The blood flow characteristics of polypoidal choroidal vasculopathy and the choroidal remodelling process after photodynamic therapy

Chen, Yutong; Yang, Zhi; Xia, Fan; Ning, Hong; Hua, Rui

doi:10.1002/lsm.22801

Cited by 12 publications

(8 citation statements)

References 17 publications

(23 reference statements)

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“…Therefore, we presumed that focal enhancement of CVI and choroidal thickness cannot fully indicate PSD status; furthermore, some PSD eyes had increased choroidal thickness outside the fovea. Importantly, we previously showed that choroidal thickness at polyp sites was positively associated with polyp size, while choroidal thickness did not significantly differ between foveal and polyp sites ( 33 ); our current findings are consistent with these results.…”

Section: Discussionsupporting

confidence: 92%

Imaging Characteristics of Neovascular and Atrophic Pachychoroidal Spectrum Diseases

Hua

Zhang

2022

Front. Med.

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BackgroundThis study qualitatively and quantitatively compared imaging characteristics between neovascular and atrophic pachychoroid spectrum disease (PSD) by optical coherence tomography (OCT), and OCT angiography (OCTA).MethodsThe subtypes of PSD were identified by multi-modality imaging approaches. Subfoveal choroidal thickness (SFCT), choroidal vascular index (CVI), and vascular density of choroidal neovascularization (CNV) were measured.ResultsThe CVI and SFCT of 174 PSD eyes were 67.6% ± 5.48% and 362.2 ± 131.88 μm, respectively. After adjustment for age, linear regression indicated that SFCT was positively associated with CVI (p < 0.001), and patched hyper-reflective lesions in choriocapillaris layers (p = 0.009). Compared with neovascular PSD eyes, atrophic PSD eyes had similar patient age (57.1 ± 16.72 years, p = 0.639), SFCT (332.0 ± 111.00 μm, p = 0.51), and CVI (67.6% ± 3.94%, p = 0.527). There were no differences between polypoidal choroidal vasculopathy (PCV) eyes with aneurysmal polypoidal lesions and PCV eyes with tangled polypoidal lesions in terms of age, CVI, SFCT, vascular density, or the occurrence of double layer signs (DLSs, all p > 0.05). Logistic regression indicated that age (p = 0.003), SFCT (p = 0.003), patched hyper-reflective lesions in choriocapillaris layers (p = 0.009), and DLSs (p < 0.001) were predictive factors for CNV progression in PSD eyes (all p < 0.05).ConclusionsOur study highlighted the similarities in SFCT and CVI between neovascular and atrophic PSD, both of which were late stage lesions. Besides, age, SFCT, patched hyper-reflective lesions in choriocapillaris layers, and DLSs were risk factors for CNV in PSD. Our results showed that atrophic PSD is an important change in the late stage of PSD disease, which is helpful for in-depth understanding of the pathological mechanism of PSD and corresponding intervention.

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Section: Discussionsupporting

confidence: 92%

Imaging Characteristics of Neovascular and Atrophic Pachychoroidal Spectrum Diseases

Hua

Zhang

2022

Front. Med.

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“…Other non-invasive imaging systems that have been used or currently under development for evaluation of dermal vasculatures include laser Doppler flowmeter, laser Doppler imaging, dermoscopy, cross-polarized diffuse reflection color imaging system, and optical coherence tomography [39][40][41][42][43][44][45][46][47][48]. The main feature of RCM is that it can directly reveal the dermal structure in a simple and fast way, which makes it be a promising bedside tool for prognostic evaluation.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Laser‐Resistant Port Wine Stain Blood Vessels Using In Vivo Reflectance Confocal Microscopy

Huang

Xiang

et al. 2019

Lasers Surg Med

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Background and Objectives Port wine stain (PWS) is a congenital vascular malformation of the human skin. Laser is the treatment of choice for PWS. Laser‐resistant PWS is one crucial factor accounting for inadequate treatment outcome, which needs to be fully characterized. This study aims to quantitatively characterize the morphology of laser‐resistant PWS blood vessels in the upper papillary dermis using in vivo reflectance confocal microscopy (RCM). Study Design/Materials and Methods A total of 42 PWS subjects receiving laser treatment from August 2016 through July 2018 were enrolled into this study. Thirty‐three subjects had facial PWS; nine had extremity PWS. All subject's PWS received multiplex 585/1,064 nm laser treatment. RCM images were taken before and after treatment. The density, diameter, blood flow, and depth of PWS blood vessels were analyzed. Results We found 44.4% PWS on the extremities (four out of nine subjects) were laser‐resistant, which was significantly higher (P < 0.001) when compared with those PWS on the face (15.2%, 5 out of 33 subjects). The laser‐resistant facial PWS blood vessels had significantly higher blood flow (1.35 ± 0.26 U vs. 0.89 ± 0.22 U, P < 0.001), larger blood vessel diameters (109.60 ± 18.24 µm vs. 84.36 ± 24.04 µm, P = 0.033) and were located deeper in the skin (106.01 ± 13.87 µm vs. 87.82 ± 12.57 µm, P < 0.001) in the skin when compared with laser‐responsive PWS on the face. The average PWS blood vessel density (17.01 ± 4.63/mm2 vs. 16.61 ± 4.44/mm2, P = 0.857) was not correlated to the laser resistance. Conclusions Laser‐resistant PWS blood vessels had significantly higher blood flow, larger diameters, and were located deeper in the skin. RCM can be a valuable tool for a prognostic evaluation on laser‐resistant lesions before treatment, thereby providing guidance for tailored laser treatment protocols, which may improve the therapeutic outcome. The limitations for this study include relative small sample size and acquisitions of different blood vessels before and after 2 months of treatment. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

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“…We read with interest the article by Chen et al describing choroidal remodeling in eyes with polypoidal choroidal vasculopathy (PCV) following treatment with verteporfin photodynamic therapy (PDT). Using spectral‐domain optical coherence tomography (OCT), the authors reported early increases in central foveal thickness, subretinal fluid height, and choroidal thickness after PDT.…”

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confidence: 99%

“…Using spectral‐domain optical coherence tomography (OCT), the authors reported early increases in central foveal thickness, subretinal fluid height, and choroidal thickness after PDT. At a subsequent review performed between 1 to 3 months, the above parameters were reduced compared to baseline .…”

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Choroidal remodeling after photodynamic therapy for polypoidal choroidal vasculopathy

2018

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The blood flow characteristics of polypoidal choroidal vasculopathy and the choroidal remodelling process after photodynamic therapy

Cited by 12 publications

References 17 publications

Imaging Characteristics of Neovascular and Atrophic Pachychoroidal Spectrum Diseases

Imaging Characteristics of Neovascular and Atrophic Pachychoroidal Spectrum Diseases

Characterization of Laser‐Resistant Port Wine Stain Blood Vessels Using In Vivo Reflectance Confocal Microscopy

Choroidal remodeling after photodynamic therapy for polypoidal choroidal vasculopathy

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