The comparative developmental neurotoxicity of lead in humans and animals

Davis, J. Michael; Otto, David A.; Weil, David E.; Grant, Lester D.

doi:10.1016/0892-0362(90)90093-r

Cited by 152 publications

(50 citation statements)

References 123 publications

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“…In humans, this applies to children exposed either in utero to low doses of ethanol (24,25) or prenatally and postnatally to low doses of lead (26). In both instances, human and animal data have been shown to be in good agreement with each other (27,28).…”

Section: Introductionsupporting

confidence: 58%

Economical test methods for developmental neurobehavioral toxicity.

Bignami

1996

Environ Health Perspect

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Section: Introductionsupporting

confidence: 58%

Economical test methods for developmental neurobehavioral toxicity.

Bignami

1996

Environ Health Perspect

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“…Pb exposure has been associated with a broad spectrum of neurobehavioral effects [see review (32)] including the performance of East German children on tests similar to those used in the current project (35). We have not obtained measures of Pb exposure in Czech children evaluated thus far because of a limitation to noninvasive biological sampling methods such as urine and hair.…”

Section: Neurobehavioral Studiesmentioning

confidence: 99%

Teplice Program: The Impact of Air Pollution on Human Health

Srám¹,

Beneš²,

Binková³

et al. 1996

Environmental Health Perspectives

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Reproductive studies were conducted in both males and females. A study of the effects of exposure on pregnancy and birth found an excess prevalence of low birth weight and premature births in Teplice; these adverse effects were more common in infants conceived in the winter and whose mothers were smokers. Based on questionnaires and medical examination, the reproductive development of young men was not different between districts and seasons, however, measures of semen quality suggest that exposure to high levels of air pollution are associated with transient decrements in semen quality. Environ Health Perspect 1 04(Suppl 4): 699-714 (1996)

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“…Adults are more resistant to the effects of lead on the CNS, but some studies have reported cognitive impairment and changes in mood and affect following lead exposure in adult animals (2,3).…”

mentioning

confidence: 99%

Antidepressant-like effect of lead in adult mice

Mantovani

Matteussi

Rodrigues

1999

Braz J Med Biol Res

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It has been reported that lead can cause behavioral impairment by inhibiting the N-methyl-D-aspartate (NMDA) receptor complex. MK-801, a noncompetitive NMDA receptor antagonist, exhibits an antidepressant-like action in the forced swimming test. The purpose of the present study was to determine whether subacute lead exposure in adult male Swiss mice weighing 30-35 g causes an antidepressant-like action in a forced swimming test. Mice were injected intraperitoneally (ip) with 10 mg/kg lead acetate or saline daily for 7 consecutive days. Twenty-four hours after the last treatment, the saline and lead-treated mice received an injection of MK-801 (0.01 mg/kg, ip) or saline and were tested in forced swimming and in open-field tests. Immobility time was similarly reduced in the saline-MK-801, Pb-saline and Pb-MK-801 groups compared to the saline-saline group (mean ± SEM; 197.3 ± 18.5, 193.5 ± 15.8, 191.3 ± 12.3 and 264.0 ± 14.4 s, respectively; N = 9). These data indicate that lead may exert its effect on the forced swimming test by directly or indirectly inhibiting the NMDA receptor complex. Lead treatment caused no deficit in memory of habituation and did not affect locomotor activity in an open-field (N = 14). However, mice that received MK-801 after lead exhibited a deficit in habituation (22% reduction in rearing responses between session 3 and 1; N = 14) as compared to control (41% reduction in rearing responses; N = 15), further suggesting that lead may have affected the NMDA receptor activity. Forced-swim immobility in a basin in two daily consecutive sessions was also significantly decreased by lead exposure (mean ± SEM; day 1 = 10.6 ± 3.2, day 2 = 19.6 ± 3.6; N = 16) as compared to control (day 1 = 18.4 ± 3.8, day 2 = 34.0 ± 3.7; N = 17), whereas the number of crossings was not affected by lead treatment, further indicating a specific antidepressant-like action of lead.

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The comparative developmental neurotoxicity of lead in humans and animals

Cited by 152 publications

References 123 publications

Economical test methods for developmental neurobehavioral toxicity.

Economical test methods for developmental neurobehavioral toxicity.

Teplice Program: The Impact of Air Pollution on Human Health

Antidepressant-like effect of lead in adult mice

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