Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

Lee, Young Ho; Bae, Sang Cheol; Song, Gwan Gyu

doi:10.1016/j.humimm.2015.01.023

Cited by 20 publications

(15 citation statements)

References 43 publications

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“…However, to date, there have been few reports regarding the specific pathogenesis of viral myocarditis. The clinical manifestations of viral myocarditis usually occur after acute viral infection (Cohen et al, 2014;Lee et al, 2015;Zhong et al, 2015). The main manifestation of viral myocarditis during the first 7 days of viral infection is myocardial infiltration by NK cells and macrophages.…”

Section: Discussionmentioning

confidence: 99%

Fas-FasL expression and myocardial cell apoptosis in patients with viral myocarditis

Huang

Wang

et al. 2016

Genet. Mol. Res.

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Section: Discussionmentioning

confidence: 99%

Fas-FasL expression and myocardial cell apoptosis in patients with viral myocarditis

Huang

Wang

et al. 2016

Genet. Mol. Res.

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“…However, no meta-analysis has investigated the association between IVDD or OA and Fas/FasL polymorphism up to now. Two meta-analyses, Zhu et al (published in 2016) [ 31 ] and Lee et al [ 33 ] have analyzed the association between RA and Fas/FasL recently. For Zhu et al(published in 2016) [ 31 ] it only included and analyzed Chinese patients for Fas (rs2234767) site.…”

Section: Introductionmentioning

confidence: 99%

“…For Zhu et al(published in 2016) [ 31 ] it only included and analyzed Chinese patients for Fas (rs2234767) site. For Lee et al [ 33 ], it only analyzed Fas polymorphism and there are some mistakes in data extractions for some studies included, such as, Huang et al [ 26 ], Lee et al [ 28 ] and Coakley et al [ 25 ]…”

Section: Introductionmentioning

confidence: 99%

“…So we performed a comprehensive meta-analysis containing three MSDD (OA, RA and IVDD) and enrolling all races of populations besides Chinese. Also we corrected the mistakes of the previous meta-analysis, Lee et al [ 33 ] and added a new study, Zhu et al (published in 2016) [ 31 ] when analyzing. This meta-analysis is designed to explore the association of MSDD (OA, RA and IVDD) with Fas/FasL polymorphism, which could assist to forecast the susceptibility of MSDD for specific individuals or conduct the clinical treatment for ‘high-risk’ individuals.…”

Section: Introductionmentioning

confidence: 99%

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Association between Fas/FasL gene polymorphism and musculoskeletal degenerative diseases: a meta-analysis

Huang

Jian

Deng

et al. 2018

BMC Musculoskelet Disord

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BackgroundIt was reported that Fas (rs1800682, rs2234767) and FasL (rs5030772, rs763110) gene polymorphism might be related to the risk of musculoskeletal degenerative diseases (MSDD), such as osteoarthritis (OA), intervertebral disc degeneration (IVDD) and rheumatoid arthritis (RA). However, data from different studies was inconsistent. Here we aim to elaborately summarize and explore the association between the Fas (rs1800682, rs2234767) and FasL (rs5030772, rs763110) and MSDD.MethodsLiteratures were selected from PubMed, Web of Science, Embase, Scopus and Medline in English and VIP, SinoMed, Wanfang and the China National Knowledge Infrastructure (CNKI) in Chinese up to August 21, 2017. All the researches included are case-control studies about human. We calculated the pooled odds ratios (ORs) with 95% confidence intervals (95% CI) to evaluate the strengths of the associations of Fas (rs1800682, rs2234767) and FasL (rs5030772, rs763110) polymorphisms with MSDD risk.ResultsEleven eligible studies for rs1800682 with 1930 cases and 1720 controls, 6 eligible studies for rs2234767 with 1794 cases and 1909 controls, 3 eligible studies for rs5030772 with 367 cases and 313 controls and 8 eligible studies for rs763110 with 2010 cases and 2105 controls were included in this analysis. The results showed that the G allele of Fas (rs1800682) is associated with an increased risk of IVDD in homozygote and recessive models. The G allele of Fas (rs2234767) is linked to a decreased risk of RA but an enhanced risk of OA in allele and recessive models. In addition, the T allele of FasL (rs763110) is correlated with a reduced risk of IVDD in all of models. However, no relationship was found between FasL (rs5030772) and these three types of MSDD in any models.ConclusionsFas (rs1800682) and FasL (rs763110) polymorphism were associated with the risk of IVDD and Fas (rs2234767) was correlated to the susceptibility of OA and RA. Fas (rs1800682) and Fas (rs2234767) are more likely to be associated with MSDD for Chinese people. FasL (rs763110) is related to the progression of MSDD for both Caucasoid and Chinese race groups. But FasL (rs5030772) might not be associated with any types of MSDD or any race groups statistically.Electronic supplementary materialThe online version of this article (10.1186/s12891-018-2057-z) contains supplementary material, which is available to authorized users.

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“…Such variants are by definition known as primary causal risk factors. In this framework, it has been documented that common variants of PTPN22 (1-7), CTLA-4 (8)(9)(10)(11)(12), STAT4 (13)(14)(15)(16), TRAF1/C5 (17,18) and CD40 (19)(20)(21)(22) are associated with different autoimmune disorders.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the genetic overlap between rheumatoid arthritis and psoriatic arthritis in a Greek population

Myrthianou

Zervou

Budu-Aggrey

et al. 2016

Scandinavian Journal of Rheumatology

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Genetic overlap between PsA and RA was detected for the rs34536443 SNP of the TYK2 gene within a Greek population. An association of STAT4 (rs10181656) with PsA was confirmed whereas CD226 (rs763361) was associated with PsA but not with RA, in contrast to previous reports. The different findings of this study compared to previous ones highlights the importance of comparative studies that include various ethnic or racial populations.

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Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

Cited by 20 publications

References 43 publications

Fas-FasL expression and myocardial cell apoptosis in patients with viral myocarditis

Fas-FasL expression and myocardial cell apoptosis in patients with viral myocarditis

Association between Fas/FasL gene polymorphism and musculoskeletal degenerative diseases: a meta-analysis

Investigation of the genetic overlap between rheumatoid arthritis and psoriatic arthritis in a Greek population

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