The Comparative Efficacy of Plant Sterols and Stanols on Serum Lipids: A Systematic Review and Meta-Analysis

Talati, Ripple; Sobieraj, Diana M; Makanji, Sagar S; Phung, Olivia J; Coleman, Craig I.

doi:10.1016/j.jada.2010.02.011

Cited by 84 publications

(54 citation statements)

References 31 publications

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“…So PS showed a long-lasting cholesterol lowering effect on its metabolism. Phytostanols vs. phytosterols: No significant difference in the serum lipids reducing properties of both sterols and stanols was found when comparable studies were conducted (Jones et al, 2000;Normen et al, 2000;Noakes et al, 2002), The effects of sterols and stanols esters are also relatively equivalent (Law, 2000, Talati et al, 2010. No-observed-adverse-effect (Cantrill and Kawamura, 2008 (modified); Lavova et al, 2013, (modified).…”

Section: Inhibition Of Cholesterol Cbsorption In Intestinementioning

confidence: 99%

Plant sterols for human health- A review

Jain

Bathla

2015

JANS

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Abstract:The aim of the article was to review phytosterols as functional food and its significance in lowering cholesterol as well as its specific effect on human health. Phytosterols has been known for its cholesterol lowering action long time back but the uprising of phytosterols in form of functional foods gained the interest once again. Fatty food matrix provides optimal solubility but fortification of phytosterols with other food matrices like low fat fermented milk, bread, juice are showing positive results. A dose of 2 g/day of either steryl or stanyl esters has been prescribed for an optimum effect which has been confirmed by FDA and EC. A number of studies have documented the safety and the efficiency of phytosterols. But there is still a big question mark on the use of it because of their adverse effect on body in form of Phytosterol oxidation products (POPs). It needs further investigation to elucidate effect of POPs within body.

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Section: Inhibition Of Cholesterol Cbsorption In Intestinementioning

confidence: 99%

Plant sterols for human health- A review

Jain

Bathla

2015

JANS

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“…Results from meta-analyses comparing the LDL-C lowering efficacy of plant stanols and sterols are conflicting (9,114,115). In an early metaanalysis, the pooled LDL-C reduction for plant stanols (10.1%; mean dose, 2.5 g/day) was not significantly different from that for plant sterols (9.7%; mean dose, 2.3 g/day) (9).…”

Section: Factors Affecting the Cholesterol-lowering Activity Of Plantmentioning

confidence: 99%

Lipid-lowering Activity of Natural and Semi-Synthetic Sterols and Stanols

2015

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-Consumption of plant sterols/ stanols has long been demonstrated to reduce plasma cholesterol levels. The objective of this review is to demonstrate the lipid-lowering activity and antiatherogenic effects of natural and semi-synthetic plant sterols/ stanols based on evidence from cell-culture studies, animal studies and clinical trials. Additionally, this review highlights certain molecular mechanisms by which plant sterols/ stanols lower plasma cholesterol levels with a special emphasis on factors that affect the cholesterol-lowering activity of plant sterols/stanols. The crystalline nature and the poor oil solubility of these natural products could be important factors that limit their cholesterol-lowering efficiency. Several attempts have been made to improve the cholesterol-lowering activity by enhancing the bioavailability of crystalline sterols and stanols. Approaches involved reduction of the crystal size and/or esterification with fatty acids from vegetable or fish oils. However, the most promising approach in this context is the chemical modification of plant sterols /stanols into water soluble disodium ascorbyl phytostanyl phosphates analogue by esterification with ascorbic acid. This novel semi-synthetic stanol derivative has improved efficacy over natural plant sterols/ stanols and can provide additional benefits by combining the cholesterol-lowering properties of plant stanols with the antioxidant potential of ascorbic acid.

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“…Plant sterols for adults with hypercholesterolemia treated with or without medication (statins) Plant sterols (also called phytosterols), are organic compounds from the plant kingdom which have a structure and cell function equivalent to that of cholesterol in vertebrates [13][14][15] . This similarity is of paramount importance when it comes to justifying their role in the control of cholesterol in humans as this means that both dietary and bile cholesterol compete with the plant sterols in the intestine to be absorbed.…”

Section: Citamentioning

confidence: 99%

Plant sterols for adults with hypercholesterolemia treated with or without medication (statins)

Bernácer

Roig²,

Lozano³

2015

Rev Esp Nutr Hum Diet

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Hypercholesterolemia is the most common coronary risk factor among the Spanish population; 37.4% of the Spanish adult population have cholesterol levels between 190 and 240 mg/dl. Foods enriched with plant sterols (PS) can effectively reduce plasma cholesterol in patients with high levels. However, its effectiveness and safety in adults with moderate hypercholesterolemia who are on medication (statins) or not has been less studied. The aim of this review is to establish the possible role of plant sterols in the control of hypercholesterolemia, as well as how safe they are for people with moderate hypercholesterolemia treated with statins. The main studies were looked at, regardless of design, language or publication date which studied the connection between "plant sterols" and "hypercholesterolemia", using Pubmed/Medline, SCOPUS and Google Scholar databases. The studies brought together in this review show that an intake of between 2 and 3g/day of plant sterols effectively reduces plasma cholesterol levels in patients with hypercholesterolemia. Both clinical studies and available meta-analyses do not indicate any problems related to the drug-nutrient interaction associated with the use of plant sterol-enriched foods. In patients with moderate hypercholesterolemia where the use of statins is not justified a healthy diet, exercise and foods high in PS can provide the best therapeutic approach. La hipercolesterolemia es el factor de riesgo cardiovascular más frecuente en la población española. El 37,4% de la población adulta española presenta niveles de colesterol de entre 190 y 240 mg/dl. Los alimentos enriquecidos con esteroles vegetales (EV) pueden disminuir de forma efectiva el colesterol plasmático en pacientes con niveles elevados, sin embargo su efecto y seguridad en adultos con hipercolesterolemia moderada, tratados o no con fármacos (estatinas) ha sido menos estudiada. El objetivo de la presente revisión es establecer el posible papel de los esteroles vegetales en el control de la hipercolesterolemia, así como su seguridad en personas con hipercolesterolemia moderada tratada con estatinas. Se revisaron los principales estudios, sin limitación de diseño, lengua o fecha de publicación que relacionara "esteroles vegetales" e "hipercolesterolemia", explotando las bases de datos Pubmed/Medline, SCOPUS y Google Scholar. Los estudios recuperados en la presente revisión muestran que el aporte de entre 2 y 3g/día de esteroles vegetales disminuyen de forma efectiva los niveles de colesterol plasmático en pacientes con hipercolesterolemia. Tanto los estudios clínicos como los metaanálisis disponibles no muestran problemas relacionados con la interacción fármaco-nutriente asociada al uso de alimentos enriquecidos con EV. En pacientes con hipercolesterolemia moderada en que no esté justificado el uso de estatinas, una alimentación saludable, actividad física y alimentos con EV, puede constituir el mejor acercamiento terapéutico. PALABRAS CLAVE

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The Comparative Efficacy of Plant Sterols and Stanols on Serum Lipids: A Systematic Review and Meta-Analysis

Cited by 84 publications

References 31 publications

Plant sterols for human health- A review

Plant sterols for human health- A review

Lipid-lowering Activity of Natural and Semi-Synthetic Sterols and Stanols

Plant sterols for adults with hypercholesterolemia treated with or without medication (statins)

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