The circulating vascular endothelial growth factor is only marginally associated with an increased risk for atherosclerosis

Pauli, Natalia; Kuligowska, Agnieszka; Krzystolik, Andrzej; Dziedziejko, Violetta; Safranow, Krzysztof; Rać, Monika; Chlubek, Dariusz

doi:10.23736/s0026-4725.20.04995-6

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…In atherosclerosis, carotid intima-media thickness is negatively correlated with levels of VEGF-A and ET-1 and positively-with NO level; thus, VEGF-A could serve as a marker to monitor atherosclerosis and related pathologies [58]. However, a recent study on Caucasian patients with early-onset CAD suggests that the level of circulating VEGF is only marginally associated with an increased risk for atherosclerosis [59]. Thus, the causative role of VEGF-A in atherosclerosis requires further investigation (Figure 3).…”

Section: Atherosclerosismentioning

confidence: 99%

The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets

Dabravolski

Khotina

Omelchenko

et al. 2022

IJMS

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The vascular endothelial growth factor (VEGF) family, the crucial regulator of angiogenesis, lymphangiogenesis, lipid metabolism and inflammation, is involved in the development of atherosclerosis and further CVDs (cardiovascular diseases). This review discusses the general regulation and functions of VEGFs, their role in lipid metabolism and atherosclerosis development and progression. These functions present the great potential of applying the VEGF family as a target in the treatment of atherosclerosis and related CVDs. In addition, we discuss several modern anti-atherosclerosis VEGFs-targeted experimental procedures, drugs and natural compounds, which could significantly improve the efficiency of atherosclerosis and related CVDs’ treatment.

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Section: Atherosclerosismentioning

confidence: 99%

The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets

Dabravolski

Khotina

Omelchenko

et al. 2022

IJMS

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Section: Introductionmentioning

confidence: 99%

“…Therefore, from a physiological point of view, it is more appropriate to consider these processes together. 10 The main marker responsible for proliferation and migration of smooth muscle cells of the vascular wall is platelet growth factor -PDGF BB -while for endothelial cells it is vascular endothelial growth factor -VEGF A165. 11 As a result of our primary studies, a number of hypotheses were put forward, specifically, with regard to the relationship between biomarkers of apoptosis and cell proliferation and the possibility that these markers could be predictors of the progression of atherosclerosis after open interventions on the arteries of the lower extremities.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive assessment of markers of apoptosis and cell proliferation during progression of atherosclerosis after surgery in patients with peripheral arterial disease

2023

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Background Determination of predictors that can affect development of atherosclerosis progression in the postoperative period is an urgent problem in vascular surgery. Objectives Integrated assessment of markers of apoptosis and cell proliferation in atherosclerotic lesions and their progression after surgery in patients with peripheral arterial diseases. Methods The investigation included 30 patients with stage IIB-III peripheral arterial disease. All patients have undergone open surgical interventions on the arteries of the aorto-iliac and femoral-popliteal segments. During these interventions, intraoperative specimens were obtained from the vascular wall with atherosclerotic lesions. The following values were evaluated: VEGF А165, PDGF BB, and sFas. Samples of normal vascular wall were obtained from post-mortem donors and used as a control group. Results The levels of Bax and p53 were increased (p<0.001) in samples from arterial wall with atherosclerotic plaque, while sFas values were reduced (p<0.001), compared to their levels in control samples. Values of PDGF BB and VEGF A165 were 1.9 and 1.7 times higher in atherosclerotic lesion samples (p=0.001), in comparison with the control group. The levels of p53 and Bax were increased against a background of reduced sFas levels in samples with progression of atherosclerosis compared to their baseline values in samples with atherosclerotic plaque (p<0.05). Conclusions Initially increased values of the Bax marker against a background of reduced sFas values in vascular wall samples from patients with peripheral arterial disease is associated with risk of atherosclerosis progression in the postoperative period.

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Vaping Cardiovascular Health Risks: an Updated Umbrella Review

Peruzzi

Biondi‐Zoccai

Carnevale

et al. 2020

Curr Emerg Hosp Med Rep

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Purpose of Review Modified risk products (MRP) such as electronic vaping cigarettes (EVC) and heat-not-burn cigarettes (HNBC) are alternatives to traditional combustion cigarettes (TCC) with an expanding consumer base. Yet, their cardiovascular health risks are still unclear. We aimed to summarize the evidence base on this topic by conducting an updated umbrella review. Recent Findings We identified 7 systematic reviews, totaling 183 studies and reports, ranging from in vitro and in animal studies to clinical studies in apparently healthy volunteers and patients at risk of cardiovascular disease. Overall, acute EVC use was associated with several toxic effects at molecular, cellular, tissue, organ, and system level. In addition, EVC impacted adversely on blood pressure (BP) management, caused tachycardia, and worsened arterial stiffness. Finally, EVC use was associated with an increased risk of adverse clinical events, including atrial fibrillation and myocardial infarction, even if the causal link is still debated. Most reviews highlighted that the detrimental impact of EVC was of lesser magnitude of that of TCC. In addition, the differential impact of liquids and nicotine was not clearly disentangled. Finally, no review included studies on HNBC. Summary The present umbrella review suggests that EVC, and likely HNBC, despite clearly causing an increase in overall cardiovascular risk, may represent a temporary lesser evil than TCC in a risk-reduction or risk-modification strategy, aiming for eventual abstinence from all tobacco or nicotine products. Keywords Cardiovascular disease. Electronic cigarette. Electronic vaping cigarette. Heat-not-burn cigarette. Smoking Giving up smoking is the easiest thing in the world. I know because I've done it thousands of times.

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The circulating vascular endothelial growth factor is only marginally associated with an increased risk for atherosclerosis

Cited by 4 publications

References 36 publications

The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets

The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets

Comprehensive assessment of markers of apoptosis and cell proliferation during progression of atherosclerosis after surgery in patients with peripheral arterial disease

Vaping Cardiovascular Health Risks: an Updated Umbrella Review

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