Low Levels of Serum Vitamin D3 Are Associated with Autoimmune Thyroid Disease in Pre-Menopausal Women

Choi, Yun Ju; Kim, Won Gu; Kim, Tae Yong; Bae, Sung Jin; Kim, Hong‐Kyu; Jang, Eun Kyung; Jeon, Min Ji; Han, Ji Min; Lee, Seung Hun; Baek, Jung Hwan; Shong, Young Kee; Kim, Won

doi:10.1089/thy.2013.0460

Cited by 81 publications

(77 citation statements)

References 34 publications

(48 reference statements)

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“…6 Other studies also showed lower serum 25(OH)D levels or a higher prevalence of vitamin D insufficiency in AITD or HT 9,10 and a negative correlation between 25(OH) D and TPO-Ab levels in AITD or HT. 9,14,22 In a recent Chinese population-based health survey, a negative correlation was found between 25(OH)D levels and Tg-Ab levels in female individuals. 23 Additionally, a few studies have reported an inverse relationship between 25(OH)D and TSH levels or severity in HT, as in the present study, suggesting the association between low vitamin D status and progressive thyrocyte damage.…”

Section: Discussionmentioning

confidence: 99%

“…25 The present study reported a relatively high mean vitamin D level and low prevalence of vitamin D insufficiency and deficiency compared to other Korean population-based studies. 22,30 One of the Korean studies reported that the mean serum level of 25(OH)D was 52.9 nmol/L (21.2 ng/mL) in males (aged 10-91 years) and 45.4 nmol/L (18.2 ng/mL) in females ranging in age from 10-93 years, while vitamin D insufficiency/deficiency was found in 86.8%/47.3% of males and 93.3%/64.5% of females by the Fourth Korea National Health and Nutrition Examination Surveys in the Korean population in 2008. 30 In the current study, adult patients who visited a tertiary hospital for thyroid evaluation or follow-up were enrolled.…”

Section: Discussionmentioning

confidence: 99%

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Low vitamin D status is associated with hypothyroid Hashimoto’s thyroiditis

Kim¹

2016

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Low vitamin D status is associated with hypothyroid Hashimoto’s thyroiditis

Kim¹

2016

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“…As previously described (16), serum TSH levels were measured using the TSH-CTK-3a radioimmunoassay (RIA; DiaSorin SpA, Saluggia, Italy) with a functional sensitivity of 0.07 mIU/L. Serum fT4 levels were determined using the fT4 RIA (Immunotech, Prague, Czech Republic).…”

Section: Laboratory Measurementsmentioning

confidence: 99%

Clinical Features of Early and Late Postoperative Hypothyroidism After Lobectomy

Park¹,

Jeon²,

Song³

et al. 2017

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context: Lobectomy is preferred in thyroid cancer to decrease surgical complications and avoid lifelong thyroid-hormone replacement. However, postoperative hypothyroidism, requiring thyroidhormone replacement, may occur.Objective: We aimed to identify the incidence and risk factors of postoperative hypothyroidism to develop a surveillance strategy after lobectomy for papillary thyroid microcarcinoma (PTMC).Methods: This historical cohort study involved 335 patients with PTMC treated by lobectomy. Postoperative thyroid functions were measured regularly, and patients were prescribed levothyroxine according to specific criteria. Patients not satisfying hormone-replacement criteria were closely followed up.Results: Postoperative hypothyroidism occurred in 215 patients (64.2%) including 5 (1.5%) with overt hypothyroidism and 210 (62.7%) with subclinical hypothyroidism. Forty patients (11.9%) were required thyroid hormone replacement. One hundred nineteen patients (33.5%) experienced temporary hypothyroidism and spontaneously recovered to euthyroid state. High preoperative thyroid-stimulating hormone (TSH) was the most important factor predicting postoperative hypothyroidism and failure of recover from hypothyroidism (odds ratio [OR], 2.82 and 1.77; 95% confidence interval [CI], 2.07 to 3.95 and 1.22 to 2.63; P , 0.001 and 0.002, respectively). Of the 215 patients eventually developing postoperative hypothyroidism, 70 (32.6%) developed hypothyroidism after the first postoperative year. Postoperative 1-year TSH levels were able to differentiate patients developing late hypothyroidism or euthyroidism (OR, 2.29; 95% CI, 1.68 to 3.26; P , 0.001).Conclusions: Preoperative and postoperative TSH levels might be predictive for patients who develop postlobectomy hypothyroidism and identify those requiring long-term surveillance for hypothyroidism. Additionally, mild postoperative hypothyroidism cases should be followed up without immediate levothyroxine replacement with the expectation of spontaneous recovery.

