Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

Chen, Senhua; Cai, Runlin; Liu, Zhaoming; Cui, Hui; She, Zhigang

doi:10.1039/d1np00041a

Cited by 98 publications

(102 citation statements)

References 489 publications

(899 reference statements)

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“…Mangrove endophytic fungi, the second largest ecological group of marine fungi, have been reported to produce thousands of new metabolites until now ( Chen et al, 2021 ; Chen et al, 2022 ). Over the past 2 decades, our group continues to explore bioactive novel structures from mangrove endophytic fungi ( Huang et al, 2013 ; Xiao et al, 2013 ; Liu et al, 2016 ; Cui et al, 2017 ; Cai et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2

et al. 2022

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Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E (1) and F (2), one new chromone fusarimone A (5), two new benzofurans fusarifurans A (9) and B (10), three new isocoumarins fusarimarins A–C (11–13), as well as five known analogues 3, 4, 6–8 and 14 were isolated from mangrove endophytic fungus Fusarium sp. 2ST2. Their structures and absolute configurations were established by spectroscopic analysis, density functional theory-gauge invariant atomic orbital NMR calculation with DP4+ statistical analysis, and electronic circular dichroism calculation. Compounds 1 and 2 showed significant cytotoxicity against human A549 cell lines with IC50 values of 8.7 and 4.3 μM, respectively.

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Section: Introductionmentioning

confidence: 99%

Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2

et al. 2022

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“…Mangrove is a special marine ecosystem that occurs in tropical and subtropical intertidal estuarine zones, and is characterized by high salinity and rich organic matter [5], which makes it an extremely diverse microbial resource. Mangrove-associated fungi, as the second-largest ecological group of marine fungi [6], have proven to be a rich source of natural products, with unique chemical structures and diverse pharmacological activities. Up to now, a large number of metabolites produced by mangrove fungi have been reported, including alkaloids, macrolides, polyketides, quinones, terpenes, and so on [6], which displayed diverse bioactivity, such as antibacterial, insecticidal, antioxidant, and cytotoxic, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Mangrove-associated fungi, as the second-largest ecological group of marine fungi [6], have proven to be a rich source of natural products, with unique chemical structures and diverse pharmacological activities. Up to now, a large number of metabolites produced by mangrove fungi have been reported, including alkaloids, macrolides, polyketides, quinones, terpenes, and so on [6], which displayed diverse bioactivity, such as antibacterial, insecticidal, antioxidant, and cytotoxic, etc. These findings indicate that mangrove-derived fungi may possess great potential to produce novel and active secondary metabolites.…”

Section: Introductionmentioning

confidence: 99%

Citreobenzofuran D–F and Phomenone A–B: Five Novel Sesquiterpenoids from the Mangrove-Derived Fungus Penicillium sp. HDN13-494

Chang

Che

et al. 2022

Marine Drugs

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Five new sesquiterpenoids, citreobenzofuran D–F (1–3) and phomenone A–B (4–5), along with one known compound, xylarenone A (6), were isolated from the culture of the mangrove-derived fungus Penicillium sp. HDN13-494. Their structures were deduced from extensive spectroscopic data, high-resolution electrospray ionization mass spectrometry (HRESIMS), and electronic circular dichroism (ECD) calculations. Furthermore, the absolute structures of 1 were determined by single-crystal X-ray diffraction analysis. Citreobenzofuran E–F (2–3) are eremophilane-type sesquiterpenoids with rare benzofuran frameworks, while phomenone A (4) contains a rare thiomethyl group, which is the first report of this kind of sesquiterpene with sulfur elements in the skeleton. All the compounds were tested for their antimicrobial and antitumor activity, and phomenone B (5) showed moderate activity against Bacillus subtilis, with an MIC value of 6.25 μM.

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“…The influence of bioactive compounds from natural sources on human life has challenged scientists to research new environmental contexts and the associated biological diversity [ 1 ]. The ocean, as the largest frontier in biological exploration, represents one of the most favorable reservoirs of organisms producing secondary metabolites with biological activities [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

New Sorbicillinoids with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus Hypocrea jecorina H8

Liu

et al. 2022

Marine Drugs

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Four new dimeric sorbicillinoids (1–3 and 5) and a new monomeric sorbicillinoid (4) as well as six known analogs (6–11) were purified from the fungal strain Hypocrea jecorina H8, which was obtained from mangrove sediment, and showed potent inhibitory activity against the tea pathogenic fungus Pestalotiopsis theae (P. theae). The planar structures of 1–5 were assigned by analyses of their UV, IR, HR-ESI-MS, and NMR spectroscopic data. All the compounds were evaluated for growth inhibition of tea pathogenic fungus P. theae. Compounds 5, 6, 8, 9, and 10 exhibited more potent inhibitory activities compared with the positive control hexaconazole with an ED50 of 24.25 ± 1.57 µg/mL. The ED50 values of compounds 5, 6, 8, 9, and 10 were 9.13 ± 1.25, 2.04 ± 1.24, 18.22 ± 1.29, 1.83 ± 1.37, and 4.68 ± 1.44 µg/mL, respectively. Additionally, the effects of these compounds on zebrafish embryo development were also evaluated. Except for compounds 5 and 8, which imparted toxic effects on zebrafish even at 0.625 μM, the other isolated compounds did not exhibit significant toxicity to zebrafish eggs, embryos, or larvae. Taken together, sorbicillinoid derivatives (6, 9, and 10) from H. jecorina H8 displayed low toxicity and high anti-tea pathogenic fungus potential.

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Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

Abstract: The mangrove forests are a complex ecosystem occurring at tropical and subtropical intertidal estuarine zones and nourish a variety of fungi that produce 1387 secondary metabolites with the feature of source, chemical and bioactive diversity.

Cited by 98 publications

References 489 publications

Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2

Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2

Citreobenzofuran D–F and Phomenone A–B: Five Novel Sesquiterpenoids from the Mangrove-Derived Fungus Penicillium sp. HDN13-494

New Sorbicillinoids with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus Hypocrea jecorina H8

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