The causes of male infertility in 504 consecutive Nigerian patients

Osegbe, D N; Amaku, E O

doi:10.1007/bf02083505

Cited by 27 publications

(18 citation statements)

References 40 publications

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“…This study showed that 36 percent of the women knew that ART could be applied for treatment of male infertility. This figure is low considering that male infertility due to oligospermia is the second common cause of infertility in Africa after tubo-peritoneal factor [2,3,4]. Knowledge on the use of donor gamete and zygote and their preservation was low in this study.…”

Section: Discussionmentioning

confidence: 57%

“…Female infertility was reported to account for about 55% of infertility cases, male factor for about 30% to 40% of cases and unexplained infertility accounted for the remaining 5 to 15 percent [2,3,4]. In most African setting, parenthood is culturally mandatory and childlessness is socially unacceptable; this is because children are highly desired addition to the family and the society [5].…”

Section: Introductionmentioning

confidence: 99%

“…Sexually transmitted infections mainly from gonorrhoea and Chlamydia, and pregnancy related infections during or after abortion and childbirth are the main culprit. In Africa, infections resulting in tubo-peritoneal factor and oligo-azoospermia are the two leading causes of infertility [2,3,4]. The place of tubal surgery versus IVF (in vitro fertilization) in the treatment of tubal infertility showed that patients are optimally treated with IVF [7].…”

Section: Introductionmentioning

confidence: 99%

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Awareness and perception of assisted reproductive technology practice amongst women with infertility in Northern Nigeria

Adesiyun¹,

Ameh²,

Solomon³

et al. 2011

OJOG

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Background: Involuntary infertility is a tragedy in most African setting. This is due to premium placed on fertility as a result of roles children fulfill in the family and the society. Aetiologic factors of infertility in sub-Saharan Africa are mostly infection related and they are mainly associated with poor treatment outcome to conventional non assisted conception technique. Objective: To evaluate the level of awareness and perception of assisted conception treatment among women attending fertility clinic. Methods: A descriptive cross-sectional study. Results: One hundred and ninety six women attending fertility clinic were interviewed. Mean age was 34.8 years and mean duration of infertility of 4.1 years. Of the 196 infertile women interviewed, 150 (76.5%) have heard of Assisted Reproductive Technology treatment. Sources of information were mainly family relation (46%) and friends (28.7%). Knowledge on some of Assisted Reproductive Technology practices showed that 50.7% were aware that the treatment could fail, 36.8% knew it could be applied for male infertility treatment, 9.3% and 18.7% respectively are aware that donor oocyte and sperm could be used for treatment. Perception on babies conceived from assisted conception treatment revealed that 52% of patients interviewed could not comment if they are normal and natural babies. Majority of patients could not affirm if they will agree to the use of donor gamete or zygote for their treatment. Conclusion: Awareness of assisted conception treatment was high, however knowledge on specifics of treatment was low and perception on some of the practices was unfavorable. Sensitization of the public will help overcome some beliefs that may be at tangent to some practices of assisted conception.

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Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Awareness and perception of assisted reproductive technology practice amongst women with infertility in Northern Nigeria

Adesiyun¹,

Ameh²,

Solomon³

et al. 2011

OJOG

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“…[50] In Nigeria there are higher rates of irreversible oligospermia or azoospermia than most other causes of infertility and less resources for the management of infertility. [52] Of adult couples in African countries, it is estimated that 10-25% are subfertile and of these subfertile couples, female factors account for about 55% and male factors for about 30-40% of causes, whereas 5-15% of causes are unexplained. [50]…”

Section: Introductionmentioning

confidence: 99%

Lead and cadmium in public health in Nigeria: physicians neglect and pitfall in patient management

