The chemical nature of hesperidin and its experimental medical use as a source of vitamin P—a review

Higby, Ralph H.

doi:10.1002/jps.3030301208

Cited by 10 publications

(9 citation statements)

References 30 publications

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“…Hesperidin occurs in greatest concentration in green fruit and its concentration in the fruit increases during storage (Higby, 1941). Its distribution in the epicarp, mesocarp, endocarp and juice of Citrus fruits has been reported (Kawaguchi et al, 1997).…”

Section: Occurrencementioning

confidence: 99%

“…The solubility in water is 1 in 50 (Budavari, 1996). It has a property of forming complex crystals with other similar glucosides, which greatly affects its solubility and other physical properties, making it difficult to obtain in a pure state (Higby, 1941). It can, however, be purified by washing with hot water and extraction with 95% methyl alcohol, followed by crystallization (King and Robertson, 1931).…”

Section: Propertiesmentioning

confidence: 99%

“…Hesperidin, upon alkaline hydrolysis yields phloroglucinol and hesperetenic acid (Higby, 1941). Upon acid hydrolysis, hesperidin produces one mole each of the aglycone hesperetin, D-glucose and L-rhamnose (Asahina et al, 1930).…”

Section: Chemistrymentioning

confidence: 99%

“…Scarborough (1940) used hesperidin in the treatment of purpurea, resulting from the use of arsenicals and in the treatment of syphilis. He reported that hesperidin, as well as hesperetin, were active for increasing capillary resistance Higby (1941) reported the successful use of hesperidin in the clinical treatment of haemorrhagic purpurea and disorders arising from abnormal capillary fragility. This role of hesperidin in increasing capillary resistance has been attributed to its inhibitory effect on the action of hyaluronidase enzyme, which in turn has been known to accentuate capillary permeability and fragility (Beiler and Martin, 1947).…”

Section: Effects On the Vascular Systemmentioning

confidence: 99%

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Chemistry and pharmacology of the citrus bioflavonoid hesperidin

Garg¹,

Garg²,

Zaneveld³

et al. 2001

Phytotherapy Research

735

520

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Hesperidin, a bioflavonoid, is an abundant and inexpensive by-product of Citrus cultivation. A deficiency of this substance in the diet has been linked with abnormal capillary leakiness as well as pain in the extremities causing aches, weakness and night leg cramps. No signs of toxicity have been observed with the normal intake of hesperidin or related compounds. Both hesperidin and its aglycone hesperetin have been reported to possess a wide range of pharmacological properties. This paper reviews various aspects of hesperidin and its related compounds, including their occurrence, physical and chemical properties, analysis, pharmacokinetics, safety and toxicity and the marketed products available. A special emphasis has been laid on the pharmacological properties and medicinal uses of these compounds.

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Section: Occurrencementioning

confidence: 99%

Section: Propertiesmentioning

confidence: 99%

Section: Chemistrymentioning

confidence: 99%

Section: Effects On the Vascular Systemmentioning

confidence: 99%

See 2 more Smart Citations

Chemistry and pharmacology of the citrus bioflavonoid hesperidin

Garg¹,

Garg²,

Zaneveld³

et al. 2001

Phytotherapy Research

735

520

View full text Add to dashboard Cite

show abstract

“…However, in other cases, the initial observations of activity of citrin and other flavonoid fractions could be repeated (12). Although the difficulty to repeat the original work may have been for a variety of reasons, one major problem was that the preparations used by Szent-Györgyi and coworkers were not consistent in composition (45,46,(48)(49)(50). From today's perspective, these reported reproducibility issues could be interpreted as a form of (chemical) residual complexity.…”

Section: Vitamin P Early Evidence For Vitamin P As a Flavonoidmentioning

confidence: 99%

Vitamin P – Do Certain Polyphenolic IMPS Have a Vital Function?

Pauli¹

2020

Preprint

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Abbreviations used: IMPS, invalid/improbable/interfering metabolic panaceas; PAC, proanthocyanidins; OPAC, oligomeric proanthocyanidins. AbstractIn the 1930s, it was discovered that the ability of synthetic Vitamin C to treat scurvy was inferior to plant extracts containing Vitamin C. This observation led to the proposal of Vitamin P (permeability), as an essential phytochemical dietary nutrient. Subsequent attempts to isolate and characterize Vitamin P led to confusing and sometimes irreproducible results. Over the years several flavonoids and coumarins have been identified as having Vitamin P-like activity.Essentially all of these Vitamin P candidates were recently identified as IMPs (Invalid/Improbable/Interfering Metabolic Panaceas) in a NAPRALERT meta analysis. While the historic inability to define a single compound and specific mode of action led to general skepticism about the Vitamin P proposition, the more logical conclusion is that several abundant and metabolically labile plant constituents fill this essential role in human nutrition. This review of 100+ years of multilingual Vitamin P and C literature provides the rationales for this conclusion.

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Dihedral angle study in Hesperidin using NMR Spectroscopy

Jadeja

Kapadiya

Jebaliya

et al. 2017

Magnetic Reson in Chemistry

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Hesperidin is flavonoid molecule found in citrus fruits (Citrus reticulata), especially difficult to extract, classify and characterize. Present work is to study the unresolved relative configuration of Hesperidin through the dihedral angle, coupling constant and different NMR techniques. The Karplus equation and its modifications have been originated from the valence bond theory and associated with dihedral angle and coupling constant. The result data set of calculated dihedral angle can probe significant method to assign the virtual configuration of natural products and also resolved stereochemistry of Hesperidin at C-2 position in. Copyright © 2016 John Wiley & Sons, Ltd.

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The chemical nature of hesperidin and its experimental medical use as a source of vitamin P—a review

Cited by 10 publications

References 30 publications

Chemistry and pharmacology of the citrus bioflavonoid hesperidin

Chemistry and pharmacology of the citrus bioflavonoid hesperidin

Vitamin P – Do Certain Polyphenolic IMPS Have a Vital Function?

Dihedral angle study in Hesperidin using NMR Spectroscopy

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