Epidemiology and genetics of granulomatosis with polyangiitis

Banerjee, Pratibha; Jain, Arushi; Kumar, Uma; Senapati, Sabyasachi

doi:10.1007/s00296-021-05011-1

Cited by 15 publications

(19 citation statements)

References 120 publications

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“…2 ). Cases with this piece of information were slightly younger than cases without it (11 [ 8 – 18 ] months of age vs 14 [ 9 – 21 ] months of age, P < 0.05). The male-to-female ratio was similar in the two groups (309 boys and 138 girls, respectively, 40 boys and 17 girls).…”

Section: Resultsmentioning

confidence: 94%

“…The temporal relationship between the infectious precursor and the onset of the skin eruption was not detailed in 65 cases (47 boys and 18 girls, 11 [ 8 – 18 ] months of age). This parameter was reported in the remaining 336 cases (230 boys and 106 girls, 11 [ 8 – 17 ] months of age).…”

Section: Resultsmentioning

confidence: 99%

“…In 37 cases (24 males and 13 females, 12 [ 7 – 18 ] months of age), the skin eruptions were preceded by one or more active immunizations (Table 4 ). The temporal relationship between the vaccination and the onset of this vasculitis was not described in 10 cases (8 boys and 2 girls, 17 [ 8 – 20 ] months of age).…”

Section: Resultsmentioning

confidence: 99%

“…The temporal relationship between the vaccination and the onset of this vasculitis was not described in 10 cases (8 boys and 2 girls, 17 [ 8 – 20 ] months of age). The latency time was 7 [ 3 – 13 ] days in the remaining 27 cases (16 boys and 11 girls, 12 [ 7 – 18 ] months of age).…”

Section: Resultsmentioning

confidence: 99%

“…The latency time was 7 [ 3 – 13 ] days in the remaining 27 cases (16 boys and 11 girls, 12 [ 7 – 18 ] months of age).…”

Section: Resultsmentioning

confidence: 99%

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Infections or Vaccines Associated with Finkelstein-Seidlmayer Vasculitis: Systematic Review

Bronz

Betti

Rinoldi

et al. 2022

Clinic Rev Allerg Immunol

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Finkelstein-Seidlmayer vasculitis, also referred to as acute hemorrhagic edema of young children, is a rare small-vessel leukocytoclastic vasculitis. This condition is skin-limited, mainly affects infants up to 2 years of age and spontaneously remits. It has been suggested that an infection or a vaccine precede (by ≤ 14 days) this vasculitis. To better understand the interplay between infections or vaccines and Finkelstein-Seidlmayer vasculitis, we utilized the data contained in the Acute Hemorrhagic Edema BIbliographic Database AHEBID. The database, initiated in 2019, is being regularly updated, encompasses the entire original literature on Finkelstein-Seidlmayer vasculitis published after the original description and is attainable on request. The possible existence of an infectious or a vaccine precursor was addressed in 447 cases. Most cases were preceded by an infection (N = 384; 86%), by a vaccination (N = 20; 4.4%), or both an infection and a vaccination (N = 17; 3.8%). No precursor was reported in the remaining cases (N = 26; 5.8%). Two distinct infections preceded the onset of the vasculitis in 11 of the 381 cases with infection-associated Finkelstein-Seidlmayer vasculitis. The following infectious precursors were reported: upper respiratory tract infection (N = 292); acute gastroenteritis (N = 40); a benign febrile infection (N = 36); lower respiratory tract infection (N = 22); further infections (N = 8). The temporal relationship between the infectious precursor and the onset of the skin eruption was detailed in 336 cases: 54 cases developed before resolution and 282 after resolution of the infection. In conclusion, most cases of Finkelstein-Seidlmayer vasculitis are preceded by an infection. In a minority of cases, this skin vasculitis develops before resolution of the infection. In most cases, however, this vasculitis develops after resolution of the infection. More rarely, this vasculitis is preceded by a vaccination.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The latency time was 7 [ 3 – 13 ] days in the remaining 27 cases (16 boys and 11 girls, 12 [ 7 – 18 ] months of age).…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Infections or Vaccines Associated with Finkelstein-Seidlmayer Vasculitis: Systematic Review

Bronz

Betti

Rinoldi

et al. 2022

Clinic Rev Allerg Immunol

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Quest in Managing Refractory Mastoiditis—A Case of Granulomatosis With Polyangiitis

Tan

Hashim

Abdullah

2022

JAMA Otolaryngol Head Neck Surg

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Granulomatous polyangiitis misdiagnosed as hematogenous lung abscess: A case report

Yang

Chang

2022

Clinical Case Reports

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Granuloma polyangiitis (GPA) is a necrotizing granulomatous inflammation, which is a systemic autoimmune disease that mainly affects the upper respiratory tract, lungs, and kidneys. Clinically, the clinical manifestations of GPA vary greatly, and it is extremely easy to be misdiagnosed. We report a 60‐year‐old man with granulomatous polyangiitis with dysuria and parotid gland enlargement as the first symptom. As the condition worsened, he gradually developed symptoms in multiple systems such as persistent high fever, nosebleeds, hemoptysis, skin rash, and multiple cavities in the lungs. Due to high fever, hemoptysis, and the gradual expansion of lung cavities, the suspected hematogenous lung abscess was not well controlled and transferred to the respiratory department. The manifestation of involvement was finally confirmed by skin biopsy. Biopsy was performed on the skin of the lower extremities with a dark red rash with multiple microprojections. Pathology indicated neutrophilic infiltration and necrosis of small vessel walls, and granuloma formation. Blood anti‐protease 3 antibody (PR3) was positive Monotherapy with prednisone. Body temperature gradually returned to normal; hemoptysis and nasal bleeding disappeared; parotid gland enlargement and dysuria relieved, and lung cavities gradually reduced. When anti‐infective treatment is ineffective, we should consider the presence of some non‐infectious diseases, especially when multiple systems are involved; biopsy should be performed as soon as possible. Granulomatous polyangiitis has various manifestations. Parotid glands and prostate may also be the first organs involved, not limited to common targets such as the respiratory tract and kidneys.

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Epidemiology and genetics of granulomatosis with polyangiitis

Cited by 15 publications

References 120 publications

Infections or Vaccines Associated with Finkelstein-Seidlmayer Vasculitis: Systematic Review

Infections or Vaccines Associated with Finkelstein-Seidlmayer Vasculitis: Systematic Review

Quest in Managing Refractory Mastoiditis—A Case of Granulomatosis With Polyangiitis

Granulomatous polyangiitis misdiagnosed as hematogenous lung abscess: A case report

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