“…Despite significant advancement in cancer treatment, there are still some limitations in cancer chemotherapy including the high cost of treatment (Penny & Wallace, ), multidrug resistance (Chi et al, ), and cytotoxicity to healthy tissue (Hersberger, Boeni, & Arnet, ). Moreover, most of the chemotherapeutic drugs aim to inhibit cell proliferation, whereas invasion and metastasis inhibition is also necessary (Penny & Wallace, ). Natural compounds are tried as a single agent or combination therapy to overcome these limitations.…”