The chemistry of chelating agents in medical sciences

Bulman, Robert A.

doi:10.1007/3-540-17881-3_3

Cited by 38 publications

(7 citation statements)

References 215 publications

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“…2S Of these chelating agents the esters of 1,2-ethylenebis(o-hydroxyphenylglycine), EHPG, 5, seemed like good substitutes but further research and testing of these compounds was halted because of their toxicity. Another compound, the methyl ester of HBED, 2, now seems to offer considerable promise since it can be administered orally and is quite effective in the removal of iron from the body.26,27 Another chelating agent which is claimed to be very effective on a number of human (volunteer) patients is 1,2-dimethyl-3-hydroxy-4-pyridinone, DMHP or Ll, 8. This has been reported to be effective even though it is a bidentate agent and its 3:1 iron chelates should dissociate considerably at low concentration.…”

Section: Iron Overloadmentioning

confidence: 99%

Medical Applications of Metal Complexes

Martell

Hancock

1996

Metal Complexes in Aqueous Solutions

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It is the purpose of this chapter to use the principles that have been described in previous chapters on metal complexes, chelates, and macro cyclic compounds to develop an understanding of the use of metal complexes or ligands for medical purposes. Previous chapters have emphasized the factors involved in designing metal complexes with maximum stability, and with a large degree of selectivity. Both of these factors are important in biological systems because of the fact that all metal ions are subject to interaction with the natural ligands that are present in body fluids for the purpose of storage, transport and the regulation of the activity of natural metal ions that are needed for various mctabolic purposes. Therefore, in order for a ligand to be effective in biological systems, or a metal complex to retain its integrity in competition with natural carriers, the thermodynamic stability of the complex in question must be maximized. When a ligand is designed to remove a certain metal ion because it has reached toxic levels, it must be as selective as possible for that metal ion so as not to disturb thc metals that are naturally present. However, high thermodynamic stability and selectivity are not the sole requirements of the ligand or of the metal complex being considered, because there are many other factors in biological systems which must be taken into consideration. Such factors include the method of administration (oral, sub-cutaneous, intravenous injection, etc.), bioavailability, membrane permeability, toxicity, and rapid elimination of the ligand and its metal chelate without spreading the undesired metal to other organs throughout the body. It will be the philosophy of this chapter that the thermodynamic stability of a metal chelate should be maximized, and the principles described in this book will be used for this purpose. While ligand design to achieve these purposes seems fairly straightforward, the other factors of importance in biological systems such as toxicity, bioavailability and membrane permeability are not as easily predicted. Therefore, many complexes that meet the stability requirements cannot be used in biological systems because they fail to meet the other biological requirements described above.A few examples of metal complexes will serve to illustrate this point. Macrocycles such as cyclam which form very stable copper complexes (with stability constants of the order of ~ 1028) were found to be considerably less effective in enhancing urinary excretion of copper than were the polyamines (with copper stability constants of ~ 1020-1024). This is possibly due to differences in bioavailability of the two types of complexing ligands, as well as the fact that the rate at which Cu(II) cyclam complexes form is very slow. Another example is the catechol group containing ligands such as the 149 A. E. Martell et al., Metal Complexes in Aqueous Solutions

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Section: Iron Overloadmentioning

confidence: 99%

Medical Applications of Metal Complexes

Martell

Hancock

1996

Metal Complexes in Aqueous Solutions

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“…In the last several decades, great attention has been dedicated to diaminopolycarboxylate ligands structurally related to edta (ethylenediamine-N,N,N',N'-tetraacetate anion) and their metal complexes because of their importance in chemistry, medicine, and agriculture (Anderegg, 1987;Bulman, 1987;Douglas and Radanović, 1993). In different forms, edta has been used as a powerful antimicrobial agent, which manifests significant activity against a range of clinically important microorganisms, including different Gram-negative and Gram-positive bacteria, yeasts, amoeba, and fungi (Brown and Richards, 1965;Kite and Hatton, 2014).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and spectroscopic characterization of new solid solution containing Mg(II) and Cu(II) complexes with hexadentate 1,3-propanediaminen, N,N’,N’-tetraacetate (1,3-pdta) ligand: In vitro antifungal activity of 1,3-pdta-Cu(II) complexes

