; Nakken, Britt; Gaál, János; Jönsson, Roland; Szegedi, Andrea; Zöld, Éva; Szegedi, Gyula; Brun, Johan G.; Gesztelyi, Rudolf; Zeher, Margit; Bodolay, Edit

doi:10.1111/j.1365-3083.2008.02127.x

Cited by 195 publications

(142 citation statements)

References 84 publications

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“…Inadequate vitamin D intake is linked to a higher incidence of autoimmune disorders (66,67). Vitamin D exerts its action via VDR which is expressed in a wide variety of tissues, also on lymphocytes, monocytes, and dendritic cells (65,68).…”

Section: The Role Of Vitamin D Deficiencymentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

Gaberšček

Zaletel

Schwetz

et al. 2015

European Journal of Endocrinology

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Thyroid disorders, especially Hashimoto's thyroiditis (HT), and polycystic ovary syndrome (PCOS) are closely associated, based on a number of studies showing a significantly higher prevalence of HT in women with PCOS than in controls. However, the mechanisms of this association are not as clear. Certainly, genetic susceptibility contributes an important part to the development of HT and PCOS. However, a common genetic background has not yet been established. Polymorphisms of the PCOS-related gene for fibrillin 3 (FBN3) could be involved in the pathogenesis of HT and PCOS. Fibrillins influence the activity of transforming growth factor beta (TGFb). Multifunctional TGFb is also a key regulator of immune tolerance by stimulating regulatory T cells (Tregs), which are known to inhibit excessive immune response. With lower TGFb and Treg levels, the autoimmune processes, well known in HT and assumed in PCOS, might develop. In fact, lower levels of TGFb1 were found in HT as well as in PCOS women carrying allele 8 of D19S884 in the FBN3 gene. Additionally, vitamin D deficiency was shown to decrease Tregs. Finally, high estrogen-to-progesterone ratio owing to anovulatory cycles in PCOS women could enhance the immune response. Harmful metabolic and reproductive effects were shown to be more pronounced in women with HT and PCOS when compared with women with HT alone or with controls. In conclusion, HT and PCOS are associated not only with respect to their prevalence, but also with regard to etiology and clinical consequences. However, a possible crosstalk of this association is yet to be elucidated.

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Section: The Role Of Vitamin D Deficiencymentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

Gaberšček

Zaletel

Schwetz

et al. 2015

European Journal of Endocrinology

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“…In more recent years, the actions of vitamin D have been shown to go beyond calcium metabolism to include cell growth, differentiation, maturation and apoptosis, anticarcinogenic effects, and anti-autoimmune activities (2,3). In particular, the role of vitamin D as an immune modulator has been emphasized in recent reports (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

“…Vitamin D deficiency has been found to correlate with an increased incidence of autoimmune diseases, including type 1 diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis (MS), and Crohn's disease (2)(3)(4)(5)(6)(7). In some animal experiments, vitamin D supplements prevented the development and progression of autoimmune disorders such as MS and type 1 diabetes mellitus (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Low Levels of Serum Vitamin D3 Are Associated with Autoimmune Thyroid Disease in Pre-Menopausal Women

Choi

Kim

et al. 2014

Thyroid

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Background: Low serum vitamin D levels have been associated with several autoimmune diseases, but their association with thyroid autoimmunity is unclear. We evaluated the association of serum vitamin D levels with the prevalence of autoimmune thyroid disease (AITD). Methods: Our cross-sectional study included subjects who underwent routine health checkups, which included assays of serum 25-hydroxy vitamin D3 [25(OH)D3] and anti-thyroid peroxidase antibody (TPO-Ab), as well as thyroid ultrasonography (US) between 2008 and 2012 at the Asan Medical Center. We defined AITD according to the levels of TPO-Ab and US findings. Results: A total of 6685 subjects (58% male; 42% female) were enrolled for this study. Overall prevalence of TPO-Ab positivity and both TPO-Ab/US positivity were 10.1% (6.3% male; 15.3% female) and 5.4% (2.3% male; 9.7% female) respectively. In female subjects, mean serum 25(OH)D3 levels were significantly lower in the TPO-Ab(+) (22.0 vs. 23.5 ng/mL, p = 0.030) and TPO-Ab(+)/US(+) groups (21.6 vs. 23.4 ng/mL, p = 0.027) compared with the control group, respectively. According to the levels of serum 25(OH)D3, the prevalence of TPO-Ab positivity (21.2%, 15.5%, and 12.6% in deficient, insufficient, and sufficient group, respectively; p = 0.001) and both TPO-Ab and US positivity (14.7%, 9.9%, and 7.1% in deficient, insufficient, and sufficient group, respectively; p < 0.001) decreased in female subjects. Interestingly, this pattern was significant only in pre-menopausal women ( p = 0.003 and p < 0.001; respectively), but not in postmenopausal women. Multivariate analysis indicated that the adjusted odds ratios (

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“…In recent years, the role of vitamin D in not only calcium and phosphorus homeostasis and bone metabolism, but also immune system function, has been well established (27,28), and the 1,25(OH)2D3 vitamin and its homologues suppress autoimmunity by modulating both the antigen-presenting cells and T-cells (29,30 (33). While some studies show a significant relationship between vitamin D and disease activity, others argue otherwise.…”

Section: Discussionmentioning

confidence: 99%

Relation Between Osteoporosis and Vitamin D Levels and Disease Activity in Psoriatic Arthritis

Oten¹,

Başkan²,

Sivas³

et al. 2017

Erciyes Med J

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Objective: This study investigated the relation between osteoporosis and vitamin D levels and the disease activity in patients with psoriatic arthritis (PsA). Materials and methods:In this study, 58 patients with PsA and 58 healthy controls were included. Bone mineral density (BMD) measurements of patients and controls were performed using dual-energy X-ray absorptiometry. Complete blood count, serum 25(OH)D3, parathormone, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), total calcium, ionized calcium, and phosphorous levels of all participants were measured. Disease activity was evaluated using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Disease Activity Index for Reactive Arthritis (DAREA), and the Disease Activity Score 28 (DAS28). The functional status was evaluated using the Health Assessment Questionnaire for the spondyloarthropathies (HAQ-S), and enthesopathy was evaluated using the Maastricht Ankylosing Spondylitis Enthesitis Score (MASES).Results: BMD values of the patients were significantly lower than those of the controls. There was a negative but statistically insignificant relationship between the lateral lumbar BMD values of the patients and clinical activity signs. Vitamin D levels of the patients were significantly lower than those of the controls. Although there was no correlation between vitamin D levels and ESR and CRP levels, a negative but statistically insignificant relation was found between vitamin D levels and BASDAI, DAREA, and DAS28. The level of CRP, BASDAI, MASES, DAREA, HAQ-S, and DAS28 scores were higher in the patients with osteoporosis; however, none of the differences were statistically significant. Conclusion:In this study, the incidence of osteoporosis was higher and vitamin D levels were lower in patients than in controls.

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The Complex Role of Vitamin D in Autoimmune Diseases

Cited by 195 publications

References 84 publications

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

Low Levels of Serum Vitamin D3 Are Associated with Autoimmune Thyroid Disease in Pre-Menopausal Women

Relation Between Osteoporosis and Vitamin D Levels and Disease Activity in Psoriatic Arthritis

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