The chemical constituents of <i>Piper kadsura</i> and their cytotoxic and anti-neuroinflammtaory activities

Kim, Ki‐Hyun; Choi, Jung Wook; Choi, Sang Un; Ha, Sang Keun; Kim, Sun Yeou; Park, Hee-Juhn; Lee, Kang Ro

doi:10.3109/14756366.2010.496363

Cited by 28 publications

(14 citation statements)

References 39 publications

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“…e stereochemistry of C-2 was determined as trans by comparison of the 13 us, the structure of compound 5 was assigned to be (2E, 7R, and 11R)-3,7,11,15-tetramethyl-2hexadecen-1-ol (trans-phytol) [19] and isolated from P. bavinum for the first time. is compound was also isolated from Piper kadsura [20]. Trans-phytol was found to possess antinociceptive and antioxidant [21], cytotoxic [22], antischistosomal [23], and arthritis activities [24] and was also found to inhibit neutrophil migration [25].…”

Section: Determination and Elucidation Of Isolated Compoundsmentioning

confidence: 99%

Anti-Inflammatory Compounds from Vietnamese Piper bavinum

Hoang

Nguyen

Doan

et al. 2020

Journal of Chemistry

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This study reports the anti-inflammatory activity-guided fractionation of the aerial part of Piper bavinum C. CD. (Piperaceae) that led to the isolation of eight secondary metabolites (1–8). The chemical structures of 1–8 were established mainly by NMR and mass spectra. Compound 5 was isolated from P. bavinum for the first time. All the isolated compounds were evaluated against LPS-induced NO production in macrophage RAW 264.7 cells in vitro. Among them, compound 4 showed the most potent inhibitory activity against the LPS-induced NO production with an IC50 value of 5.2 μM followed by compound 5 that inhibited NO production with an IC50 value of 13.5 μM. In the protein levels, compound 4 suppressed LPS-induced COX-2 and iNOS expressions in a dose-dependent manner. The results suggested that P. bavinum and its constituents might exert anti-inflammatory effects.

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Section: Determination and Elucidation Of Isolated Compoundsmentioning

confidence: 99%

Anti-Inflammatory Compounds from Vietnamese Piper bavinum

Hoang

Nguyen

Doan

et al. 2020

Journal of Chemistry

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“…Piperolactams 1–3 ( Figure 1 ) are present in several species of Piper , such as P. caninum , P. marginatum , and P. kadsura [ 98 , 138 , 139 ]. This class of compounds is metabolized in vitro and in vivo to a reactive cyclic N -acylnitrenium ion that forms DNA adducts with purine bases, leading to cancer cell death; however, genotoxic and carcinogenic effects in non-tumorigenic cells were observed, as well as shrimp and mice toxicity [ 140 , 141 , 142 ].…”

Section: Literature-related Cytotoxic Compoundsmentioning

confidence: 99%

Peppers: A “Hot” Natural Source for Antitumor Compounds

et al. 2021

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Piper, Capsicum, and Pimenta are the main genera of peppers consumed worldwide. The traditional use of peppers by either ancient civilizations or modern societies has raised interest in their biological applications, including cytotoxic and antiproliferative effects. Cellular responses upon treatment with isolated pepper-derived compounds involve mechanisms of cell death, especially through proapoptotic stimuli in tumorigenic cells. In this review, we highlight naturally occurring secondary metabolites of peppers with cytotoxic effects on cancer cell lines. Available mechanisms of cell death, as well as the development of analogues, are also discussed.

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“…Piplartine,[18] cepharadione A (15), and piperolactams A (16) and B (17) are the active principles. [3132]…”

Section: Piper Plants With Traditional Anticancer Applicationmentioning

confidence: 99%

Anticancer Principles from Medicinal Piper (胡椒 Hú Jiāo) Plants

Wang

Morris‐Natschke²,

Yang

et al. 2014

Journal of Traditional and Complementary Medicine

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The ethnomedical uses of Piper (胡椒 Hú Jiāo) plants as anticancer agents, in vitro cytotoxic activity of both extracts and compounds from Piper plants, and in vivo antitumor activity and mechanism of action of selected compounds are reviewed in the present paper. The genus Piper (Piperaceae) contains approximately 2000 species, of which 10 species have been used in traditional medicines to treat cancer or cancer-like symptoms. Studies have shown that 35 extracts from 24 Piper species and 32 compounds from Piper plants possess cytotoxic activity. Amide alkaloids account for 53% of the major active principles. Among them, piplartine (piperlongumine) shows the most promise, being toxic to dozens of cancer cell lines and having excellent in vivo activity. It is worthwhile to conduct further anticancer studies both in vitro and in vivo on Piper plants and their active principles.

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The chemical constituents of Piper kadsura and their cytotoxic and anti-neuroinflammtaory activities

Cited by 28 publications

References 39 publications

Anti-Inflammatory Compounds from Vietnamese Piper bavinum

Anti-Inflammatory Compounds from Vietnamese Piper bavinum

Peppers: A “Hot” Natural Source for Antitumor Compounds

Anticancer Principles from Medicinal Piper (胡椒 Hú Jiāo) Plants

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