Formulation of Naringin Encapsulation in Zein/Caseinate Biopolymers and its Anti-adipogenic Activity in 3T3-L1 Pre-adipocytes

Nallamuthu, Ilaiyaraja; Ponnusamy, Vinithra; Smruthi, M. R.; Khanum, Farhath

doi:10.1007/s10876-020-01909-1

Cited by 15 publications

(11 citation statements)

References 43 publications

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“…Therefore, particle size and distribution, surface charge are key indicators for evaluating these characteristics ( Hu et al, 2016 ). For particles distribution uniformity, PDI is a very important parameter to be evaluated ( Nallamuthu, Ponnusamy, Smruthi, & Khanum, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

“…As we know, the isoelectric point of OVA falls in the range of 4.59–4.71, around which OVA could easily form particle by protein aggregation. In pH 3 condition, OVA play a great role in self-aggregation showing positive charge and have electrostatic interaction with negative CKGM ( Nallamuthu et al, 2021 ). We also found that the addition of naringin (5, 7, 12 mg/mL) hardly showed impact on the diameter and PDI of OVA/CKGM NPs, therefore naringin concentration was not taken into account in this assay.…”

Section: Resultsmentioning

confidence: 99%

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Fabrication, characterization of carboxymethyl konjac glucomannan/ovalbumin-naringin nanoparticles with improving in vitro bioaccessibility

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Fabrication, characterization of carboxymethyl konjac glucomannan/ovalbumin-naringin nanoparticles with improving in vitro bioaccessibility

et al. 2022

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“…found that zein could interact with (−)‐epigallocatechin gallate (EGCG) or quercetin in an ethanol–water solution (70%, v/v ) via covalent and non‐covalent bonding 7 . Moreover, zein was used to encapsulate NEN and NIN to improve their functional properties 17,18 . However, as far as is known, minimal studies are available regarding whether the digestive stability of citrus flavonoids can be enhanced by binding with zein.…”

Section: Introductionmentioning

confidence: 99%

“…7 Moreover, zein was used to encapsulate NEN and NIN to improve their functional properties. 17,18 However, as far as is known, minimal studies are available regarding whether the digestive stability of citrus flavonoids can be enhanced by binding with zein.…”

Section: Introductionmentioning

confidence: 99%

Zein enhanced the digestive stability of five citrus flavonoids via different binding interaction

Zhang

Tan

et al. 2022

J Sci Food Agric

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BACKGROUND: Zein is commonly used to construct food flavonoid delivery systems. This study investigated the effect and mechanism of zein on the digestive stability of five citrus flavonoids, namely hesperetin (HET), hesperidin (HED), neohesperidin (NHD), naringenin (NEN), and naringin (NIN).RESULTS: Zein enhanced the digestive stability of the five citrus flavonoids, especially that of HET and NEN, during digestion in the stomach and small intestine. Fluorescence spectroscopy results suggested that citrus flavonoids spontaneously quenched the endogenous fluorescence of zein in static quenching mode. The binding of HET, HED and NHD to zein was driven respectively by electrostatic, hydrophobic and electrostatic interaction. However, Van der Waals' force and hydrogen (H)-bond interaction represented the primary driving force for binding NEN, and NIN to zein to form complexes. The binding of the five citrus flavonoids to zein also caused a diverse bathochromic shift in ultraviolet absorbance. Analysis using Fourier-transform infrared and Raman spectroscopy revealed that the binding behavior of the five citrus flavonoids had different effects on changes in the secondary structures, disulfide bonds, and tyrosine exposure of zein. The results were also partially verified by molecular dynamic simulation. CONCLUSIONS: Zein enhanced the digestive stability of the five citrus flavonoids via different binding interactions that was due to the difference in molecular structure of citrus flavonoids.

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“…Hussain et al prepared naringin-loaded β-cyclodextrin nanoparticles to improve its bactericidal ability [ 6 ]. Nallamuthu et al encapsulated naringin in zein/caseinate biopolymers, and the formulation had higher anti-adipogenic activity in 3T3-L1 cells comparing with the native form [ 10 ]. However, most of the work focused on examining the properties of the delivery system, and few studies investigated the stability of naringin in dosage forms.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Physicochemical Characterization, and Antioxidant Activity of Naringin–Silk Fibroin–Alginate Microspheres and Application in Yogurt

Wang

Zhang

et al. 2022

Foods

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Naringin is the major polyphenol in bitter orange peel with antioxidant property. However, its pH sensitivity, low solubility, and bitter taste limit its application in food. In this study, naringin–sodium alginate–silk fibroin microspheres were prepared by the ionic gel method. The loading capacity and encapsulation efficiency of naringin in microspheres were 13.2% and 77.6%, respectively. The morphology of microspheres was characterized by scanning electron microscopy. The X-ray diffractometry and differential scanning calorimetry results showed naringin was amorphous after encapsulation. Fourier-transform infrared spectroscopy and molecular docking analysis confirmed the intermolecular hydrogen bonds between naringin and sodium alginate. Naringin could release from the microspheres continuously under different pH conditions. Compared with free naringin, the 2,2-diphenyl-1-picrylhydrazyl scavenging activity and the stability of naringin microspheres were significantly improved. The application of naringin microspheres in yogurt indicated the precipitation of whey could be effectively reduced and the decline rate of pH was inhibited. The study suggested that naringin encapsulated microspheres were beneficial for improving the shelf life of this bioactive product as well as providing a new idea for functional yogurt.

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Formulation of Naringin Encapsulation in Zein/Caseinate Biopolymers and its Anti-adipogenic Activity in 3T3-L1 Pre-adipocytes

Cited by 15 publications

References 43 publications

Fabrication, characterization of carboxymethyl konjac glucomannan/ovalbumin-naringin nanoparticles with improving in vitro bioaccessibility

Fabrication, characterization of carboxymethyl konjac glucomannan/ovalbumin-naringin nanoparticles with improving in vitro bioaccessibility

Zein enhanced the digestive stability of five citrus flavonoids via different binding interaction

Preparation, Physicochemical Characterization, and Antioxidant Activity of Naringin–Silk Fibroin–Alginate Microspheres and Application in Yogurt

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