"Anovlar" as an Oral Contraceptive

Mears, Eleanor; Grant, Ellen C. G.

doi:10.1136/bmj.2.5297.75

Cited by 71 publications

(11 citation statements)

References 4 publications

(10 reference statements)

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“…Further support for a relationship between hormonal variations and migraine includes reports of the oral contraceptive pill precipitating a first attack of migraine, or worsening or improving the frequency and severity of existing attacks [Dalton, 1976;Kudrow, 1975;Larson-Cohn and Lundberg, 1970;Mears and Grant, 1962;Phillips, 1968;Ryan, 1978;Whitty et al, 1966]. In addition, many women with migraine have fewer attacks during pregnancy [Callaghann, 1968;Nattero, 1982;Somerville, 1972], although the condition may be exacerbated in the postpartum period [Stein, 1981].…”

Section: Genetic Influence and Sex-limitationmentioning

confidence: 94%

Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities

Nyholt

Gillespie

Heath

et al. 2004

Genetic Epidemiology

114

121

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Latent class and genetic analyses were used to identify subgroups of migraine sufferers in a community sample of 6,265 Australian twins (55% female) aged 25-36 who had completed an interview based on International Headache Society (IHS) criteria. Consistent with prevalence rates from other population-based studies, 703 (20%) female and 250 (9%) male twins satisfied the IHS criteria for migraine without aura (MO), and of these, 432 (13%) female and 166 (6%) male twins satisfied the criteria for migraine with aura (MA) as indicated by visual symptoms. Latent class analysis (LCA) of IHS symptoms identified three major symptomatic classes, representing 1) a mild form of recurrent nonmigrainous headache, 2) a moderately severe form of migraine, typically without visual aura symptoms (although 40% of individuals in this class were positive for aura), and 3) a severe form of migraine typically with visual aura symptoms (although 24% of individuals were negative for aura). Using the LCA classification, many more individuals were considered affected to some degree than when using IHS criteria (35% vs. 13%). Furthermore, genetic model fitting indicated a greater genetic contribution to migraine using the LCA classification (heritability, h(2)=0.40; 95% CI, 0.29-0.46) compared with the IHS classification (h(2)=0.36; 95% CI, 0.22-0.42). Exploratory latent class modeling, fitting up to 10 classes, did not identify classes corresponding to either the IHS MO or MA classification. Our data indicate the existence of a continuum of severity, with MA more severe but not etiologically distinct from MO. In searching for predisposing genes, we should therefore expect to find some genes that may underlie all major recurrent headache subtypes, with modifying genetic or environmental factors that may lead to differential expression of the liability for migraine.

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Section: Genetic Influence and Sex-limitationmentioning

confidence: 94%

Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities

Nyholt

Gillespie

Heath

et al. 2004

Genetic Epidemiology

114

121

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show abstract

“…but no controls for placebo effects were included. Mears & Grant (1962) in a further uncontrolled study found that 60q, of PMS sufferers reported a decrease in symptoms, 269, an increase and I4y0 no change, though, as in many such studies, the assessment of PMS was extremely superficial.…”

Section: Manipulation Of the Ovarian Cyclementioning

confidence: 99%

Premenstrual Syndrome

Bancroft¹,

Bäckström²

1985

Clinical Endocrinology

100

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“…3 gives the structure of the three remaining compounds under 158 Margaret C. N. Jackson consideration today. Chlormadinone-with a halogen group at 6 instead of a methyl group, but otherwise very similar in structure to the compounds shown (Mears, 1961 ;Mears & Grant, 1962) gives a fall-out rate of about 12%, while Dr D. Pullen (1962) Bowman (1962), on the other hand, observed no effect on lactation in women given norethisterone acetate as a contraceptive. Lehfeldt (1962) reports that lactation is disturbed in a high proportion of cases on oral gestagens.…”

Section: Definition Of Field Under Review and Methods Of Evaluating Pmentioning

confidence: 99%

Oral Contraception in Practice

Jackson¹

1963

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"Anovlar" as an Oral Contraceptive

Cited by 71 publications

References 4 publications

Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities

Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities

Premenstrual Syndrome

Oral Contraception in Practice

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