A quasiclassical trajectory study of final state distributions in collisions of fast H(D) atoms with HF(DF)Detailed results of the converged full-dimensional 6D quantum calculations of the vibrational levels of ͑HF͒ 2 , ͑DF͒ 2 , and HFDF, for total angular momentum Jϭ0, are presented. The ab initio 6D potential energy surface by Quack and Suhm was employed. This study provides a comprehensive description of the bound state properties of the HF dimer and its isotopomers, including their dissociation energies, frequencies of the intermolecular vibrations, tunneling splittings, and extent of wave function delocalization. Quantum number assignment of the calculated eigenstates by plotting different cuts through the wave functions worked rather well for ͑HF͒ 2 , but proved to be much harder for ͑DF͒ 2 and HFDF, indicating stronger vibrational mode mixing in these species. The ground-state tunneling splitting for the HF dimer from our exact 6D calculations, 0.44 cm Ϫ1 , is very close to that from a previous 4D rigid-rotor calculation, 0.48 cm Ϫ1 ͓J. Chem. Phys. 99, 6624 ͑1993͔͒. This is in disagreement with the result of a recent 6D bound state calculation for ͑HF͒ 2 by Necoechea and Truhlar, which gave a ground-state tunneling splitting a factor of 3.7 times larger than the 4D result.
The fabrication of a conducting polyaniline (PANi) matrix based on a template of polystyrene (PS) latex is of interest from an academic and application viewpoint. In this Full Paper, we propose a distinctly novel strategy, which involves swelling followed by diffusion and polymerization at the interface, to fabricate PANi‐coated PS microspheres with uniform size and well‐defined shape, regardless of the type of “naked” PS seed particles. Compared to the widely used conventional synthetic protocol, this method affords much more effective control over the structure and morphology of the resultant composites by simply changing the aniline/PS weight ratio or the rate of addition of the doping agent. In addition, it guarantees the easy and successful production of a hollow nanostructure of a conducing polymer with a uniform, intact shell. The synthesized composites have been characterized using Fourier transform infrared spectroscopy, C, H, and N elemental microanalyses, and transmission electron microscopy. The mechanism governing the formation of the composites is discussed.
A heterocoagulation strategy based on colloidal steric stabilization theory has been developed, through which polystyrene (PS) and silica (SiO(2)) particles without any surface modification or functionalization self-assembled rapidly via solution to afford nanocomposite particles with raspberry-like morphology. The formation mechanism is fully studied on the basis of a thermodynamic analysis. The soluble stabilizer and the solvent quality are the main determining factors, which have a significant influence on this self-assembly process and the silica coverage of resultant composites. The relative size of PS to SiO(2) candidates also has the effect of control on the extent of self-assembly. Furthermore, this strategy can be applied to fabricate a broad range of composite materials, including PS/TiO(2), PS/AgI, as well as PS/PS composites.
Our original findings, showing the effectiveness of active and passive tau immunizations in mouse models, have now been confirmed and extended by many groups, with several clinical trials underway in Alzheimer's disease and progressive supranuclear palsy. Here, we report on a unique and sensitive two-photon imaging approach to concurrently study the dynamics of brain and neuronal uptake and clearance of tau antibodies as well as the acute removal of their pathological target in live animals. This in vivo technique is more sensitive to detect clearance of pathological tau protein than western blot tau analysis of brain tissue. In addition to providing an insight into the mechanisms involved, it allows for an efficient in vivo assessment of the therapeutic potential of tau antibodies, and may be applied to related protein misfolding diseases.
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