Orisakwe

2014

North Am J Med Sci

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Low-level heavy metals exposure may contribute much more toward the causation of chronic disease and impaired functioning than previously thought. Among the suggested preventive and intervention measures for the control of renal diseases are the reduction in the exposure to heavy metals. Although these indicate knowledge and awareness of possible role of some heavy metals in the etiogenesis of some chronic diseases by Nigerian Physicians, heavy metal assay as diagnostic guide in patient management is often omitted in most healthcare settings. This is a synoptic capture of the increased incidence and prevalence of some metabolic disorders where heavy metals may be implicated. A search of the terms heavy metal exposure, source, toxicity, metabolic disorders, poisoning in Nigeria, in bibliographical databases (in English language) such as PubMed, Scopus, Google Scholar, and Africa Journal Online (AJOL) digital library was conducted. Leaded gasoline, refuse dumping, absence of poison information centers, and poor record keeping characterize environmental health in Nigeria. Lead and cadmium are of most significant public health importance in Nigeria. The recognition and inclusion of heavy metals assays in the diagnosis of metabolic disorders may ensure early diagnosis and improve management.

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“…Environmental pollution and indiscriminate use of herbal medications have tended to add burden on male infertility in sub Sahara Africa (Amadi et al, 2011; Orisakwe et al, 2014). In Nigeria there are higher rates of irreversible oligospermia or azoospermia than most other causes of infertility and less resources for the management of infertility (Osegbe and Amaku, 1985). …”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Pleurotus tuber-regium on Carbon- Tetrachloride Induced Testicular Injury in Sprague Dawley Rats

2016

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The high rate of male infertility and the meager resources to manage same in sub Saharan Africa have necessitated the search for cost effective and available alternatives. Mushrooms have been used traditionally in folk medicine and as nutraceuticals. This study has investigated the effect of the wild mushroom Pleurotus tuber-regium on carbon tetrachloride (CCl4) deleterious effects on the reproductive system of male rats. Thirty six rats were divided into six groups of six animals each. Group I (negative control) received 10 ml/kg olive oil intraperitoneal weekly in addition to feed and water ad libitum. Group II (positive control) received CCl4 10 ml/kg (30% in Olive oil) weekly. Group III, IV, and V received 100 mg, 20 0mg, and 500 mg P. tuber-regium (33.3% in feed) daily in addition to 10 ml/kg CCl4 weekly. Group VI received 500 mg P. tuber-regium (33.3% in feed) daily. After 4 weeks, sperm motility, epididymal count and vitality were determined. Serum malondialdehyde (MDA), testosterone, Luteinizing hormone (LH), Follicle stimulating hormone (FSH), prolactin and oestradiol were estimated using enzyme-linked immunosorbent assay (ELISA) kits. Histopathologic examinations of the testis were carried out. Carbon tetrachloride significantly reduced the sperm motility (54.33 ± 3.79%), epididymal count (28.73 ± 2.86 × 106/ml, vitality (4.96 ± 0.62), LH (0.88 ± 0.14), FSH (2.04 ± 0.33), and Testosterone (2.02 ± 0.24) when compared with control (89.33 ± 9.01), 91.91 ± 1.92 × 106/ml, 13.12 ± 0.19, 2.74 ± 0.32, 3.64 ± 0.62, and 4.16 ± 0.23, respectively, which were reversed by P. tuber-regium administration. Co-administration of P. tuber-regium plus CCl4 significantly reduced MDA level. P. tuber-regium showed dose dependent ameliorative activity against CCl4 deleterious action on the testis and may be beneficial in the management of male infertility.

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The causes of male infertility in 504 consecutive Nigerian patients

Cited by 27 publications

References 40 publications

Awareness and perception of assisted reproductive technology practice amongst women with infertility in Northern Nigeria

Awareness and perception of assisted reproductive technology practice amongst women with infertility in Northern Nigeria

Lead and cadmium in public health in Nigeria: physicians neglect and pitfall in patient management

Protective Effects of Pleurotus tuber-regium on Carbon- Tetrachloride Induced Testicular Injury in Sprague Dawley Rats

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