Stanojević

Gitarić

Asanin

et al. 2020

Facta Univ Phys Chem Technol

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New solid solution containing Mg(II) and Cu(II) complexes with hexadentate 1,3-propanediamine-N,N,N?,N?-tetraacetate ligand (1,3-pdta), [Mg(H2O)6] [Mg0.5Cu0.5(1,3-pdta)].2H2O was synthesized and structurally characterized by elemental microanalyses, molar conductivity, and spectroscopic (IR and UV-Vis) measurements. The spectroscopic data of [Mg(H2O)6][Mg0.5Cu0.5(1,3-pdta)].2H2O were compared with those for [Mg(H2O)6][Cu(1,3-pdta)].2H2O complex of the known molecular structure determined by single-crystal X-ray diffraction analysis. In vitro growth inhibition activity of [Mg(H2O)6][Mg0.5Cu0.5(1,3-pdta)].2H2O and [Mg(H2O)6][Cu(1,3-pdta)].2H2O against Colletotrichum acutatum and their effects on this fungus sporulation level are investigated. The obtained results showed that the highest percentage of inhibition for mycelium growth was achieved at a concentration of 500 ?g/mL for the investigated complexes. The biological activities of the investigated complexes were compared with those for the commercial formulation of fungicide captan (Method 480 SC).

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“…[16][17][18][19] Poly(methyl vinyl ether-altmaleic anhydride) P(MVE-alt-MA), its derivatives and complexes have many important applications such as in the capture of influenza A and B viruses, 20 nasalsustained systems, 21 capture of respiratory syncytial viruses, 22 immune system activators, 23 isolation of nucleic acids 24 and generic capture of viruses. 25 * For correspondence Complexation of metal ions in solution is a significant process in several areas, for example, design of ligands as therapeutic reagents for the treatment of metal intoxication, 26,27 design of antibiotics that owe their antibiotic action to specific metal complexation, 28 design of complexes to act as imaging agents, 29 design of functional groups for chelating ion-exchange materials, 30 and catalysts. 31 The scope of applications of metal complexation of polymers has a tendency to increase considerably in the near future.…”

Section: Introductionmentioning

confidence: 99%

Cu(II), Zn(II) and Mn(II) complexes of poly(methyl vinyl ether-alt-maleic anhydride). Synthesis, characterization and thermodynamic parameters

Mazi

Gulpinar

2014

J Chem Sci

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The complexes of poly(methyl vinyl ether-alt-maleic anhydride) (poly(MVE-alt-MA)) with Zn(II), Mn(II) and Cu(II) ions were synthesized from the reaction of the aqueous solution of copolymer and metal(II) chlorides at different temperatures ranging from 25 • to 40 • C. Elemental analysis of the metal-polymer complexes suggests that the metal to ligand ratio is 1:1. The formation constants of each complex were determined by the mol-ratio method. UV-Vis studies showed that the complex formation tendency increased in the following order: Zn(II) > Cu(II) > Mn(II). This order was confirmed by the Irving-William series and Pearson's classification. The IR spectral data indicated the metal ions to be coordinated through the hydroxyl groups of the hydrolysed maleic anhydride. The intrinsic viscosity and thermal properties of the copolymer and metal-polymer complexes and their thermal stability are discussed.

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The chemistry of chelating agents in medical sciences

Cited by 38 publications

References 215 publications

Medical Applications of Metal Complexes

Medical Applications of Metal Complexes

Synthesis and spectroscopic characterization of new solid solution containing Mg(II) and Cu(II) complexes with hexadentate 1,3-propanediaminen, N,N’,N’-tetraacetate (1,3-pdta) ligand: In vitro antifungal activity of 1,3-pdta-Cu(II) complexes

Cu(II), Zn(II) and Mn(II) complexes of poly(methyl vinyl ether-alt-maleic anhydride). Synthesis, characterization and thermodynamic parameters

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