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“…Hypovitaminosis D and thyroid autoimmunity were also described in a Chinese female population, where decreased TPOAb levels were associated with higher vitamin D levels. Interestingly, the correlation was found only in premenopausal women, but not in postmenopausal women or in men [4]. This result suggests a likely involvement of estrogens in modulating AITD.…”

Section: (Oh)d Values Than Healthy Controls (P =mentioning

confidence: 80%

Vitamin D and thyroid autoimmune diseases: the known and the obscure

Bizzaro

Shoenfeld

2014

Immunol Res

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Vitamin D is a secosteroid hormone, obtained from the diet or synthesized in human skin from 7-dehydrocholesterol after UV irradiation exposure. Its importance in calcium homeostasis is well recognized, as well its role in decreasing the risk of rickets, fractures, osteopenia, osteomalacia, and osteoporosis. What is a new developing issue is the involvement of vitamin D deficiency (commonly defined as less than 30 ng/ml) in the boost of many other disorders and especially in autoimmune diseases [1]. In light of these new acquisitions, vitamin D deficiency may represent a global health problem that has been underestimated for many years.Among all the autoimmune diseases which show an association with vitamin D deficiency and disease progression, we will focus on autoimmune thyroid diseases (AITD). Indeed, vitamin D deficiency modulates both Hashimoto thyroiditis (HT) and Graves' disease (GD). In several studies, the association between vitamin D and AITD was assessed analyzing various serological parameters, such as serum 25(OH)D levels, serum calcium, phosphate, parathyroid hormone (PTH), and antithyroid antibody levels. HT patients had significantly lower 25(OH)D values than healthy controls (p = 0.001), and low levels of serum 25(OH)D were also correlated with disease duration, thyroid volume, and antibody levels [2]. The association between vitamin D deficiency and antithyroid antibodies was reported for the first time by Kivity et al. [3], who studied a cohort of 92 patients with thyroid disorders, collected in a Hungarian endocrinology clinic. Antithyroid peroxidase (TPOAb) and antithyroglobulin (TgAb) antibodies were significantly more common in patients with vitamin D deficiency than in those with normal vitamin D levels. Hypovitaminosis D and thyroid autoimmunity were also described in a Chinese female population, where decreased TPOAb levels were associated with higher vitamin D levels. Interestingly, the correlation was found only in premenopausal women, but not in postmenopausal women or in men [4]. This result suggests a likely involvement of estrogens in modulating AITD. Moreover, the relationship between serum vitamin D status and thyroid-stimulating hormone (TSH) levels was investigated. Vitamin D levels were found associated with low circulating TSH levels in middle-aged and elderly males, independently of T3 and T4 levels. Interestingly, serum TSH levels in women were higher than those of same-aged men, indicating that TSH secretion may be regulated by sex hormones [5].Vitamin D status was also evaluated in female GD patients, showing significant lower levels compared with controls and demonstrating an association between serum 25(OH)D levels and serum calcium and intact parathyroid hormone levels. Recently, Yasuda and coworkers found an

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Low Levels of Serum Vitamin D3 Are Associated with Autoimmune Thyroid Disease in Pre-Menopausal Women

Cited by 81 publications

References 34 publications

Low vitamin D status is associated with hypothyroid Hashimoto’s thyroiditis

Low vitamin D status is associated with hypothyroid Hashimoto’s thyroiditis

Clinical Features of Early and Late Postoperative Hypothyroidism After Lobectomy

Vitamin D and thyroid autoimmune diseases: the known and the obscure

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