The Birmingham Oral Contraceptive Trial

"Conovid-E" as an Oral Contraceptive

“…This was simbilar to those already described elsewhere (Eckstein et at., 1961 ;Mears, 1961 ;Mears and Grant, 1962). The ralationship between the general practitioners, the consultants, and the clinic was very good.…”

"Anovlar" as an Oral Contraceptive

“…To these, discovery is an art rather than a science; a matter of instinct rather than The two most promising and most extensively tested progestational compounds to be used as oral contraceptives are norethynodrel and norethisterone. Norethynodrel was the first to be used in large-scale trials in this country under the auspices of the Council for the Investigation of Fertility Control in Birmingham, Slough, and London, and some of the results have already been published (Eckstein et al;Mears, 1961). The 5-mg. tablet of norethynodrel containing 0.075 mg. of ethinyloestradiol-3-methyl ether (" conovid ") was also the first oral contraceptive to be approved by C.I.F.C.…”

“…The organization of largescale trials under the auspices of C.I.F.C. has already been described in detail (Eckstein et al, 1961 ;Mears, 1961). The volunteers had to satisfy the following criteria: to be under 40 years at the time of beginning the trial, to have proved their fertility, to have at least one living child of the present marriage, to have had not more abortions than children, to have a body weight not exceeding 11 stone (70 kg.…”

Some Metabolic Actions and Possible Toxic Effects of Hormonal Contraceptives in Animals and Man

“…1970). Clinically mestranol inhibits ovulation at doses of 75 pg, 80 µ , or 100 pg, but not at doses of 36 pg or 40 pg (Eckstein et al 1961;Martinez-Manautou 1965;Goldzieher et al 1963;Yen 1965;Guai et al 1967). Ethynyloestradiol inhibits ovulation at doses of 50 pg but not at 20 pg (Guai et al 1967;Lyon 1943;Martinez-Manautou et al 1964).…”