The combined use of cytological imprint and frozen section in the intraoperative diagnosis of ovarian tumors

Souka, S.; Kamel, M. M.; Rocca, M.; El-Assi, M.; Hebeishy, N.; Sheir, Soheir

doi:10.1016/0020-7292(90)90180-s

Cited by 19 publications

(16 citation statements)

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“…Following this, several studies which were done in the past have discussed the use of imprint and touch preparations, especially as a tool for making the intraoperative diagnoses [4][5][6]. Few studies have documented ovarian cytological features in the imprint smears which were obtained during intraoperative procedures [7][8][9][10][11][12][13]. In this study, the routine use of cytological imprint smears allowed us to document these features and to underscore the advantages and the limitations of the technique.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Utility of Intraoperative Cytology in the Management of Ovarian Tumours

Vijayakumar¹

2013

JCDR

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Background: The present study was done to evaluate the status of intraoperative cytology as a diagnostic and supportive investigation for ovarian tumours. Materials and Methods:The present study was conducted in the Department of Pathology, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India during a time span of 13 months (June 2011 to June 2012). A prospective investigation was performed on 50 cases of suspected ovarian neoplasms. Imprint smears were made intraoperatively from fresh samples from various representative areas, and they were immediately fixed in 95% ethyl alcohol and stained with the haematoxylin and eosin stain. The results were compared with the final histopathological diagnoses in each case.Results: There were 20 benign lesions, 4 borderline epithelial neoplasms and 26 malignant tumours according to the final histopathological diagnosis. The overall diagnostic accuracy of imprint cytology has been satisfactory, with those of 90% of the cases correlating with the final diagnoses. Characteristic cytological patterns were noted in various surface epithelial, sex cord stromal and germ cell tumours. Conclusion:Imprint cytology can be used as an adjunct to histopathology for a rapid and an early diagnosis in the operation theatre, particularly in developing countries like ours, where the facility of frozen sections is often not available, since a rapid preliminary diagnosis may help in the surgical management planning.

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Section: Discussionmentioning

confidence: 99%

The Diagnostic Utility of Intraoperative Cytology in the Management of Ovarian Tumours

Vijayakumar¹

2013

JCDR

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“…Although relatively few studies have specifically examined cytological assessment of ovarian masses, these have shown promising results. [21][22][23][24] Indeed, in some centers, cytological preparations have been used as the initial diagnostic modality with frozen section restricted to problem cases. 24 The current study illustrated the advantages of intraoperative cytology in the assessment of ovarian masses.…”

Section: Discussionmentioning

confidence: 99%

Value of cytology in the intraoperative assessment of ovarian tumors

Stewart

Brennan

Koay

et al. 2010

Cancer Cytopathology

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BACKGROUND:Intraoperative pathological assessment is frequently requested in patients with suspected ovarian neoplasia so that optimal surgical management can be performed. In this study the accuracy of intraoperative cytology has been assessed and the results compared with frozen section diagnosis.METHODS:The study comprised 402 ovarian tumors that were submitted for intraoperative assessment in which both cytology preparations, usually scrape smears, and conventional frozen sections were examined. Each technique was evaluated independently, although the diagnosis transmitted to the surgeon was based upon the combination of the clinical, macroscopic, histological, and cytological information. The results were compared with the final pathological diagnosis in each case and cases with discordant diagnoses were reviewed.RESULTS:There were 226 benign lesions, 35 borderline epithelial neoplasms, and 141 malignant tumors according to the final pathological diagnosis. All benign lesions were accurately categorized using both frozen section and cytology. Thirty (86%) of the borderline tumors and 137 (97%) of the malignant tumors were accurately identified on frozen section, whereas the corresponding results for cytology were 23 (66%) and 131 (93%), respectively. There were no false‐positive diagnoses with either technique and the overall accuracy was 97.8%. Cytological evaluation provided better morphologic detail, permitted wider tumor sampling, and directed appropriate ancillary investigations in some cases.CONCLUSIONS:Overall, frozen section was more accurate than smear preparations in this series. However, cytology has a complementary role in the intraoperative assessment of ovarian neoplasia and provides a more specific diagnosis in some cases. Cancer (Cancer Cytopathol) 2010. © 2010 American Cancer Society.

