Glutamic dehydrogenase in the developing chick embryo

“…A general increase in level of glutamate dehydrogenase activity during nervous tissue development has been described in a number of forms (Bayer and McMurray, 1967;Jolley and Labby, 1960;Kuhlman and Lowry, 1956;Solomon, 1957;Wang, 1968). A general increase in level of glutamate dehydrogenase activity during nervous tissue development has been described in a number of forms (Bayer and McMurray, 1967;Jolley and Labby, 1960;Kuhlman and Lowry, 1956;Solomon, 1957;Wang, 1968).…”

Section: Discussionmentioning

confidence: 99%

Activity of Glutamate and Malate Dehydrogenases and The Malic Nzyme' During The Development of The Chick Spinal Cord

Burt

1971

International Journal of Neuroscience

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The specific activities of glutamate dehydrogenase (E.C. I .4.1.2.), malate dehydrogenase. (E.C. 1 .I. 1.37), and the 'malic' enzyme (E.C. 1.1 .I 40) were measured in the brachial spinal cord of chick embryos ranging in development from 3.0 to 21 days' incubation. The specific activity for both dehydrogenases increased sharply from 10.5 to 16 days of incubation. These findings, when compared with other enzymatic and morphological studies suggest that increased TCA-cycle and amino acid metabolism are coincident with increased glycolysis during the period of morphological and functional maturation. The ontogenetic pattern of the 'malic' enzyme was characterized by a transient peak of activity at 7 days and a subsequent increase in activity from 10 to I5 days' incubation. A comparison of this data with that of other enzymes of carbohydrate metabolism led t o the suggestion that the 'malic' enzyme may provide a source of NADPH for myelinization and may play a role in the regulation of glucose metabolism through the synthesis of pyruvate. the development of nervous tissue (Kuhlman and Lowry, 1956;Lehrer et a/., 1970a, b;Robins and Lowe, 1961;Solomon, 1958;Wang, 1968). The 28 3 Int J Neurosci Downloaded from informahealthcare.com by Chinese University of Hong Kong on 02/05/15 For personal use only. Int J Neurosci Downloaded from informahealthcare.com by Chinese University of Hong Kong on 02/05/15 For personal use only.

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“…2c). So far the only mention of glutamic dehydrogenase activity in embryos has been that of Solomon (1957), who found it first in the yolk sac and then later accumulating in the liver of the chick embryo, where it reached a peak of demonstrable activity at 16 days. Evidently the embryonic liver takes on quite early in its history some of the biochemical functions characteristic of adult liver.…”

Section: (B) Glutamzc Dehydrogenasementioning

confidence: 99%

The Roles of Amino Acids in Animal Embryogenesis

Deuchar

1962

Biological Reviews

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Glutamic dehydrogenase in the developing chick embryo

Cited by 32 publications

References 18 publications

Ammonia Detoxication in Liver from Humans.

Ammonia Detoxication in Liver from Humans.

Activity of Glutamate and Malate Dehydrogenases and The Malic Nzyme' During The Development of The Chick Spinal Cord

The Roles of Amino Acids in Animal Embryogenesis

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