The biosynthesis of prostaglandin in pig eye iris

Dorp, D. A. van; Jouvenaz, G.H.; Struijk, C.B.

doi:10.1016/0005-2760(67)90117-8

Cited by 40 publications

(1 citation statement)

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“…Dorp, Jouvenaz & Struijk (1967) also showed that pig iris could convert all cis-8,11,14-eicosatrienoic acid into prostaglandins E1 and Fl, Several workers have made pharmacological comparisons of prostaglandins on isolated iris smooth muscle. The dog and cat sphincter muscles are of particular interest since prostaglandin F2.…”

Section: Introductionmentioning

confidence: 99%

Effects of Prostaglandins and Thromboxane Analogues on Bullock and Dog Iris Sphincter Preparations

Duan

Jones

1982

British J Pharmacology

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1 The bullock iris sphincter was contracted by low concentrations of prostaglandin E2 (PGE2), 16,18,19,. Other compounds with thromboxane-like actions, for example 11,9-epoxymethano PGH2, were also potent spasmogens. ZK 36374, a stable carbacyclin, was a partial agonist on the PGE-sensitive system of this tissue. 2 The thromboxane antagonist, EP 045, had little effect on the action of PGE2 and 16,16-dimethyl PGE2 on the bullock iris.3 The dog iris sphincter was sensitive to PGF2 but not to PGE2 and 11,9-epoxymethano PGH2.4 16,16-Dimethyl PGE2 had very low activity on the dog iris in contrast to its high activity on the bullock iris. The reverse was found with the 17,18,19,20-tetranor-16-m-trifluoromethylphenoxy analogue of PGF2a (ICI 81008). This indicates a considerable selectivity of action of the two analogues.5 The results are discussed in relation to the existing knowledge of prostanoid receptors.

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Section: Introductionmentioning

confidence: 99%