The chemoreactomic analysis of the central mechanisms of action of non-steroidal anti-inflammatory drugs

Громова, О. А.; Torshin, I. Yu.; Путилина, М. В.; Стаховская, Л В; Рудаков, К. В.

doi:10.17116/jnevro202012001170

Cited by 6 publications

(1 citation statement)

References 22 publications

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“…РАН Ю. И. Журавлёва. Методы применения хемореактомной технологии для анализа различных лекарств [8][9][10] и их сочетаний [8,11,12] были более подробно ранее и представлены на интернетресурсе www.chemoinformatics.ru.…”

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Chemoreactome analysis of natural and synthetic statins indicates a more favorable safety proﬁle of monacolin K

Gromova

Torshin

2022

jour

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Increasing the eﬀectiveness and safety of pharmacotherapy of hyperlipidemia is an urgent task of gastroenterology and cardiology. Statin drugs can diﬀer signiﬁ cantly not only in the eﬀectiveness of lipid proﬁle normalization, but also in the spectrum of side eﬀects. The paper presents the results of a comparative chemoreactomic analysis of “natural” statins (monacolins K, J, L, simvastatin) and synthetic statins (atorvastatin, ﬂ uvastatin). It is important to note that “natural” monacolin K does not cause the negative metabolic changes characteristic of synthetic statins. In general, the assessments of the accumulation of the studied molecules in various human cells and tissues, eﬀects on the human metabolome and proteome, and assessments of the side eﬀects of therapy indicate a more favorable safety proﬁle of the “natural” statin monacolin K.

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Section: Introductionunclassified

Chemoreactome analysis of natural and synthetic statins indicates a more favorable safety proﬁle of monacolin K

Gromova

Torshin

2022

jour

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Investigation of the anticonvulsant and remyelinating potential of dexketoprofen on a rat model of primary generalized seizures

Громова

Демидов

Калачева

et al. 2020

RJTAO

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Objective: to investigate the effect of dexketoprofen on the severity of seizures on a rat model of primary generalized seizures caused by thiosemicarbazide; to evaluate the neuroprotective effect of the drug.Material and methods. The investigation was conducted on 72 male albino rats weighing 200–300 g. The animals were given dexketoprofen and/or comparison drugs (gabapentin, sodium valproate) for 5 days, after which the seizure model was reproduced. The effects of the drugs were evaluated from a set of neurological tests and the results of a histopathological examination of the brain.Results and discussion. Dexketoprofen reduced the severity, duration, and number of primary generalized seizures and potentiated the anticonvulsant effects of gabapentin and sodium valproate. Histopathological and morphometric examinations of the rat brain showed that dexketoprofen inhibited the formation of irreversible neuronal changes (27.2%; control, 55.7%), by transferring them into reversible changes (47.7%; control, 21.8%).Conclusion. The investigation made it possible to conclude that dexketoprofen had a moderate neuroprotective effect neurologically and morphometrically verified.

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Comparative chemoreactome analysis of the synergism of vinpocetine, piracetam, and cinnarizine molecules

Громова¹,

Torshin²

2021

Z. nevrol. psikhiatr. im. S.S. Korsakova

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The chemoreactomic analysis of the central mechanisms of action of non-steroidal anti-inflammatory drugs

Cited by 6 publications

References 22 publications

Chemoreactome analysis of natural and synthetic statins indicates a more favorable safety proﬁle of monacolin K

Chemoreactome analysis of natural and synthetic statins indicates a more favorable safety proﬁle of monacolin K

Investigation of the anticonvulsant and remyelinating potential of dexketoprofen on a rat model of primary generalized seizures

Comparative chemoreactome analysis of the synergism of vinpocetine, piracetam, and cinnarizine molecules

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