The Characteristics of the Transitional Zone in Prostate Growth With Age

Cao, Nailong; Lu, Qijie; Si, Jiemin; Wang, Xiaohu; Ni, Jianshu; Chen, Lei; Gu, Baojun; Hu, Bing

doi:10.1016/j.urology.2017.03.010

Cited by 13 publications

(18 citation statements)

References 26 publications

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“…To calibrate and test our mechanically coupled mathematical model, we also studied the deformation of the prostate under the development of BPH and PCa. Overall, our results in terms of displacements and deformational features for BPH and PCa agree with previous studies in the medical literature (1,42,50). BPH produced the volumetric expansion of the prostate, with slightly higher displacements craniocaudally and anteroposteriorly at the basal level.…”

Section: Discussionsupporting

confidence: 91%

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Computer simulations suggest that prostate enlargement due to benign prostatic hyperplasia mechanically impedes prostate cancer growth

Lorenzo

Hughes

Dominguez-Frojan

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

105

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Prostate cancer and benign prostatic hyperplasia are common genitourinary diseases in aging men. Both pathologies may coexist and share numerous similarities, which have suggested several connections or some interplay between them. However, solid evidence confirming their existence is lacking. Recent studies on extensive series of prostatectomy specimens have shown that tumors originating in larger prostates present favorable pathological features. Hence, large prostates may exert a protective effect against prostate cancer. In this work, we propose a mechanical explanation for this phenomenon. The mechanical stress fields that originate as tumors enlarge have been shown to slow down their dynamics. Benign prostatic hyperplasia contributes to these mechanical stress fields, hence further restraining prostate cancer growth. We derived a tissuescale, patient-specific mechanically coupled mathematical model to qualitatively investigate the mechanical interaction of prostate cancer and benign prostatic hyperplasia. This model was calibrated by studying the deformation caused by each disease independently. Our simulations show that a history of benign prostatic hyperplasia creates mechanical stress fields in the prostate that impede prostatic tumor growth and limit its invasiveness. The technology presented herein may assist physicians in the clinical management of benign prostate hyperplasia and prostate cancer by predicting pathological outcomes on a tissue-scale, patient-specific basis.prostate cancer | benign prostatic hyperplasia | mathematical oncology | patient-specific | isogeometric analysis

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Section: Discussionsupporting

confidence: 91%

“…The analysis of BPH and PCa deformation and the computation of the stress fields σ 0 rendered g = 2.34 cc/y, = 2.78, and kw = 0.23 kPa/mm. These values for g and reasonably agree with previous observations in the literature for our patient characteristics (1,3,(50)(51)(52)(53).…”

Section: Methodssupporting

confidence: 93%

Computer simulations suggest that prostate enlargement due to benign prostatic hyperplasia mechanically impedes prostate cancer growth

Lorenzo

Hughes

Dominguez-Frojan

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

105

View full text Add to dashboard Cite

show abstract

“…Age is considered to be a risk factor associated with prostate volume. Evidence of prostate development with increasing age was established in a community-based cohort [11,12,14,15] and in urological outpatients [13]. It is interesting that some studies have shown that the prostate growth rate gradually decreases after the age of 70.…”

Section: Discussionmentioning

confidence: 98%

“…Williams and his colleagues described that the prostate growth rate peaked at 4.15 ± 4.98 mL/year between 56 and 65 years old, and then declined rapidly [ 14 ]. In two other studies from China, Shi-Jun Zhang et al [ 15 ] found that the prostate had a relatively stable growth rate in men aged 40–70, while Nailong Cao’s study [ 13 ] revealed that the fastest period of prostate growth was between 50 and 69 years old. Our results are in line with these studies.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have confirmed that prostate volume increases with age [ 11 , 12 ]. Moreover, in recent years, some studies have pointed out that the prostate growth rate before the age of 70 is significantly faster and more stable than after the age of 70 [ 13 – 15 ]. Although both diabetes and age are associated with prostate volume growth, it is not clear whether there is an effect or synergistic amplification between the two.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between glucose homeostasis status and prostate size in aging Chinese males with benign prostatic hyperplasia

Ding

Cao

et al. 2020

World J Urol

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Purpose Increasing evidence shows that many metabolic factors are involved in the progression of benign prostatic hyperplasia (BPH). We aimed to assess the relationship between the status of glucose homeostasis and prostate size in aging Chinese males undergoing transurethral resection of the prostate (TURP) for BPH. Methods A total of 1006 medical records of BPH patients undergoing TURP were reviewed. Prostate size was measured by transrectal ultrasound. Annual total prostate (TP) and transitional zone (TZ) growth rates were calculated. According to the American Diabetes Association criteria, the patients were categorized as normoglycemic, prediabetic, or diabetic. Levels of glucose homeostasis and other variables were considered independent variables in an effort to evaluate any potential correlations using non-adjusted and multivariate-adjusted regression models. Results A total of 659 individuals were included in the study. BPH patients < 70 years old and ≥ 70 years old in the normoglycemic group had a stable prostate growth rate. The change in prostate size in those younger than 70 years, however, was faster in the prediabetic and diabetic group. Further analysis revealed that abnormal glucose homeostasis was positively correlated with prostate size. In those younger than 70 years, compared with the normal glucose group, the adjusted odds ratio (OR) for TP and TZ enlargement in the prediabetic group was 2.27 (95%CI 1.29-4.00) and 3.19 (95%CI 1.78-5.72), respectively, and the adjusted ORs were 4.74 (95%CI 2.18-10.30) and 6.16 (95%CI 2.70-14.06), respectively, for men with diabetes. However there was no significant difference among men aged ≥ 70 years. Conclusions Among patients undergoing TURP, the prostate volume and growth rate were affected by different status of glucose homeostasis. Hyperglycemia may play an important role in prostate growth. Keywords Benign prostate hyperplasia • Glucose homeostasis • Prediabetes • Prostate size Y. Wu and Y. Ding equally contributed to this study.

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Patient-specific forecasting of postradiotherapy prostate-specific antigen kinetics enables early prediction of biochemical relapse

Lorenzo¹,

Muzio²,

Deantoni³

et al. 2022

iScience

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The Characteristics of the Transitional Zone in Prostate Growth With Age

Cited by 13 publications

References 26 publications

Computer simulations suggest that prostate enlargement due to benign prostatic hyperplasia mechanically impedes prostate cancer growth

Computer simulations suggest that prostate enlargement due to benign prostatic hyperplasia mechanically impedes prostate cancer growth

The relationship between glucose homeostasis status and prostate size in aging Chinese males with benign prostatic hyperplasia

Patient-specific forecasting of postradiotherapy prostate-specific antigen kinetics enables early prediction of biochemical relapse

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