The Citrus Flavanone Naringin Enhances Antioxidant Status in the Albino Rat Liver Treated with Doxorubicin

Ch, Ganesh; Jagetia, ra; Lalnuntluangi, Vanessa

doi:10.21767/2471-8084.100018

Cited by 17 publications

(28 citation statements)

References 56 publications

(74 reference statements)

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“…32,62,63,65 The naringin treatment reduced the catalase activity in the mouse liver which is in agreement with the earlier studies where a similar effect has been reported. 32,[63][64][65] Both the treatment of naringin before or after DOX administration was equally effective in raising the catalase activity in mouse liver in the present study. Likewise, Aegle mamrmelos extract attenuated the doxorubicin-induced alleviation in the catalase activity of mice heart.…”

Section: Discussionsupporting

confidence: 91%

“…The naringin has been reported to elevate the GST activity in mouse heart and liver of mouse and rat earlier. 32,63 This elevation in GST by naringin may play an important role in reduced DOX toxicity in the liver.…”

Section: Discussionmentioning

confidence: 99%

“…32,[61][62][63] Naringin treatment has been found to elevate the GSH concentration in the heart and liver of doxorubicin treated mice and rats. 32,[63][64][65] Similarly, extract of Agele marmalos has been reported to elevate myocardial glutathione in mice. 62 Glutamine an amino acid has been reported to protect against the DOX-induced depletion in GSH in rats.…”

Section: Discussionmentioning

confidence: 99%

“…DOX has been reported to decrease the activity of SOD earlier leading to oxidative stress. 32,62,63 Naringin treatment has been reported to inhibit the DOX induced reduction in the SOD activity in heart and liver of mice and rats. 32,[63][64][65] Similarly, naringin also suppressed the belomycin-induced decline in the SOD activity.…”

Section: Discussionmentioning

confidence: 99%

“…32,62,63 Naringin treatment has been reported to inhibit the DOX induced reduction in the SOD activity in heart and liver of mice and rats. 32,[63][64][65] Similarly, naringin also suppressed the belomycin-induced decline in the SOD activity. 43 Phytic acid and wheat germ oil have been found to arrest the doxorubicin-induced decline SOD activity in rat liver, kidney and spleen.…”

Section: Discussionmentioning

confidence: 99%

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Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Ch¹,

Jagetia²,

Lalrinengi³

2017

MOJAP

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Doxorubicin a photosensitive antibiotic is frequently used to treat various malignancies in clinics; however, doxorubicin is also taken up by the normal cells of the body leading to increased oxidative stress and subsequently DNA damage and dysfunction in the cells. The agents which can reduce the adverse effect of doxorubicin will of great value. The present study has attempted to study the effect of naringin a citrus flavonoid on the doxorubicininduced oxidative stress in mice liver. The mice were administered with 0, 1, 5 or 10mg/ kg body weight of doxorubicin and treated with 10mg/kg body weight of naringin before or after doxorubicin treatment. The glutathione concentration and lipid peroxidation and activities of glutathione-s-transferase, catalase and super oxide dismutase were studied at 0.5, 1, 2 and 4h post-treatment in the mouse liver. The doxorubicin increased the lipid peroxidation in a dose dependent manner at all the post treatment times. Conversely, it attenuated the activities of glutathione-s-transferase, catalase and super oxide dismutase in dose dependent fashion and time dependent manner. A similar effect was observed for glutathione concentration. Treatment of mice with naringin before or after doxorubicin treatment elevated all the antioxidants and reduced the doxorubicin -induced lipid peroxidation. The effect of naringin pretreatment was more effective when compared to its post treatment. The naringin was very effective in reducing the oxidative stress induced by doxorubicin as indicated by the elevated levels of glutathione concentration, glutathiones-transferase, catalase and super oxide dismutase. The pretreatment of naringin was better than its post treatment.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Ch¹,

Jagetia²,

Lalrinengi³

2017

MOJAP

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Protective effects of naringin against drugs and chemical toxins induced hepatotoxicity: A review

Shirani

Yousefsani

Shirani

et al. 2020

Phytotherapy Research

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The liver is a vital metabolic organ for drug and xenobiotic metabolism which is influenced by chemical and natural toxins. Liver injury is associated with systemic oxidative stress, which leads to cellular necrosis, fibrosis, tissue lipid peroxidation, and depletion in glutathione levels. Considering the lack of reliable hepato‐protective drugs in modern medicine, plant‐derived phytoconstituents seem to be a noteworthy option. Naringin is an abundant flavonoid found in citrus fruits with various pharmacological benefits such as antioxidant, anti‐inflammatory, and antiapoptotic, activities. In this review, we summarize available data from recent studies about the hepatoprotective effects of naringin against chemical toxicants and discuss the possible mechanisms of actions.

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Formulation of Naringin Encapsulation in Zein/Caseinate Biopolymers and its Anti-adipogenic Activity in 3T3-L1 Pre-adipocytes

et al. 2020

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The Citrus Flavanone Naringin Enhances Antioxidant Status in the Albino Rat Liver Treated with Doxorubicin

Cited by 17 publications

References 56 publications

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Protective effects of naringin against drugs and chemical toxins induced hepatotoxicity: A review

Formulation of Naringin Encapsulation in Zein/Caseinate Biopolymers and its Anti-adipogenic Activity in 3T3-L1 Pre-adipocytes

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