The Breadth and Intensity of Supercritical Particle Formation Research with an Emphasis on Publication and Patent Disclosures

Abstract

The drawbacks of the conventional mechanical treatments for particle micronization often resulting in product damage or performance degradation have highlighted the need for alternative particle formation processes. The aim of this study was to shed light on the trends of the scientific studies and innovations in the field of particle formation using supercritical fluids (SCF) in order to observe the progress of science and technology and to satisfy the need for a global view of research activities. The publications in the ISI Web and the patents in a patent database were screened using nine different keywords in title or topics. A total of 939 journal publication and 206 patent disclosures between 1980-2009, with the contributions of 3588 authors and 604 innovators, were found to focus on particle formation using SCF. The results showed that the majority of the publication (59.2%) and patent (40.3%) disclosures were related to antisolvent precipitation and rapid expansion of SCF (18.3,16%). Patents originating from United States (56.8%) were dominating, followed by those from the European Union (30.1%) and Japan (9.2%). The analysis revealed the appetite of the companies for commercialization (73.8%), which can be interpreted as an indicator of upcoming industrial applications.

Cytotoxic and Nitric Oxide Inhibition Activities of Propolis Extract along with Microencapsulation by Complex Coacervation

“…Microencapsulation is an alternative approach to overcome these drawbacks particularly by masking the unpleasant taste of ingredients and enhancing the stabilityt. Both conventional encapsulation techniques and more advanced approaches such as supercritical antisolvent processes are applied to obtain encapsulated particles ranging from micro-to nanometers [7,8]. Propolis has been encapsulated with different methods but only one study focused on encapsulation of ethanol extract of propolis (EEP) by complex coacervation where soy protein and pectin were used as wall materials [3].…”

Technology Resource, Distribution, and Development Characteristics of Global Influenza Virus Vaccine: A Patent Bibliometric Analysis

“…Later, another study showed a bibliometric analysis of the patents and scientific publications in the laser cladding field from 1985 to 2007 [ 5 ]. In 2010, using supercritical fluids, Yesil-Celiktas and Senyay shed light on the trends of the scientific studies and innovations in the field of particle formation [ 6 ]. One year later, patent bibliometric analysis was used for tracking the R&D behavior in the pharmaceutical industry [ 7 ].…”

Formation of microcapsules containing titanium dioxide nanoparticles by pulse expansion of a supercritical solution into a background gas

“…The RESS method occupies one of the leading places in publications and patents devoted to creating nanoparticles using SCF [4]. The continuous flow mode of various modifications of the RESS method is attractive for SCF technologies for its simplicity and low equipment cost.…”