Peppers: A “Hot” Natural Source for Antitumor Compounds

Cunha, Micael Rodrigues; Tavares, Maurício Temotheo; Fernandes, Thais Batista; Parise-Filho, Roberto

doi:10.3390/molecules26061521

Cited by 6 publications

(4 citation statements)

References 212 publications

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“…Cellular responses upon treatment with capsaicin affect mechanisms of cell death, especially through the downregulation of β-catenin which plays an important role in β-catenin-dependent signaling that is a significant event in the development of malignancies ( 65 ). In addition, upregulation of pro-apoptotic genes in other words pro-apoptotic stimuli in tumorigenic cells ( 66 , 67 ). Furthermore, one study stated the anti-proliferative effect of capsicum through the suppression of FBI-1-Mediated NF-κB Pathway that led to breast cancer cell apoptosis ( 68 ).…”

Section: Anticancer Activity Of Spices From the Mediterranean Diet: C...mentioning

confidence: 99%

Anticancer Effect of Spices Used in Mediterranean Diet: Preventive and Therapeutic Potentials

Talib

AlHur²,

Al.Naimat³

et al. 2022

Front. Nutr.

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Cancer is one of the leading causes of death worldwide, with almost 10 million cancer-related deaths worldwide in 2020, so any investigation to prevent or cure this disease is very important. Spices have been studied widely in several countries to treat different diseases. However, studies that summarize the potential anticancer effect of spices used in Mediterranean diet are very limited. This review highlighted chemo-therapeutic and chemo-preventive effect of ginger, pepper, rosemary, turmeric, black cumin and clove. Moreover, the mechanisms of action for each one of them were figured out such as anti-angiogenesis, antioxidant, altering signaling pathways, induction of cell apoptosis, and cell cycle arrest, for several types of cancer. The most widely used spice in Mediterranean diet is black pepper (Piper nigrum L). Ginger and black cumin have the highest anticancer activity by targeting multiple cancer hallmarks. Apoptosis induction is the most common pathway activated by different spices in Mediterranean diet to inhibit cancer. Studies discussed in this review may help researchers to design and test new anticancer diets enriched with selected spices that have high activities.

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Section: Anticancer Activity Of Spices From the Mediterranean Diet: C...mentioning

confidence: 99%

Anticancer Effect of Spices Used in Mediterranean Diet: Preventive and Therapeutic Potentials

Talib

AlHur²,

Al.Naimat³

et al. 2022

Front. Nutr.

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show abstract

“…1 ). Capsaicin exerts analgesic, antioxidant, cardioprotective, anticancer and thermogenic effects, and it can promote weight loss ( 3 ). Some of these effects are mediated by the receptor called ‘transient receptor potential cation channel subfamily V member 1’ (TRPV1), to which capsaicin binds specifically.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological activity of capsaicin: Mechanisms and controversies (Review)

Zhang,

Fan

et al. 2024

Mol Med Rep

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Capsaicin, which is abundant in chili peppers, exerts antioxidative, antitumor, antiulcer and analgesic effects and it has demonstrated potential as a treatment for cardiovascular, gastrointestinal, oncological and dermatological conditions. Unique among natural irritants, capsaicin initially excites neurons but then ‘calms’ them into long-lasting non-responsiveness. Capsaicin can also promote weight loss, making it potentially useful for treating obesity. Several mechanisms have been proposed to explain the therapeutic effects of capsaicin, including antioxidation, analgesia and promotion of apoptosis. Some of the mechanisms are proposed to be mediated by the capsaicin receptor (transient receptor potential cation channel subfamily V member 1), but some are proposed to be independent of that receptor. The clinical usefulness of capsaicin is limited by its short half-life. The present review provided an overview of what is known about the therapeutic effects of capsaicin and the mechanisms involved and certain studies arguing against its clinical use were mentioned.

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“…Alkaloids are among the most representative classes of medicinal phytoprinciples and plant secondary metabolites occurring throughout the plant kingdom serving as tools for research and development of new drugs. [ 1 ] Various studies have reported their anticancer activity including cell proliferation inhibition and apoptosis stimulation in cancer cells. [ 2 ] However, the poor hydrophilicity, bioavailability and membrane penetration properties of capsaicin limit its therapeutic activity.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Capsaicin Encapsulated Polymeric Micelles and Studies of Synergism with Nicotinic Acids as Potential Anticancer Nanomedicines

Shamsheer,

Sunoqrot,

Kasabri

et al. 2023

Journal of Pharmacy and Bioallied Sciences

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Background/Objective/Methods: Capsaicin micelles were prepared by the direct dissolution using the amphiphilic copolymer Pluronic P123 and advanced for substantially novel submicro-nanocytotoxicity. Results: Superior cytotoxicity of capsaicin loaded nanomicelles vs. both the raw capsaicin and reference cisplatin in pancreatic PANC1, breast MCF7, colorectal resistant CACO2, skin A375, lung A549 and prostate PC3 cancer cell lines were delineated. Nicotinic acid (NA) derivative 39 (2-Amino IsoNA) had antiinflammatory potential but consistently lacked antiproliferation in MCF7, PANC1 and CACO2. Besides NA derivatives 8 (5-MethylNA) and 44 (6-AminoNA) exhibited lack of antiinflammation but had comparable antitumorigenesis potency to cisplatin in PANC1 cells. Though capsaicin loaded nanomicelles exerted pronounced antiinflammation (with IC50 value of 510 nM vs. Indomethacin’s) in lipopolysacchride-induced inflammation of RAW247.6 macrophages; they lacked DPPH scavenging propensities. Free capsaicin proved more efficacious vs. its loaded nanocarriers to chemosensitize cytotoxicity of combinations with NAs 1(6-Hexyloxy Nicotinic Acid), 5(6-OctyloxyNA), 8(5-MethylNA), 12(6-Thien-2yl-NA), 13(5,6-DichloroNA) and 44(6-AminoNA) in CACO2, PANC1 and prostate PC3. Conclusion: Capsaicin loaded nanomicelles proved more efficacious vs. free capsaicin to chemo-sensitize antiproliferation of cotreatments with NA derivatives, 1, 5, 8, 12, 13 and 44 (in skin A375), 1, 5, 8 and 12 (in breast MCF7), and 1, 5, 12 and 44 (in lung A549).

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Peppers: A “Hot” Natural Source for Antitumor Compounds

Cited by 6 publications

References 212 publications

Anticancer Effect of Spices Used in Mediterranean Diet: Preventive and Therapeutic Potentials

Anticancer Effect of Spices Used in Mediterranean Diet: Preventive and Therapeutic Potentials

Pharmacological activity of capsaicin: Mechanisms and controversies (Review)

Preparation and Characterization of Capsaicin Encapsulated Polymeric Micelles and Studies of Synergism with Nicotinic Acids as Potential Anticancer Nanomedicines

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