2008
DOI: 10.1089/ten.teb.2008.0062
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The Biology of Platelet-Rich Plasma and Its Application in Oral Surgery: Literature Review

Abstract: Platelet-rich plasma (PRP) is a new approach in tissue regeneration and a developing area for clinicians and researchers. It is used in various surgical fields, including oral and maxillofacial surgery. PRP is prepared from the patient's own blood and contains growth factors that influence wound healing. Of these growth factors, platelet-derived growth factor, transforming growth factor, insulin-like growth factor, and epidermal growth factor play a pivotal role in tissue repair mechanisms. Although the growth… Show more

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Cited by 222 publications
(190 citation statements)
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“…The interaction between these bioactive proteins and receptors has a key role in the process of wound healing 7,8 . PRP is used in the treatment of chronic cutaneous and soft tissue ulcerations and especially in periodontal and oral surgery, maxillofacial surgery, orthopedic and traumatic surgery, cosmetic and plastic surgery, spinal surgery, heart by-pass surgery, and in burns [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] . The purpose of our study was to examine the histopathological effects of topical PRP and PPP treatments in wound healing on rats with partial thickness wounds.…”
Section: Introductionmentioning
confidence: 99%
“…The interaction between these bioactive proteins and receptors has a key role in the process of wound healing 7,8 . PRP is used in the treatment of chronic cutaneous and soft tissue ulcerations and especially in periodontal and oral surgery, maxillofacial surgery, orthopedic and traumatic surgery, cosmetic and plastic surgery, spinal surgery, heart by-pass surgery, and in burns [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] . The purpose of our study was to examine the histopathological effects of topical PRP and PPP treatments in wound healing on rats with partial thickness wounds.…”
Section: Introductionmentioning
confidence: 99%
“…Polymers like PGA-hyaluronan for in vivo cartilage tissue repair reportedly gave rise to hyaline cartilage in animal studies [7,8] and in clinical applications [22,38]. PRP has been used in trauma and orthopaedic surgery [1,27,30] because it is an autologous source of various growth factors [21]. Injection of PRP in 115 knees with chronic degenerative symptoms reduced pain and improved knee function and quality of life in younger patients as assessed by International Knee Documentation Committee (IKDC) score and visual analog scale (VAS) score at 1 and 2 years of followup [6,17].…”
Section: Introductionmentioning
confidence: 99%
“…14 PRP contains high amounts of growth factors, which are available in the a-granules and can be delivered continuously by activation of the platelets. 15 Amongst others, the a-granules may release growth factors such as PDGF, transforming growth factor-beta (TGFB), IGF1, platelet-derived angiogenesis factor (PDAF), VEGF, and epidermal growth factor (EGF). 16,17 In addition, chemokines are released like CCL3, CCL5, CCL 7, CCL 17, or CXCL 1 and CXCL 12 that may lead to the migration of progenitor cells from the bone marrow.…”
mentioning
confidence: 99%