The Change in Concentration of Certain Constituents of the Medium During Growth of the Strain Hela Cells1

The relation between glucose utilization, lactic acid production and utilization and the growth cycle of L strain fibroblasts

“…It is therefore possible that these acids are depressing the pH. However Krestfall [24] and Jones [14] found that these acids, such as pyruvic or keto glutaric did not accumulate in the medium in appreciable quantities. Lactate again began to accumulate in the medium as the cultures neared the plateau of growth.…”

Factors affecting the lactate dehydrogenase isoenzyme pattern of cultured kidney-cortex cells

“…A relationship has been found between glycolysis and cell division (Kitos & Waymouth, 1964;Cristofalo & Kritchevsky, 1965;Westfall, Peppers & Earle, 1955). During different phases of growth, changes occur in the pattern of carbohydrate metabolism of monolayer cultures (Paul, 1965, p. 51).…”

Glutamic dehydrogenase in the developing chick embryo

“…The presence of minute amounts of GDH in tissues of the chick embryo does not indicate the extent to which the enzyme is being used for glutamic acid oxidation or synthesis. Both a-oxoglutaric acid (Westfall, Peppers & Earle, 1955) and glutamic acid (Rupe & Farmer, 1955) are known to be present in 9-day-old chick embryos and their extra-embryonic tissue. Rupe & Farmer (1955) consider that the large reserves of free glutamic acid in the egg yolk and white are sufficient to satisfy the requirements of the developing embryo and, as these authors point out, the amount ofglutamic acid that might be synthesized by the embryo is necessarily small.…”