Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2

Abstract

Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E (1) and F (2), one new chromone fusarimone A (5), two new benzofurans fusarifurans A (9) and B (10), three new isocoumarins fusarimarins A–C (11–13), as well as five known analogues 3, 4, 6–8 and 14 were isolated from mangrove endophytic fungus Fusarium sp. 2ST2. Their structures and absolute configurations were established by spectroscopic analysis, density functional theory-gauge invariant atomic orbital NMR calculation with DP4+ statistical analysis, and electronic circular dichroism calculation. Compounds 1 and 2 showed significant cytotoxicity against human A549 cell lines with IC50 values of 8.7 and 4.3 μM, respectively.

Pyrrospirones K–Q, Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus Penicillium sp. SCSIO 41512

“…Thus, the planar structure of 1 was established as shown. As is known, peroxy hemiacetals are only observed in a few natural products, such as artemisinin and artediffusin (tehranolide) from the Artemisia genus, 19 EBC-324 from Croton insularis, 20 fusarisetins E and F from the fungus Fusarium sp., 21 and coronarin C from Hedychium coronarium. 22 The relative configuration of 1 was elucidated by analysis of the NOESY spectrum (Figure S7).…”

Anti-Tumor Secondary Metabolites Originating from Fungi in the South China Sea’s Mangrove Ecosystem

“…From another mangrove genus Fusarium sp. 2ST2, aspergisocoumrin A ( 4 ) was also derived and inhibited human lung carcinoma cells, with IC 50 values of 6.2 ± 0.2 μM [ 19 ].…”

“…4H-1-benzopyran-4-one-2,3-dihydro-5-hydroxy-8-(hydroxylmethyl)-2-methyl ( 10 ) was derived from Fusarium sp. 2ST2 accompanied by aspergisocoumrin A ( 4 ), showing the same inhibition against A549 and MDA-MB-435 cells (IC 50 5.6 and 3.8 μM, respectively) [ 19 ].…”

“…Fusarisetins E-F ( 73 – 74 ) were two novel 3-decalinoyltetramic acid derivatives with the structure of a peroxide bridge derived from Fusarium sp. 2ST2, showing obvious inhibitory effects on A549 cells, with IC 50 values of 8.7 to 4.3 μM [ 19 ]. The mangrove-derived fungus Cladosporium sp.…”

Diversified Polyketides With Anti-inflammatory Activities From Mangrove Endophytic Fungus Daldinia eschscholtzii KBJYZ-1

“…Mangrove endophytic fungi have proven to be a promising source of novel chemical backbones and bioactive metabolites owing to extreme environments (tidal flooding, high salinity, anaerobic soil, and high temperature) of mangroves (Chen S. et al, 2022 ; Chen Y. et al, 2022 ). Daldinia eschscholtzii is an endophytic fungus isolated commonly from mangrove plants (Yang et al, 2017 ).…”