The challenge of improving pterostilbene (PTS) solubility for solid and semi-solid dosage forms: The obtention of binary and ternary systems

Waszczuk, Mairique; Bianchi, S.; Pittol, Vanessa; Martiny, Simony; Delagustin, Maria Gabriele; Meirelles, Gabriela de Carvalho; Raabe, Victorya Benes; Barbosa, Fábio De Souza; Lacerda, Denise dos Santos; Araújo, Alex Sander; Bassani, V. L.

doi:10.1016/j.ijpharm.2023.122736

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…After 1 h, 74.03 ± 4.47% of PTS was released from the complex PTS-TIC (Figure 3). In another study, PTS release was reported to be 72% and 87% in 15 min for a binary (PTS: βCD) and a ternary (PTS: βCD: HPMC) inclusion complex, respectively [57]. Moreover, the co-precipitation product of PTS significantly enhanced PTS dissolution in another study.…”

Section: Dissolution Studymentioning

confidence: 89%

Microwave-Assisted Formation of Ternary Inclusion Complex of Pterostilbene

Bin Jardan,

Ahad,

Raish

et al. 2023

Pharmaceuticals

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Pterostilbene (PTS) is a naturally occurring phytoalexin. PTS displays limited water solubility, which consequently results in its diminished oral bioavailability. Therefore, a ternary inclusion complex (TIC) of PTS with β-cyclodextrin (βCD) in the presence of ternary substance Pluronic® F-127 (PLF) was prepared using microwave technology. The PTS-TIC was characterized by dissolution performance. Further, the prepared TIC was characterized by DSC, FTIR, NMR, XRD, and SEM analysis. Additionally, the antioxidant activity of PTS and PTS-TIC was also evaluated. Phase-solubility studies revealed that PTS’s solubility in water was increased by 6.72 times when βCD/PLF was present. In comparison with PTS, prepared PTS-TIC produced a considerable improvement in PTS release. After 1 h, 74.03 ± 4.47% of PTS was released from PTS-TIC. Outcomes of DSC, FTIR, NMR, XRD, and SEM analysis revealed that the PTS was enclosed in the βCD cavity. In terms of antioxidant properties, the PTS-TIC formulation demonstrated superior activity compared to PTS, possibly attributed to the improved solubility of PTS resulting from the formation of TIC using microwave technology. It was concluded that microwave technology proved to be an extremely beneficial means of interacting PTS with βCD. In addition to increasing the solubility of PTS, the findings are also expected to improve its bioavailability by increasing its solubility. As a result, this study could provide insight into potential methods for enhancing the solubility of polyphenolic substances like PTS.

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Section: Dissolution Studymentioning

confidence: 89%

Microwave-Assisted Formation of Ternary Inclusion Complex of Pterostilbene

Bin Jardan,

Ahad,

Raish

et al. 2023

Pharmaceuticals

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“…This method has the characteristics of high accuracy and high sensitivity, which are especially suitable for separation of mixtures. Becker, L. et al used MALDI-MS imaging to simultaneously localize resveratrol, pterostilbene, and glucoside on grape leaves [70]. Because MALDI is a soft ionization technique, molecular information can be retained and there is no need to label the compounds of interest for detection, as with fluorescence microscopy.…”

Section: Detection and Analysis Methods Mass Spectrometry (Ms)mentioning

confidence: 99%

“…HPLC + MSn Distinguishes anthocyanins from pro-anthocyanidins [64] Pterostilbene MALDI mass spectrometry Simultaneously localizes resveratrol, pterostilbene, and glucoside on grape leaves [70] RP-HPLC…”

Section: Anthocyaninmentioning

confidence: 99%

The Research Progress of Extraction, Purification and Analysis Methods of Phenolic Compounds from Blueberry: A Comprehensive Review

Bai

Zhou

et al. 2023

Molecules

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Blueberry is the source of a variety of bioactive substances, including phenolic compounds, such as anthocyanins, pterostilbene, phenolic acids, etc. Several studies have revealed that polyphenols in blueberry have important bioactivities in maintaining health, such as antioxidant and anti-tumor activities, immune regulation, the prevention of chronic diseases, etc. Therefore, these phenolic compounds in blueberries have been widely used in the field of healthcare, and the extraction, isolation, and purification of phenolic compounds are the prerequisites for their utilization. It is imperative to systematically review the research progress and prospects of phenolic compounds present in blueberries. Herein, the latest progress in the extraction, purification, and analysis of phenolic compounds from blueberries is reviewed, which can in turn provide a foundation for further research and usage of blueberries.

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