The common −55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population

Association of UCP2 and UCP3 polymorphisms with heart rate variability in Japanese men

“…ANOVA, analysis of variance; DBP, diastolic blood pressure; DM, diabetes mellitus; HT, hypertension; MBP, mean blood pressure; SBP, systolic blood pressure; SEM, standard error of mean. had a lower BMI than the C/C carriers, consistent with previous reports in Japanese and Caucasian individuals [41,59,60]. UCP3 plays a role in uncoupling oxidative phosphorylation in the skeletal muscle, heart, and adipose tissues and is thought to mediate the increase in energy expenditure [1,2].…”

“…All participants were in good health with almost ideal BMI and BP. Frequencies of the UCP2 45 bp I allele and the UCP3 À55T allele were 20.7 and 31.0%, respectively, similar to that reported previously in the Japanese population [41,42]. There were no significant deviations from the Hardy-Weinberg equilibrium for UCP2 45 bp insertion/deletion (…”

UCP2 I/D Modulated Change in BMI During a Lifestyle Modification Intervention Study in Japanese Subjects

“…In one, the relation with obesity only concerned premenopausal women (Matsushita et al, 2003), but not postmenopausal women, while in the other, the difference was found only between AG heterozygous and AA wild type and not between GG mutant homozygous and AA wild type (Nakano et al, 2006). Regarding the association between UCP3 -55C/T and BMI, the present study's findings are in accord with the previous studies conducted on Japanese (Hamada et al, 2008;Matsunaga et al, 2009). It has also been reported that, in addition to the association with UCP3 -55C/ T, there were associations of haplotypes (H5 and H6) of this polymorphism with UCP2 A55V and UCP3 rs2075577 (Kosuge et al, 2008).…”

“…Several studies have reported, though discrepantly, the association of obesity with UCP single-nucleotide polymorphisms (SNPs), including UCP1 -3826A/G (rs1800592) (Nakano et al, 2006;Jia et al, 2010), UCP2 -55 A/V (rs660339), a 45bp insertion-deletion polymorphism in the UCP2 gene (UCP2 I/D) (rs1800795), and UCP3 -55C/T (rs1800849) (Shiinoki et al, 1999;Hamada et al, 2008;Kosuge et al, 2008;Jia et al, 2009;Matsunaga et al, 2009). However, studies on the association between these SNPs and intervention-induced weight loss are few and, except for UCP1 -3826A/G (Nagai et al, 2011), none of these studies was conducted on Japanese subjects.…”

The value of HDL genetics

“…Reduced function or expression decreases energy expenditure and increases fat storage. Several recent studies identified significant associations between SNPs in genes encoding UCPs and HDLc levels [92][93][94].…”