The Clinical Implication of Blood Product Transfusion on Morbidity and Mortality of Ruptured Abdominal Aortic Aneurysm

Kordzadeh, Ali; Askari, Alan; Parsa, Ali Davod; Browne, Tom; Panayiotopoulos, Y.P.

doi:10.1177/1076029615624548

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…Patients who were scheduled to undergo the open repair of a ruptured AAA, however, received no significant benefit from the early administration of platelets with regard to postoperative complications and mortality [ 99 ]. Platelet transfusion was an independent marker of thrombotic complications in patients with ruptured AAA [ 100 ].…”

Section: Resultsmentioning

confidence: 99%

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Targeting Platelet Activation in Abdominal Aortic Aneurysm: Current Knowledge and Perspectives

2022

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Abdominal aortic aneurysm (AAA) is a potentially fatal vascular disease that involves complex multifactorial hemodynamic, thrombotic, inflammatory, and aortic wall remodeling processes. However, its mechanisms are incompletely understood. It has become increasingly clear that platelets are involved in pathological processes of vascular diseases beyond their role in hemostasis and thrombosis. Platelet activation with membrane receptors and secreted mediators promotes thrombus formation and the accumulation of inflammatory cells, which may play an important role in the development of AAA by destroying the structural integrity and stability of the vessel wall. Turbulent blood flow in aortic aneurysms promotes platelet activation and aggregation. Platelet count and heterogeneity are important predictive, diagnostic, and prognostic indicators of AAA. We summarize the relationship between platelet activation and AAA development and propose future research directions and possible clinical applications.

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Section: Resultsmentioning

confidence: 99%

“…Platelet transfusion was an independent marker of thrombotic complications in patients with ruptured AAA [100].…”

Section: Platelet Infusion and Perioperative Periodmentioning

confidence: 89%