The chemistry and biology of fungal meroterpenoids (2009–2019)

Jiang, Minghua; Wu, Zhenger; Liu, Lan; Chen, Senhua

doi:10.1039/d0ob02162h

Cited by 89 publications

(85 citation statements)

References 466 publications

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“…(iii) Gozari et al [31] reviewed only 190 meroterpenoids from bacteria and fungi that showed significant preclinical effects. (iv) Jiang et al [32] summarized the described 1585 fungal meroterpenoids in 2009-2019.…”

Section: Introductionmentioning

confidence: 99%

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

et al. 2021

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Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.

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Section: Introductionmentioning

confidence: 99%

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

et al. 2021

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“…Polysaccharides and triterpenoids are representative of the important biologically active components of Ganoderma ( Wang et al, 2020 ). Recent ongoing research studies exploring Ganoderma demonstrated that it contains meroterpenoid components that possess extensive biological activities, such as renal protection and neuroprotection, anti-inflammation, -tumor and -oxidation properties, and analgesic effects ( Jiang et al, 2021 ). These studies led to a deeper understanding of the components of Ganoderma and insight into active ingredients responsible for its traditional medical properties.…”

Section: Introductionmentioning

confidence: 99%

Terminal Cyclohexane-Type Meroterpenoids from the Fruiting Bodies of Ganoderma cochlear

Qin

et al. 2021

Front. Chem.

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Eleven new cyclohexane-type meroterpenoids (1, 3–5, 7, 8, 11–15) and four known similar meroterpenoids (2, 6, 9, and 10) were isolated from Ganoderma cochlear. Their structures and absolute configurations at stereogenic centers were elucidated by using HRESIMS, NMR spectroscopy and computational methods. In addition, the structure of the known meroterpenoid, cochlearol G (2), was revised, and the absolute configurations at the stereogenic centers of known meroterpenoids 9 and 10 were determined. All the isolated meroterpenoids were evaluated for their activities against renal fibrosis and triple negative breast cancer, and their insulin resistance. The results of the renal fibrosis study showed that meroterpenoid 11 inhibits over-expression of fibronectin, collagen I and α-SMA. Results of the wound healing study revealed that 4, 6 and 8 significantly inhibit migration of BT549 cells. Observations made in Western blotting experiments showed that 6 decreases the levels of TWIST1 and ZEB1, and increases the level of E-cadherin. Finally, meroterpenoids 7, 9, 11, and 15 significantly up-regulate p-AMPK protein expression in normal L6 myotubes cells.

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“…Fungal meroterpenoids are secondary metabolites from mixed terpene-biosynthetic origins. 386 Based on their nonterpenoid starting scaffolds, meroterpenoids were classified into four categories: polyketide–terpenoid, indole-terpenoid, shikimate-terpenoid, and miscellaneou meroterpenoids.…”

Section: Secondary Metabolites From Mangrove Fungimentioning

confidence: 99%

Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

et al. 2022

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The chemistry and biology of fungal meroterpenoids (2009–2019)

Abstract: The structural features, biological activities, and fungal biodiversity of 1585 new meroterpenoids were comprehensively overviewed (2009–2019).

Cited by 89 publications

References 466 publications

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

Terminal Cyclohexane-Type Meroterpenoids from the Fruiting Bodies of Ganoderma cochlear

Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

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