Protective effects of naringin against drugs and chemical toxins induced hepatotoxicity: A review

Abstract

The liver is a vital metabolic organ for drug and xenobiotic metabolism which is influenced by chemical and natural toxins. Liver injury is associated with systemic oxidative stress, which leads to cellular necrosis, fibrosis, tissue lipid peroxidation, and depletion in glutathione levels. Considering the lack of reliable hepato‐protective drugs in modern medicine, plant‐derived phytoconstituents seem to be a noteworthy option. Naringin is an abundant flavonoid found in citrus fruits with various pharmacological benefits such as antioxidant, anti‐inflammatory, and antiapoptotic, activities. In this review, we summarize available data from recent studies about the hepatoprotective effects of naringin against chemical toxicants and discuss the possible mechanisms of actions.

Antioxidant mediated protective effect of Bridelia tomentosa leaf extract against carbofuran induced oxidative hepatic toxicity

“…On the other hand, Naringin is a natural flavanone glycoside that possesses different biological and pharmacological properties [ 45 ] and showed potent hydroxyl radicals, superoxide, hydrogen peroxide, nitric oxide radical, and DPPH radical scavenging activity [ 46 ]. Shirani and his peers demonstrated the hepatoprotective effects of naringin against different chemical toxicants such as acetaminophen, doxorubicin, cyclophosphamide, cisplatin, and carbon tetrachloride [ 47 ]. In the same way, chronic naringin treatment mitigated oxidative damage, as supported by dropping of malondialdehyde level and refurbishment of superoxide dismutase, catalase and glutathione S-transferase levels against colchicine-induced oxidative damage [ 48 ].…”

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

“…To analyze the positives effects of flavanones in liver different approaches have been used. Some authors worked with hepatic chemical-induced damage being the most used the streptozotocin injection to mice or rats [ 199 , 201 ]. Other authors induced liver damage with diet [ 199 ] or worked with genetically obese models.…”

Effect of Naringin Treatment on Postmenopausal Osteoporosis in Ovariectomized Rats: A Meta-Analysis and Systematic Review

“…Studies have shown that naringin can promote the differentiation and proliferation of various types of cells [ 9 – 12 ] and improve the bone mass in an osteoporotic rat model [ 9 ]. Naringin also promotes osteoclast apoptosis through the mitochondrial-mediated apoptotic pathway, so as to inhibit bone loss in OVX rat models and exhibit antiosteoporotic pharmacological activity [ 13 , 14 ].…”