Anti-Tumor Secondary Metabolites Originating from Fungi in the South China Sea’s Mangrove Ecosystem

Luo, Yuyou; Luo, Xun; Zhang, Tong; Liu, Siyuan; Liu, Shuping; Ma, Yuxin; Wang, Zongming; Jin, Xiaobao; Liu, Jing; Wang, Xin

doi:10.3390/bioengineering9120776

Cited by 3 publications

(3 citation statements)

References 83 publications

(91 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to their marine origin (vide supra), fungi are ubiquitous on land. A review of the fungal genus Trichoderma has appeared, and the antitumor fungal metabolites from the mangrove ecosystem in the South China Sea is summarized …”

Section: Terrestrial Fungimentioning

confidence: 99%

“…A review of the fungal genus Trichoderma has appeared, 156 and the antitumor fungal metabolites from the mangrove ecosystem in the South China Sea is summarized. 157 Two new azaphilone alkaloids, peniphilones A (329) and B (330), are produced by the fungus Penicillium maximae 17F4201 found on an unidentified plant in Japan. Neither compound is cytotoxic toward HeLa cells nor shows antibacterial activity to Bacillus cereus, Escherichia coli, and Candida albicans at 50 μM.…”

Section: ■ Terrestrial Fungimentioning

confidence: 99%

See 1 more Smart Citation

A Survey of Recently Discovered Naturally Occurring Organohalogen Compounds

Gribble

2024

J. Nat. Prod.

View full text Add to dashboard Cite

The discovery of naturally occurring organohalogen compounds has increased astronomically in the 55 years since they were first discovered�from fewer than 50 in 1968 to a combined 7,958 described examples in three comprehensive reviews. The present survey, which covers the period 2021−2023, brings the number of known natural organohalogens to approximately 8,400. The organization is according to species origin, and coverage includes marine and terrestrial plants, fungi, bacteria, marine sponges, corals, cyanobacteria, tunicates, and other marine organisms.

show abstract

Section: Terrestrial Fungimentioning

confidence: 99%

Section: ■ Terrestrial Fungimentioning

confidence: 99%

A Survey of Recently Discovered Naturally Occurring Organohalogen Compounds

Gribble

2024

J. Nat. Prod.

View full text Add to dashboard Cite

show abstract

“…Among nontoxigenic fungi, endophytic fungi, i.e., symbiotic fungi that colonize various tissues of their host, most often plants, deserve special attention. Endophytes are an excellent source of bioactive compounds with anticancer activity, including those against lung cancer [52][53][54][55][56][57][58]. In addition to endophytic fungi, bioactive metabolites with anticancer properties against lung cancer are synthesized by marine-derived fungi [59][60][61][62] (Table 1).…”

Section: Secondary Metabolites Synthesized By Endophytes and Marine-d...mentioning

confidence: 99%

Natural Bacterial and Fungal Peptides as a Promising Treatment to Defeat Lung Cancer Cells

et al. 2023

View full text Add to dashboard Cite

Despite the increasing availability of modern treatments, including personalized therapies, there is a strong need to search for new drugs that will be effective in the fight against cancer. The chemotherapeutics currently available to oncologists do not always yield satisfactory outcomes when used in systemic treatments, and patients experience burdensome side effects during their application. In the era of personalized therapies, doctors caring for non-small cell lung cancer (NSCLC) patients have been given a powerful weapon, namely molecularly targeted therapies and immunotherapies. They can be used when genetic variants of the disease qualifying for therapy are diagnosed. These therapies have contributed to the extension of the overall survival time in patients. Nevertheless, effective treatment may be hindered in the case of clonal selection of tumor cells with acquired resistance mutations. The state-of-the-art therapy currently used in NSCLC patients is immunotherapy targeting the immune checkpoints. Although it is effective, some patients have been observed to develop resistance to immunotherapy, but its cause is still unknown. Personalized therapies extend the lifespan and time to cancer progression in patients, but only those with a confirmed marker qualifying for the treatment (gene mutations/rearrangements or PD-L1 expression on tumor cells) can benefit from these therapies. They also cause less burdensome side effects than chemotherapy. The article is focused on compounds that can be used in oncology and produce as few side effects as possible. The search for compounds of natural origin, e.g., plants, bacteria, or fungi, exhibiting anticancer properties seems to be a good solution. This article is a literature review of research on compounds of natural origin that can potentially be used as part of NSCLC therapies.

show abstract

Engineered Microorganisms for Advancing Tumor Therapy

Jia,

Wang,

Lin

et al. 2024

Advanced Materials

View full text Add to dashboard Cite

Engineered microorganisms have attracted significant interest as a unique therapeutic platform in tumor treatment. Compared with conventional cancer treatment strategies, engineering microorganism‐based systems provide various distinct advantages, such as the intrinsic capability in targeting tumors, their inherent immunogenicity, in situ production of antitumor agents, and multiple synergistic functions to fight against tumors. Herein, the design, preparation, and application of the engineered microorganisms for advanced tumor therapy are thoroughly reviewed. This review presents a comprehensive survey of innovative tumor therapeutic strategies based on a series of representative engineered microorganisms, including bacteria, viruses, microalgae, and fungi. Specifically, it offers extensive analyses of the design principles, engineering strategies, and tumor therapeutic mechanisms, as well as the advantages and limitations of different engineered microorganism‐based systems. Finally, the current challenges and future research prospects in this field, which can inspire new ideas for the design of creative tumor therapy paradigms utilizing engineered microorganisms and facilitate their clinical applications, are discussed.

show abstract

Anti-Tumor Secondary Metabolites Originating from Fungi in the South China Sea’s Mangrove Ecosystem

Cited by 3 publications

References 83 publications

A Survey of Recently Discovered Naturally Occurring Organohalogen Compounds

A Survey of Recently Discovered Naturally Occurring Organohalogen Compounds

Natural Bacterial and Fungal Peptides as a Promising Treatment to Defeat Lung Cancer Cells

Engineered Microorganisms for Advancing Tumor Therapy

Contact Info

Product

Resources

About