UCP2 I/D Modulated Change in BMI During a Lifestyle Modification Intervention Study in Japanese Subjects

Abstract

Aim: Polymorphisms in uncoupling protein (UCP) genes have been strongly associated with energy expenditure and obesity. This study aimed at investigating the effects of UCP gene polymorphisms (UCP1 -3826A/G, UCP2A/V, UCP2 I/D, and UCP3 -55C/T) on change in body mass index (BMI) during a lifestyle modification program in Japanese subjects. Results: Intervention induced a significant decrease in energy intake ( -8.6% -17.0%) and a significant increase in energy expenditure (7.7% -7.4%). As a result, participants experienced a significant decrease in their BMI of -1.8% -2.7%. In a multivariate regression analysis, only UCP2 D/I among the selected UCP gene polymorphisms was associated with a change in BMI independent of the effects of gender, age, baseline BMI, changes in energy intake, and expenditure. Further regression analysis revealed that, in contrast to the DD genotype group, the DI + II genotype group showed no significant association between weight loss and change in energy expenditure suggesting this polymorphism altered the effects of this parameter on change in BMI. Conclusion: The study found UCP2 D/I to be associated with change in BMI by altering the effect of change in energy expenditure on change in BMI.

A Novel Mutation in the Promoter Region of Avian Uncoupling Protein3 Associated with Feed Efficiency and Body Composition Traits in Broiler Chicken.

“…Moreover, in the human field, some supportive investigations have indicated common mutations on promoter sites of UCP3 are associated with childhood obesity, energy expenditure, body weight alteration, and BMI (Mutombo et al, 2013;Brondani et al, 2014). Almost every research conducted on UCP3 recommended some promotion in feed efficiency and growth performance traits in chicken associated with UCP3 polymorphism in chicken (Nguyen et al, 2015;Moazeni et al, 2016;Jin et al, 2018), in Japanese quail (Murata et al, 2013), in New Zealand Romney lambs (An et al, 2018), and in Angus' steers (Kolath et al, 2006).…”

“…Additionally, the vast investigation indicated that this protein may play a major role in body energy expenditure, particularly in skeletal muscle (Bailey et al, 1998;Boss et al, 1998;Raimbault et al, 2001;Abe et al, 2006;Liu et al, 2007). In addition, consecutive pieces of literature were implemented to characterize the gene structure and detect variants in the UCP3, paid particular attention to alteration in energy expenditure, growth, obesity, and body mass index in Human (Mutombo et al, 2013;Brondani et al, 2014;An et al, 2018). Also, UCP3 variation analysis in animal genetic fields, collectively, elucidated significant differentiation on feed efficiency and performance traits in farm animals (Choi et al, 2006;Kolath et al, 2006;Liu et al, 2007;Murata et al, 2013;Moazeni et al, 2016;Jin et al, 2018).…”

Association of 45-bp Ins/del Polymorphism of Uncoupling Protein 2 (UCP2) and Susceptibility to Nonalcoholic Fatty Liver and Type 2 Diabetes Mellitus in North-west of Iran

“…A large number of studies in different populations have veri ed that carriers of the I-allele of UCP-2 gene had a signi cantly higher BMI and promoted possibility of the obesity [27,29]. Besides, it was found that individuals with I/D genotype had an increased rate in basal metabolic, high energy expenditure and lower BMI [30]. Another study revealed that patients with D/D genotype had a remarkable enhancement in total and truncal fat mass and body weight [31].…”

Association of 45-bp ins/del polymorphism of uncoupling protein 2 (UCP2) and susceptibility to nonalcoholic fatty liver and type 2 diabetes mellitus in North-west of Iran

“…Several studies in different populations have veri ed that carriers of the I-allele of the UCP-2 gene had a signi cantly higher BMI and the possibility of obesity [27,29]. Besides, it was found that individuals with I/D genotype had an increased rate of basal metabolism, high energy expenditure, and lower BMI [30]. Another study revealed that patients with D/D genotype had a remarkable enhancement in total and truncal fat mass and body weight [31].…”