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“…Preoperative and rapid intra-operative consultation is often called for. [5][6][7][8] In gynecologic surgeries frozen section is not often called for. However there is an increase in the preoperative FNA diagnosis being sought.…”

Section: Introductionmentioning

confidence: 99%

“…However there is an increase in the preoperative FNA diagnosis being sought. 5 Knowing the cyto-morphology of ovarian lesions will help in diagnosing lesions on FNA. Imprint cytology, as also scrape cytology offers the advantage of viewing the gross, giving serial cuts, taking multiple, representative samples and most importantly, being inexpensive and logistically un-demanding.…”

Section: Introductionmentioning

confidence: 99%

Imprint cytology in the diagnosis of ovarian lesions

Sushma

Panicker

2015

Int J Res Med Sci

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INTRODUCTIONHistopathology is the gold standard in diagnosis of resected specimens. Rapid intra-operative opinion is required to stage the disease and to modify the surgical procedure.[1] Many options are available. [2][3][4] Frozen section is most frequently resorted to. A major bulk of histopathology specimens is comprised of ovarian lesions. Preoperative and rapid intra-operative consultation is often called for. [5][6][7][8] In gynecologic surgeries frozen section is not often called for. However there is an increase in the preoperative FNA diagnosis being sought.5 Knowing the cyto-morphology of ovarian lesions will help in diagnosing lesions on FNA. Imprint cytology, as also scrape cytology offers the advantage of viewing the gross, giving serial cuts, taking multiple, representative samples and most importantly, being inexpensive and logistically un-demanding. This study was undertaken with the following objectives: 1. To study the imprint cytology of ovarian lesions comparing with their histopathology. 2. To evaluate the statistical implications of imprint cytology in diagnosing ovarian lesions. METHODSA total of 200 resections of ovarian neoplasms performed in our Gynecology Department over a period of 2 years were included in the study. The lesions were bisected when fresh, serial cuts made, when necessary. The ABSTRACT Background: Ovarian neoplasms constitute a major bulk of surgical pathology specimens. Histopathology is the gold standard in diagnosis. Of the many options available for a rapid intra-operative diagnosis imprint cytology has many advantages. This study therefore aimed to study the imprint cytology of ovarian lesions and compare with the histopathology findings and analyze the statistical effectiveness of this study as a rapid intra-operative diagnostic tool. Methods: 200 lesions resected over a 2 year period were included in the study. Lesions were bisected when fresh. Clean glass slides touched firmly over the representative areas. Immediate fixation was in 95% ethanol and staining was by Rapid Papanicolaou method. Of the 200 cases studied, 5 were lost to follow up, and hence were excluded from the study. Results:The 195 cases were classified broadly according to WHO system into 4 groups and the lesions were statistically analyzed. 122 surface epithelial tumors showed 97.5%sensitivity and 94.5%specificity in diagnosis with an overall accuracy of 96.4%. 8 sex cord stromal tumors had 98.5% diagnostic accuracy with a specificity of 99.5%. There was 100 % sensitivity and specificity in diagnosing the 25 germ cell tumors. The tumor like lesions showed a diagnostic accuracy of 97% with a specificity of 100%. Conclusions: Imprint cytology is an inexpensive and a fairly sensitive tool for rapid intra-operative diagnosis.

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The combined use of cytological imprint and frozen section in the intraoperative diagnosis of ovarian tumors

Cited by 19 publications

References 1 publication

The Diagnostic Utility of Intraoperative Cytology in the Management of Ovarian Tumours

The Diagnostic Utility of Intraoperative Cytology in the Management of Ovarian Tumours

Value of cytology in the intraoperative assessment of ovarian tumors

Imprint cytology in the diagnosis of ovarian lesions

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