The chromatographic chamber plays a significant role in plate development. The main characteristics of planar chromatography chromatographic processes (the efficiency, the duration of plate development, the separation factor and the analyzed compounds' retention) are studied in this article in two new variants of chromatographic chambers proposed in our laboratory: the O-chamber with a zero gas volume and the S min -chamber with an ultra-small gas volume (the distance between the adsorption layer of the plate and the side cover is 0.1-0.2 mm). The S min -chamber application permits reducing the duration of TLC plate development by more than 25% (in comparison with the identical process in an N-chamber). The possibility of using the S min -chamber for saturated TLC implementation is also demonstrated. A new, simple S min -chamber is expedient for use in practical TLC.