The Combination Effects of Early Intratympanic Dexamethasone Injection for Patients with Sudden Sensorineural Hearing Loss

Abstract

Objective: Determine the efficacy of a steroid regimen for patients with idiopathic sudden sensorineural hearing loss (SSNHL) and evaluate the relationship between outcome and initial steroid dose.Method: A retrospective review of patients with SSNHL was conducted at our hospital from 2004 to 2008. The study group consisted of 272 patients in whom SSNHL was diagnosed. Patients received tapering courses of intravenous hydrocortisone (HC) with an initial dose of either 500 mg/d for 3 days or 300 mg/d. Results:The overall recovery rates after treatment were 68% in total group. The time interval from onset of SSNHL to start of treatment was important for the outcome of hearing improvement. There is significant difference between the under and over 50 years old groups in improvement of HL. A total of 47% (n = 128) were treated with high dose (500 mg/d) HC, and 53% (n = 144) were treated with low dose (300 mg/d) HC. There were no significant differences between the high dose and low dose groups in terms of hearing outcome.Conclusion: High dose steroid therapy had the same outcome as low dose steroid therapy against patients with SSNHL.Objective: The purpose of this study was to compare the dimensional measurements and surface topography of geometry reconstructed from high-resolution computerized tomography (HRCT) of temporal bone with the same natural ears.by guest on June 4, 2016 oto.sagepub.com Downloaded from

Association Between Vertigo and Hearing Prognosis in Patients with Sudden Sensorineural Hearing Loss: a Systematic Review and Meta-analysis

“…The etiology of most cases is unknown, and 71% of cases are categorized as idiopathic [1] . In addition, the underlying pathologic mechanisms are not fully understood, and currently proposed hypotheses include viral infections, microcirculatory disorders, and autoimmune diseases [2] . The ambiguous etiology has led to a failure to develop uniform standards for its treatment options.…”

Comparison of the Effect of Intratympanic Steroid Injection Medications in Patients with Idiopathic Sudden Sensorineural Hearing Loss

“…[5][6][7] 스테로이드의 고실 내 스테로이드 주입술은 정원창을 통하여 직접적인 경로로 도달하여 상대적으로 소량 의 약물로 외림프 내 농도를 높일 수 있으며, 전신 요법에 비 해 전신 스테로이드 독성을 줄일 수 있어서, 5,8,9) 고실 내 스테 로이드 주입술은 치료에 반응이 없는 환자 및 전신 요법 시행 이 어려운 환자에 유용하다. 5,8,10) 전신적인 고용량 스테로이드 와 병행하여 실시하는 경우 추가적인 이득에 대하여 이견이 있으나, 11,12) 전신 스테로이드 단독에 비해 유의하게 회복률이 높았다는 보고가 다수 존재한다. 3,5,[13][14][15][16] 또한, 고실 내 주입술 단독으로 경구 요법과 동등한 효과를 얻은 보고들도 있다.…”