The Combined Effect of Amniotic Membrane and Moringa oleifera Leaves Derived Gel for Wound and Burn Healing in Rat Model

Islam, M. R.; Hossain, Liakat; Diba, Farzana; Hasan, Md. Zahid; Juliana, Farha Matin; Asaduzzaman, SM

doi:10.1007/s40883-018-0060-4

Cited by 5 publications

(9 citation statements)

References 20 publications

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“…Our search from the six databases produced a total of 80 related articles. After removing duplicates, 59 articles were screened and 18 articles were included [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ], as summarized in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Majority of the studies indicate that M. oleifera was applied topically and formulated as gel (six studies [ 30 , 39 , 44 , 47 ] followed by using the extract in the form of paste, patch, or film dressing (five studies [ 30 , 33 , 36 , 40 ] and the remaining an ointment (three studies [ 34 , 41 , 42 ]. Two studies reported oral administration of M. oleifera aqueous extracts (two studies [ 38 , 43 ] while another two reported dual administration of both topical (ointment and aqueous extract) and oral (aqueous extracts) (two studies [ 32 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…None of the 18 studies reported qualitative analysis to determine the phytochemicals associated with M. oleifera or reported quantitative analysis to determine the composition of the associated phytochemicals in M. oleifera. Only two studies reported using a standardized formulation M. oleifera but details are incomplete [ 33 , 39 ]. Detailed information on the qualitative and quantitative phytochemical analysis, as well as standardization formula of the herbal interventions of all included studies, are presented in the Supplementary Material (Table S3) .…”

Section: Resultsmentioning

confidence: 99%

“…Skin irritation studies of aqueous extracts of M. oleifera leaves hydrogel (500 mg/animal) administered topically on excision wound of Wistar rats (200–250 g) twice a day for 7 days showed no skin irritation signs during the whole period of study [ 47 ]. A skin irritation test carried out using a mixture of aqueous extracts of M. oleifera leaves (MO) and human amniotic membrane (AM)-formulated gel (2% MO + AM) administered topically on wounds on female Wistar rats for 7 days did not show any skin oedema, itchiness, or erythema, suggesting tolerable dermal application [ 39 ]. A skin patch/scratch and skin sensitization test carried out using an ethanol extract of M. oleifera twigs (5 mg/mL, 7.5 mg/mL and 10 mg/mL) on a wound area of healthy guinea pigs also showed no erythema or oedema [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Scoping Review: Evaluation of Moringa oleifera (Lam.) for Potential Wound Healing in In Vivo Studies

et al. 2022

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Wound healing is a natural process to restore damaged tissues due to loss of tissue integrity. Moringa oleifera (locally known as merunggai in Malaysia) has been traditionally used in various ailments, including for wound management. To evaluate the wound healing properties in M. oleifera, publications were searched and selected following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement with predetermined inclusion criteria. The databases searched for primary studies include PubMed, Google Scholar, Science Direct, LILACS, ClinicalTrials.gov, and CENTRAL. In total, 18 in vivo studies were included, which involved the leaves, while the remaining 5 studies involved other plant parts tested on excision, incision, dead space, abrasion, and burn-induced wound models. All studies reported significant wound healing abilities. Most studies used different topical formulations of aqueous leaves extract. The accumulation of collagen content and underlying wound healing mechanism through antimicrobial, antioxidant, and anti-inflammatory activities may be contributed by its bioactive phytochemical content, which has the potential to accelerate the wound contraction, increase the rate of epithelialization, and protect tissues against oxidative damage. In conclusion, M. oleifera showed wound healing potential but further studies are warranted to determine the main bioactive phytocompounds and safety.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Scoping Review: Evaluation of Moringa oleifera (Lam.) for Potential Wound Healing in In Vivo Studies

et al. 2022

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“…Normal wound healing requires coordinated communication between cells, growth factors, and ECM proteins. Activated stem cells are critical in this process as they enable a coordinated repair response [ 78 , 79 ].…”

Section: Applications Of Amniotic Membrane On the Skin Regenerationmentioning

confidence: 99%

Application of Amniotic Membrane in Skin Regeneration

et al. 2023

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Amniotic membrane (AM) is an avascular structure composed of three different layers, which contain collagen, extracellular matrix, and biologically active cells (stem cells). Collagen, a naturally occurring matrix polymer, provides the structural matrix/strength of the amniotic membrane. Tissue remodeling is regulated by growth factors, cytokines, chemokines, and other regulatory molecules produced by endogenous cells within AM. Therefore, AM is considered an attractive skin-regenerating agent. This review discusses the application of AM in skin regeneration, including its preparation for application to the skin and its mechanisms of therapeutic healing in the skin. This review involved collecting research articles that have been published in several databases, including Google Scholar, PubMed, Science Direct, and Scopus. The search was conducted by using the keywords ‘amniotic membrane skin’, ‘amniotic membrane wound healing’, ‘amniotic membrane burn’, ‘amniotic membrane urethral defects’, ‘amniotic membrane junctional epidermolysis bullosa’, and ‘amniotic membrane calciphylaxis’. Ultimately, 87 articles are discussed in this review. Overall, AM has various activities that help in the regeneration and repair of damaged skin.

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Human Amniotic Membrane and Titanium Dioxide Nanoparticle Derived Gel for Burn Wound Healing in a Rat Model

Islam

Karmakar

Tusher-Al-Arafat

et al. 2022

Regen. Eng. Transl. Med.

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The Combined Effect of Amniotic Membrane and Moringa oleifera Leaves Derived Gel for Wound and Burn Healing in Rat Model

Cited by 5 publications

References 20 publications

Scoping Review: Evaluation of Moringa oleifera (Lam.) for Potential Wound Healing in In Vivo Studies

Scoping Review: Evaluation of Moringa oleifera (Lam.) for Potential Wound Healing in In Vivo Studies

Application of Amniotic Membrane in Skin Regeneration

Human Amniotic Membrane and Titanium Dioxide Nanoparticle Derived Gel for Burn Wound Healing in a Rat Model

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