In current research scenario, an efficient synthesis has been developed for novel tetrazole scaffolds by single step multicomponent reaction. One of the most promising pathways is Ugi multi‐component process for the coupling of four different components in a single reaction step and isolate lead molecule which may serve better life to the society. The syntheses of tetrazoles were undertaken by the Ugi‐Multi Component approach with the condensation of aromatic aldehyde containing active pharmacophore, various aryl amines, isocyanide (cyclohexyl isocyanide) and TMS‐N3 under catalyst free reaction condition at room temperature. The structural conformation were carried out by most acceptable spectroscopic technique i.e. MS, IR, NMR and single crystal study (XRD) and potency of compounds (4a to 4h) were checked at NIH (National Institute of Health) use 60 different cell‐lines with respect to nine cancer panels among which compounds 4a and 4b have been found to be more potent against different cell lines.

Hesperidin is flavonoid molecule found in citrus fruits (Citrus reticulata), especially difficult to extract, classify and characterize. Present work is to study the unresolved relative configuration of Hesperidin through the dihedral angle, coupling constant and different NMR techniques. The Karplus equation and its modifications have been originated from the valence bond theory and associated with dihedral angle and coupling constant. The result data set of calculated dihedral angle can probe significant method to assign the virtual configuration of natural products and also resolved stereochemistry of Hesperidin at C-2 position in. Copyright © 2016 John Wiley & Sons, Ltd.

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Polyethylene glycol-400 (PEG-400) is a recyclable and rapid reaction medium for synthesizing a new series of 4-(3-[substitutedphenyl]-4,5-dihydro-1-phenyl-1H-pyrazol-5-yl)-1H-imidazoles in two-step procedures by condensation of 1H-imidazole-4-carbaldehyde and various acetophenones to form chalcones followed by base-catalyzed cyclization employing phenyl hydrazine in a catalyst-free approach. The way of projected approach provides easy work-up, less reaction time, avoids metal-based and toxic catalysts, high yield, and reduces the use of carcinogenic organic solvents. The synthesized scaffolds have been screened for their anti-microbial and anti-tubercular activity against a set of pathogens.

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