The biomimetic design and 3D printing of customized mechanical properties porous Ti6Al4V scaffold for load-bearing bone reconstruction

Zhang, Boqing; Pei, Xuan; Zhou, Changchun; Fan, Yujiang; Jiang, Qing; Ronca, Alfredo; D’Amora, Ugo; Chen, Yu; Li, Huiyong; Sun, Yong; Zhang, Xingdong

doi:10.1016/j.matdes.2018.04.065

Cited by 233 publications

(121 citation statements)

References 56 publications

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“…Internal 3D structures are then fabricated by reproducing these slices one layer at a time by using a sized nozzle (direct extrusion printing) or a programmed selective sintering laser (selective laser melting, SLM), electron beam melting (EBM), or a specific curing light (stereo lithography apparatus, SLA). So far, 3D printing technology has successfully printed various bioceramics, polymers, metal materials, and other biocompatible materials for bone tissue engineering scaffolds [37][38][39]. These printed scaffolds have highly complicated geometrical architectures with personalcustomized shape for different patients in accordance with their CT data.…”

Section: Advanced Technology For Thementioning

confidence: 99%

Regulation and Directing Stem Cell Fate by Tissue Engineering Functional Microenvironments: Scaffold Physical and Chemical Cues

Xing

Zhou

et al. 2019

Stem Cells International

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It is well known that stem cells reside within tissue engineering functional microenvironments that physically localize them and direct their stem cell fate. Recent efforts in the development of more complex and engineered scaffold technologies, together with new understanding of stem cell behavior in vitro, have provided a new impetus to study regulation and directing stem cell fate. A variety of tissue engineering technologies have been developed to regulate the fate of stem cells. Traditional methods to change the fate of stem cells are adding growth factors or some signaling pathways. In recent years, many studies have revealed that the geometrical microenvironment played an essential role in regulating the fate of stem cells, and the physical factors of scaffolds including mechanical properties, pore sizes, porosity, surface stiffness, three-dimensional structures, and mechanical stimulation may affect the fate of stem cells. Chemical factors such as cell-adhesive ligands and exogenous growth factors would also regulate the fate of stem cells. Understanding how these physical and chemical cues affect the fate of stem cells is essential for building more complex and controlled scaffolds for directing stem cell fate.

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Section: Advanced Technology For Thementioning

confidence: 99%

Regulation and Directing Stem Cell Fate by Tissue Engineering Functional Microenvironments: Scaffold Physical and Chemical Cues

Xing

Zhou

et al. 2019

Stem Cells International

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“…Additive manufacturing (AM) technology has currently gained intensive attention for fabricating synthetic bone scaffolds as orthopedics implants [5][6][7][8][9]. Unlike the conventional material removal processes, AM involves a whole host of 'bottom up' approaches, which creates three dimensional objects originated from computerdesigned models by gradually building them up with a layer-by-layer method [10,11].…”

Section: Introductionmentioning

confidence: 99%

Selective laser melted Fe-Mn bone scaffold: microstructure, corrosion behavior and cell response

Shuai

Yang

et al. 2020

Mater. Res. Express

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Iron metal possesses good biocompatibility and excellent mechanical strength, though it degrades too slowly. In this work, selective laser melting (SLM) was applied to fabricate iron-manganese (Fe-Mn) biodegradable scaffold. Results shown Fe-Mn scaffold exhibited a uniform pore structure with a porosity of 66.72±2.3%, which highly matched with as-designed model. Phase analysis revealed Fe-Mn scaffold mainly contained α-Fe, martensitic and austenitic phases. Due to the potential difference among these different phases, galvanic corrosion occurred in Fe matrix. In addition, a small amount of Mn distributed at grain boundaries also contributed to the formation of galvanic corrosion. Thus, the corrosion rate increased from 0.09±0.02 mm/year to 0.23±0.05 mm/year. The scaffold exhibited suitable mechanical properties with a yield strength of 137±8.4 MPa, an ultimate strength of 221.7±10.9 MPa. Moreover, cell assays demonstrated its good cytocompatibility. Taking these positive results into consideration, SLM processed Fe-Mn scaffold was a promising material for bone repair application.

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“…In this work, the authors compared the architecture and mechanical performance of solid free-form scaffolds composed by a Ti6Al4 V alloy. The Ti6Al4 V alloy is one of the most commonly used implants in orthopedic surgery and already showed promising results in terms of in vitro and in vivo performance [23]. The scaffolds were produced by selective laser melting (SLM) and electron beam melting (EBM).…”

Section: Stereolithographymentioning

confidence: 99%

Current advances in solid free-form techniques for osteochondral tissue engineering

et al. 2018

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Osteochondral (OC) lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds' processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form (SFF) techniques. These techniques allow tuning different properties at the micro-macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.

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The biomimetic design and 3D printing of customized mechanical properties porous Ti6Al4V scaffold for load-bearing bone reconstruction

Cited by 233 publications

References 56 publications

Regulation and Directing Stem Cell Fate by Tissue Engineering Functional Microenvironments: Scaffold Physical and Chemical Cues

Regulation and Directing Stem Cell Fate by Tissue Engineering Functional Microenvironments: Scaffold Physical and Chemical Cues

Selective laser melted Fe-Mn bone scaffold: microstructure, corrosion behavior and cell response

Current advances in solid free-form techniques for osteochondral tissue engineering

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