A Cell-free Scaffold-based Cartilage Repair Provides Improved Function Hyaline-like Repair at One year

Siclari, Alberto; Mascaro, Gennaro; Gentili, Chiara; Cancedda, Ranieri; Boux, E.

doi:10.1007/s11999-011-2107-4

Cited by 119 publications

(124 citation statements)

References 33 publications

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“…Because of PRP's prominent role in anti-inflammation and fewer immunogenic as well as more biocompatible characteristics, the cell-free polyglycolic acid (PGA)-hyaluronan scaffold combined with PRP led to cartilage repair and improved patient-reported outcomes (the Knee injury and Osteoarthritis Score, KOOS) during 12 months of follow-up. 28 Moreover, TGF-b, delivered together with calcium alginate to the sites of osteochondral defects, improved the repair of osteochondral defects in the rabbit knee. 29 However, the local production of osteophytes has been observed in clinical trials; therefore, caution is advised because some growth factors favor the dedifferentiation of stem cells and promote the endochondral ossification process.…”

Section: Growth Factorsmentioning

confidence: 99%

Anti-Inflammatory Strategies in Cartilage Repair

Zhang

Pizzute

Pei

2014

Tissue Engineering Part B: Reviews

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Section: Growth Factorsmentioning

confidence: 99%

Anti-Inflammatory Strategies in Cartilage Repair

Zhang

Pizzute

Pei

2014

Tissue Engineering Part B: Reviews

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“…To be more precise, only two studies were related to knee osteochondral defects (Scilari's and Dolander's studies) and one related to ankle osteochondral defects (Mae-Dan's study) [36][37][38]. In the case of Ozone, there is only one study Fernández-Cuadros [25] that supports its treatment on PFPS/ Chondromalacia.…”

Section: Discussionmentioning

confidence: 99%

Efficiency of Platelet-rich Plasma (PRP) Compared to Ozone Infiltrations on Patellofemoral Pain Syndrome and Chondromalacia: A Non- Randomized Parallel Controlled Trial

Fernández-Cuadros¹,

Albaladejo-Florín²,

Algarra-López³

et al. 2017

Divers Equal Health Care

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Objective: 1) to determine the efficiency of PRP compared to Ozone Infiltrations on pain, function and quality of life (QoL) in patients with Patellofemoral Pain Syndrome (PFPS) and Chondromalacia. Material and methods:Prospective non-randomized controlled-trial, comparing two treatment protocols in parallel design, on 48 patients (24 in each group), with PFPS and Chondromalacia , who were treated at Santa Cristina's University Hospital, from January 2014 to May 2017. The PRP-protocol consisted of 3 sessions (1 session/week) of platelet-rich plasma (PRP), by an intra-articular infiltration of 3 ml. To obtain PRP, a kit device from EXACTECH (Accelerate Concentration System Device and Drucker Centrifuge was used.The Ozone-protocol consisted of 4 sessions (1 per week) of a medical mixture of Oxygen-Ozone (95%-5%) 20 ml, at a 20 ug/ml concentration, infiltrated intra-articularly. Pain, function, stiffness and Quality of Life were measured by Western Ontario and Mc Master Universities Index for Osteoarthritis (WOMAC) and Visual Analogical Scale (VAS) at baseline/end of treatment.Results: At baseline, age, sex, ratio male to female, clinical chondromalacia grades and symptom severity such as pain, stiffness and function were similar between groups of treatment. In both groups, the most common grade of chondromalacia was 2º grade (41.8% in PRP, 50% in Ozone), followed by 3º (37.6% in PRP, 33.4% in Ozone) and 4º (16.6% in both PRP and Ozone). When treatment protocols are analyzed separately, both PRP and Ozone were capable to produce pain relief (measured by VAS and WOMAC pain subscale), and improvement in function and rigidity (measured by WOMAC subscales), with a significant statistical level (p<0.05). In the case of pain, Ozone is even more effective than PRP (1.46 points on VAS scale and 2.95 points on WOMAC pain subscale) (p<0.05).Conclusion: PRP and ozone produce pain relief, function recovery and quality of life improvement in PFPS and chondromalacia, measured by WOMAC and VAS scores. In the case of pain severity, ozone produces even greater pain relief. PRP and Ozone are safe and effective modalities for the management of PFPS and chondromalacia.

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“…Adding different organic scaffolds to concentrate and stimulate stem cell differentiation can augment the microfracture procedure or promote the in vitro or in situ diff erentiation of BMSC-engineered tissue, thereby improving hyaline quality and increasing fi ll percentage (Gomoll, 2012;Siclari et al, 2012). However, although many scaff old strategies have good in vitro or in vivo outcomes in animal models, their use for cartilage repair in humans has been discouraged Kraan et al, 2002).…”

Section: Stem Cell Therapymentioning

confidence: 99%

Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation

Montoya¹,

Martínez²,

García-Robles³

et al. 2013

Biol. Res.

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Cartilage has poor regeneration capacity due to the scarcity of endogenous stem cells, its low metabolic activity and the avascular environment. Repair strategies vary widely, including microfracture, autologous or allogenic tissue implantation, and in vitro engineered tissues of autologous origin. However, unlike the advances that have been made over more than two decades with more complex organs, including vascular, cardiac or bone tissues, similar advances in tissue engineering for cartilage repair are lacking. Although the inherent characteristics of cartilage tissue, such as the lack of vascularity and low cellular diversity, suggest that it would be one of the more simple tissues to be engineered, its functional weight-bearing role and implant viability and adaptation make this type of repair more complex. Over the last decade several therapeutic approaches and innovative techniques show promise for lasting and functional regeneration of hyaline cartilage. Here we will analyze the main strategies for cartilage regeneration and discuss our experience.

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A Cell-free Scaffold-based Cartilage Repair Provides Improved Function Hyaline-like Repair at One year

Cited by 119 publications

References 33 publications

Anti-Inflammatory Strategies in Cartilage Repair

Anti-Inflammatory Strategies in Cartilage Repair

Efficiency of Platelet-rich Plasma (PRP) Compared to Ozone Infiltrations on Patellofemoral Pain Syndrome and Chondromalacia: A Non- Randomized Parallel Controlled Trial

Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation

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