The CD226 gene in susceptibility of rheumatoid arthritis in the Chinese Han population

Abstract

Recent case-control studies have identified some loci that are associated with rheumatoid arthritis (RA). Among these, a single nucleotide polymorphism (SNP), Gly307Ser (rs763361), in the CD226 gene was first discovered to confer the risk of RA in populations with European and Colombian ancestry. Because the effect of genetic factors varies in different races, the association between RA and CD226 is yet to be evaluated in other non-European populations. Here, we report the significant association between CD226 and RA in a Chinese population of 423 randomly enrolled individuals. The statistical results show that the rs763361 SNP in the CD226 gene is significantly associated with RA in the Chinese population group (P (obs) = 0.005, odds ratio = 1.52). After adjusting for sex and age using multivariate logistics regression analysis, the association is still positive (P (adj) = 0.029, odds ratio = 1.45). Meta-analysis confirms the association between rs763361 and RA (overall P < 0.001, overall odds ratio = 1.12). The test of odds ratio heterogeneity also suggests that the rs763361 SNP confers the same risk of RA in both the Chinese and the Colombian populations, and indicates that rs763361 may play a more important role in non-European populations compared with the European population (P = 0.031). These results demonstrate a genetic association between the CD226 gene and RA in a Chinese Han population with a potentially greater genetic effect than in the European population.

Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

“…Four articles were excluded because 2 were review articles, 1 contained duplicate data, and 1 had no data concerning the polymorphisms. Thus, 19 studies met our inclusion criteria [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. They consisted of 8 studies on the CTLA-4 polymorphism with 2093 patients and 2480 controls, 5 on the CD226 polymorphism with 2278 patients and 1940 controls, 6 on the FAS polymorphism with 546 patients and 618 controls, and 3 on the FASL polymorphism with 321 patients and 307 controls (Fig.…”

“…While some studies have found that CTLA-4 rs5742909, CD226 rs763361, FAS-670 rs1800682, and FASL rs763110 polymorphisms are associated with RA, other studies have reported no such association [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. To overcome the limitations of individual studies, resolve inconsistencies, and reduce the likelihood that random errors are responsible for false positive or false negative associations [32][33][34], we performed a meta-analysis to determine whether these polymorphisms are associated with RA susceptibility.…”

Association between the CD226 rs763361 polymorphism and susceptibility to autoimmune diseases: a meta-analysis

“…Many genes have been studied in this context, and the CD226 gene is one such gene in the context of autoimmune diseases. [9][10][11][12][13][14][15][16][17][18] Furthermore, accumulating evidence suggests the presence of common genetic factors that predispose to autoimmunity. The finding that the CD226 gene is associated with a subgroup of autoimmune diseases provides support for the notion that susceptibility to many autoimmune diseases may have some common susceptibility alleles or pathways.…”

“…[8][9][10][11][12][13][14][15][16][17][18][35][36][37] Four reports were excluded due to a lack of genotype data, 8,[35][36][37] and thus, 10 reports met the inclusion criteria. [9][10][11][12][13][14][15][16][17][18] In addition, one of these reports contained data on two different groups, 13 and another on seven different groups, 9 and we analysed these studies independently. Therefore, a total of 17 separate studies were considered in the meta-analysis, which in total, contained 8900 patients and 10,295 controls, and seven European, five Asian and five South American sample populations (Table 1).…”

“…9 Studies have shown that the CD226 rs763361 polymorphism is associated with several autoimmune diseases, but on the other hand, other reports found no such associations. [9][10][11][12][13][14][15][16][17][18] These disparities are probably caused by small sample sizes, low statistical power, and/or clinical heterogeneity, and therefore, to overcome the limitations of individual studies, resolve inconsistencies, and reduce the likelihood that random errors are responsible for false-positive or false-negative associations, we turned to meta-analysis. [19][20][21] The aim of the present study was to determine using meta-analysis whether the CD226 rs763361 polymorphism confers susceptibility to autoimmune diseases, such as, systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA) and type 1 diabetes (T1D).…”