Background
Little clinical research on new‐generation heat‐not‐burn cigarettes (
HNBC
) in comparison with electronic vaping cigarettes (
EVC
) and traditional tobacco combustion cigarettes (
TC
) has been reported. We aimed to appraise the acute effects of single use of
HNBC
,
EVC,
and
TC
in healthy smokers.
Methods and Results
This was an independent, cross‐over, randomized trial in 20
TC
smokers, with allocation to different cycles of
HNBC
,
EVC
, and
TC
. All participants used all types of products, with an intercycle washout of 1 week. End points were oxidative stress, antioxidant reserve, platelet activation, flow‐mediated dilation, blood pressure, and satisfaction scores. Single use of any product led to an adverse impact on oxidative stress, antioxidant reserve, platelet function, flow‐mediated dilation, and blood pressure.
HNBC
had less impact than
EVC
and
TC
on soluble Nox2‐derived peptide (respectively,
P
=0.004 and 0.001), 8‐iso‐prostaglandin F2α‐
III
(
P
=0.004 and <0.001), and vitamin E (
P
=0.018 and 0.044).
HNBC
and
EVC
were equally less impactful than
TCs
on flow‐mediated dilation (
P
=0.872 for
HNBC
versus
EVC
), H
2
O
2
(
P
=0.522), H
2
O
2
breakdown activity (
P
=0.091), soluble
CD
40 ligand (
P
=0.849), and soluble P‐selectin (
P
=0.821). The effect of
HNBC
and, to a lesser extent
EVC
, on blood pressure was less evident than that of
TC
, whereas
HNBC
appeared more satisfying than
EVC
(all
P
<0.05).
Conclusions
Acute effects of
HNBC
,
EVC,
and
TC
are different on several oxidative stress, antioxidant reserve, platelet function, cardiovascular, and satisfaction dimensions, with
TCs
showing the most detrimental changes in clinically relevant features.
Clinical Trial Registration
URL
:
http://www.clinicaltrials.gov
. Unique identifier:
...