The cholesterol lowering efficacy of plant stanol ester yoghurt in a Turkish population: a double-blind, placebo-controlled trial

Abstract

BackgroundWe evaluated the cholesterol lowering efficacy of low-fat spoonable yoghurt with 1.9 g/d plant stanols as esters on plasma lipid profiles of Turkish subjects with mild to moderate hypercholesterolemia.MethodsUsing a randomised, double-blind, placebo-controlled study design, intervention (n = 35) and control (n = 35) groups consumed either 115 g low-fat yoghurt with 1.9 g/d plant stanols as esters or placebo yoghurt, respectively, for 4 weeks. Seventy subjects with untreated mild to moderate hypercholesterolemia (aged 23-65 years) were recruited. Changes in the lipid profile, including lipoproteins, apolipoproteins, and triglycerides, and anthropometric measurements were monitored at screening, baseline, and at the end of the second, third, and fourth weeks of intervention. The general linear model repeated measures procedure was used to test differences in the repeated continuous variables between study groups.ResultsSerum total cholesterol (4.6%), LDL cholesterol (6.3%), and non-HDL cholesterol (6.2%) concentrations were reduced significantly from baseline in the plant stanol group compared to the control group (p = 0.007, p = 0.005 and p = 0.005, respectively). A variation in the response of serum total and LDL cholesterol between the subjects in plant stanol group was obtained. No clinically significant change in anthropometrical measurements was observed during the intervention.ConclusionsThe spoonable low-fat yoghurt with 1.9 g/d plant stanols as esters lowered total, LDL, and non-HDL cholesterol levels in Turkish subjects with mild to moderate hypercholesterolemia. Nevertheless variation in baseline cholesterol levels, genetic predisposition of the subjects and compliance may contribute to a large individual variability.

Long-term Effects of Plant Stanols on the Lipid Profile of Patients With Hypercholesterolemia. A Randomized Clinical Trial

“…8,9,19 Our results match those of a recent meta-analysis evaluating the effects of phytosterols incorporated in 9 distinct food types and consumed for different durations. 20 Previous studies with stanols administered in yogurt form have shown similar 21 or inferior 22 LDL-C and TC reductions to those of our study. A similar decrease has also been seen upon supplementation of other foods with stanols.…”

Efecto a largo plazo de los estanoles vegetales en el perfil lipídico de pacientes con hipercolesterolemia. Ensayo clínico aleatorizado

“…Al comparar la modificació n de las cifras de los diferentes pará metros lipídicos entre ambos grupos durante el seguimiento, se observó una mayor reducció n media del CT en el grupo de intervenció n tanto a los 3 meses (15,5 [IC95%, 5,3-25,8] mg/dl; p = 0,003) como a los 12 meses (18,1 [IC95%, 8,1-28,2] mg/dl; p < 0,001). La disminució n del cLDL tambié n era superior en los que tomaron estanoles al cabo de 3 meses (13,3 [IC95%,3,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)8] mg/dl; p = 0,006) y a los 12 meses (13,7 [IC95%, 3,2-24,1] mg/dl; p = 0,011). No aparecieron diferencias estadísticamente significativas entre uno y otro grupo respecto al cHDL, triglicé ridos, CT/cHDL y cLDL/cHDL.…”

“…Similares resultados se han indicado en varios metaná lisis 22,30 , aunque explicaban el efecto de la edad en funció n del de la cifras iniciales de cLDL, mientras que en el presente estudio el efecto de la edad se mantiene al excluir el cLDL basal del modelo de regresió n. La distribució n etaria de la muestra podría tener alguna relació n con estos resultados.…”

Is consuming yoghurt associated with weight management outcomes? Results from a systematic review

“…The efficacy of yoghurt has been investigated in a wide range of separate and overlapping outcomes including weight-related outcomes, 5 type 2 diabetes, 6 cardiovascular disease risk, 7 the risk of cancer, 8 gastrointestinal health, 9 diarrhoea symptoms, 10 malnutrition 11 and overall mortality. 12 Systematic reviews (some involving meta-analysis) have been conducted in relation to only a few of these outcomes.…”