“…14 PRP contains high amounts of growth factors, which are available in the a-granules and can be delivered continuously by activation of the platelets. 15 Amongst others, the a-granules may release growth factors such as PDGF, transforming growth factor-beta (TGFB), IGF1, platelet-derived angiogenesis factor (PDAF), VEGF, and epidermal growth factor (EGF). 16,17 In addition, chemokines are released like CCL3, CCL5, CCL 7, CCL 17, or CXCL 1 and CXCL 12 that may lead to the migration of progenitor cells from the bone marrow.…”