The Combination of CA125 and NSE Is Useful for Predicting Liver Metastasis of Lung Cancer

Abstract

Purpose. Liver metastasis is the final stage of cancer progression and is associated with poor prognosis. Although numerous indicators have been identified as having prognostic value for lung cancer and liver metastasis, liver metastases are still not diagnosed by imaging in many patients. To provide a more accurate method for clinical prediction of liver metastasis, we analyzed multiple factors to identify potential predictive factors for liver metastasis of lung cancer. Methods. Patients first diagnosed with lung cancer between 2002 and 2016 ( n = 1746 ) were divided into two groups, with and without liver metastasis. Serum concentrations of calcium, carcinoembryonic antigen (CEA), cancer antigen-125 (CA125), cancer antigen-153 (CA153), carbohydrate antigen-199 (CA199), cytokeratin fraction 21-1 (CYFRA21-1), total prostate-specific antigen (TPSA), and neuron-specific enolase (NSE) were analyzed in both patient groups. Results. There was no significant difference in age or sex between the two groups. CA125 and NSE were significantly associated with liver metastasis. Compared with CA125, NSE was more specific, while it was less sensitive ( P < 0.001 ). Further analysis of NSE concentrations was conducted in patients with non-small-cell lung cancer and indicated that NSE concentration differed significantly between those with and without liver metastasis ( P = 0.023 ). We conducted analysis with NSE and CA125 combined, resulting in acceptable sensitivity (51.2%), specificity (72.6%), and area under the curve (0.64) values; sensitivity and area under the curve values were higher than those for individual factors, while specificity was higher than that for CA125. Conclusions. The combination of CA125 and NSE can assist prediction of liver metastasis of lung cancer, providing improved diagnostic accuracy.

Effect Evaluation of Bronchial Artery Embolization for Hemoptysis of Lung Cancer and Changes in Serum Tumor Markers and miR-34 Levels

“…Early CA125 is commonly used in clinical diagnosis of ovarian cancer, prognosis judgment, and prediction of disease recurrence with high sensitivity and positive rate, while CA125 is highly expressed in the serum of lung cancer patients [ 12 ]. The Neuron-specific enolase (NSE) is a highly expressed rate-limiting enzyme in lung cancer tissues, which is about 30 times the normal level, and the sensitivity of NSE to the diagnosis of lung cancer is over 70% [ 13 ]. The results of this study showed that the tumor markers in both groups were significantly reduced, and the inhibitory effect of BAE treatment was better.…”

A Clinical Diagnostic Value Analysis of Serum CA125, CA199, and HE4 in Women with Early Ovarian Cancer: Systematic Review and Meta-Analysis

“…Due to the lack of early symptoms of ovarian cancer and the lack of early screening and diagnosis, the survival rate of patients has been less than 30% [ 3 ]. However, if detected at early stage and given standard surgery and adjuvant therapy, the 5-year survival rate of ovarian cancer can be as high as 90% [ 4 ]. 80% of patients with ovarian epithelial carcinoma showed the elevated expression level of carbohydrate antigen 125 (CA125) in serum, and more than 90% of patients showed serum CA125 level correlated with disease severity.…”

Preliminary Study on the Predictive Value of Serum Tumor Markers for Liver Metastasis of Lung Cancer

“…The liver, which benefits from rich blood supply, is easily affected through blood circulation. Once liver metastasis occurs, the tumor gradually progresses to the final stage [9]. Early detection of liver metastasis in lung cancer is helpful for individualized treatment and prognosis assessment of patients as early as possible, while sensitive tumor markers can help identify disease progression.…”