Targeting Platelet Activation in Abdominal Aortic Aneurysm: Current Knowledge and Perspectives

Sun, Weiliang; Zheng, Jingang; Gao, Yanxiang

doi:10.3390/biom12020206

Cited by 16 publications

(18 citation statements)

References 105 publications

(117 reference statements)

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“…Lastly, from a purely speculative viewpoint, we could hypothesize that the increased incidence of refractory TIIEL in patients with CAD, as shown by the univariate analysis and the ANOVA test results ( Table 1 and Figure 1 ), could be related to an active thrombus remodeling after EVAR due to a more aggressive systemic atherosclerosis [ 27 ], involving plasmatic mediators [ 28 ]. Undoubtedly, this is only a research hypothesis that needs to be proved in further dedicated studies.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Fate of Refractory Type II Endoleak after EVAR: A Retrospective Experience of Two High-Volume Italian Centers

Sirignano

Mangialardi

Nespola

et al. 2022

JPM

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Introduction: The aim of the present study is to report the outcome of patients presenting an isolated type II endoleak (TIIEL) requiring reintervention and to identify clinical and anatomical characteristics potentially implicated in refractory TIIEL occurrence and fate. Materials and Methods: A multicenter retrospective study on TIIEL requiring reintervention was conducted between January 2003 and December 2020. Demographic and clinical characteristics, procedural technical aspects, reinterventions, and outcomes were recorded. TIIEL determining sac expansion greater than 10 mm underwent a further endovascular procedure aiming to exclude aneurismal sac. Redo endovascular procedures were performed via endoleak nidus direct embolization and/or aortic side branches occlusion. TIIELs responsible for persisting aneurysmal sac perfusion 6 months after redo endovascular procedures were classified as “refractory” and submitted to open conversion. Results: A total of 102 TIIEL requiring reintervention were included in the final analysis. Eighty-eight (86.27%) patients were male, the mean age was 77.32 ± 8.08 years, and in 72.55% of cases the American Society of Anaesthesiologists (ASA) class was ≥3. The mean aortic diameter was 64.7 ± 14.02 mm, half of treated patients had a patent inferior mesenteric artery (IMA), and 44.11% ≥ 3 couples of patent lumbar arteries (LA). In 49 cases (48.03%) standard endovascular aneurysm repair (EVAR) procedure was completed without adjunctive maneuvers. All enrolled patients were initially submitted to a further endovascular procedure once TIIEL requiring reintervention was diagnosed; 57 patients underwent LAs or IMA embolization (55.87%), 42 transarterial aneurismal sac embolization (41.17%), and three (2.96%) laparoscopic ostial ligations of the inferior mesenteric artery. During a mean follow-up of 15.22 ± 7.57 months (7–48), a redo endovascular approach was able to ensure complete sac exclusion in 52 cases, while 50 patients presented a still evident refractory TIIEL and therefore a surgical conversion or semiconversion was conducted. At the univariate analysis refractory TIIEL patients were significantly different from those who did not develop the complication in terms of preoperative clinical, morphological characteristics, and initial EVAR procedures: coronary artery disease occurrence (p = 0.005, OR: 3.18, CI95%: 1.3–7.2); preoperative abdominal aortic aneurysm (AAA) sac diameter (p = 0.0055); IMA patency (p = 0.016, OR: 2.64, CI95%: 1.18–5.90); three or more patent LAs; isolated standard EVAR without adjunctive procedures (p > 0.0001; OR: 9.48, CI95%: 3.84–23.4). Conclusions: Our experience seems to demonstrate that it is reasonable to try to preoperatively identify those patients who will develop a refractory TIIEL after EVAR and those with a TIIEL requiring reintervention for whom a simple endovascular redo will not be enough, needing surgical conversion.

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Section: Discussionmentioning

confidence: 99%

Incidence and Fate of Refractory Type II Endoleak after EVAR: A Retrospective Experience of Two High-Volume Italian Centers

Sirignano

Mangialardi

Nespola

et al. 2022

JPM

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“…Indeed, two novel CCT diseases showed a significant association to PTS, and four novel CCT diseases showed a significant association to Notoginseng. These included Aortic Aneurysm (a dilation Herb-paths in the aorta which can be caused/aggravated by platelet aggregation 40 ); which might benefit from the anti-platelet treatment provided by Notoginseng/PTS 12,27 .…”

Section: Discussionmentioning

confidence: 99%

Herb-paths, a network and statistical model to explore health-beneficial effects of herbs and herbal constituents

Voet¹,

Rijnberk³

et al. 2022

Preprint

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Predictions on bioactivities of herbs and herbal compounds could greatly aid drug development, but require integration of available information on herb and compound effects from various databases. We present Herb-paths, an integrated network connecting information on health-beneficial effects of herbs and herbal constituents. The statistical models included in Herb-paths allow for the calculation of the association strength of herbal (constituents) with health-beneficial effects, for both known and novel effects, and give insight into the major bioactive compounds and molecular mechanisms driving the effects. Herb-paths' predictions were tested and validated using a case-study of Panax notoginseng and its derived medicinal extract of Panaxatriol saponins (PTS), used in traditional Chinese medicine to treat stroke and other cardiovascular and cerebrovascular thromboembolic (CCT) disorders. Results showed that Herb-paths predicted known and novel associations between PTS/Notoginseng and CCT phenotypes and diseases, including stroke. Predicted novel associations, such as MoyaMoya disease, are promising putative leads for treatment with PTS/Notoginseng, to be tested in further studies.

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“…In recent years, many studies have tried establishing the role of activated platelets in the development and progression of AAA. Aside from their crucial role in thrombosis and hemostasis, a non-occlusive intraluminal thrombus (ILT) formation is known to contribute to the pro-inflammatory and prothrombotic backdrop of AAA (88)(89)(90). It was initially hypothesized that ILT could act as a protective mechanism to reduce mechanical stress induced on the vascular wall (91).…”

Section: Intraluminal Thrombus and Mechanosensing In Aaamentioning

confidence: 99%

Mechanosignals in abdominal aortic aneurysms

Lowis

Winaya

Kumari

et al. 2023

Front. Cardiovasc. Med.

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Cumulative evidence has shown that mechanical and frictional forces exert distinct effects in the multi-cellular aortic layers and play a significant role in the development of abdominal aortic aneurysms (AAA). These mechanical cues collectively trigger signaling cascades relying on mechanosensory cellular hubs that regulate vascular remodeling programs leading to the exaggerated degradation of the extracellular matrix (ECM), culminating in lethal aortic rupture. In this review, we provide an update and summarize the current understanding of the mechanotransduction networks in different cell types during AAA development. We focus on different mechanosensors and stressors that accumulate in the AAA sac and the mechanotransduction cascades that contribute to inflammation, oxidative stress, remodeling, and ECM degradation. We provide perspectives on manipulating this mechano-machinery as a new direction for future research in AAA.

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Targeting Platelet Activation in Abdominal Aortic Aneurysm: Current Knowledge and Perspectives

Cited by 16 publications

References 105 publications

Incidence and Fate of Refractory Type II Endoleak after EVAR: A Retrospective Experience of Two High-Volume Italian Centers

Incidence and Fate of Refractory Type II Endoleak after EVAR: A Retrospective Experience of Two High-Volume Italian Centers

Herb-paths, a network and statistical model to explore health-beneficial effects of herbs and herbal constituents

Mechanosignals in abdominal aortic aneurysms

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