The Biocompatibility of Implant Materials

Electrospun Polyethylene Terephthalate Nanofibers Loaded with Silver Nanoparticles: Novel Approach in Anti-Infective Therapy

“…Injection or implantation of a biomaterial results in an acute inflammation response, which is most often followed by a chronic inflammatory reaction [42], characterized by the infiltration of polymorphonuclear neutrophils (PMN), macrophages, and eventually lymphocytes [43]. The inflammatory reactions toward the novel in situ PET_X_NanoAg materials were weak, being within the limits of a typical, normal reaction to implanted materials characterized by the accumulation of the inflammatory cells on the materials surface.…”

Biocompatibility of Polyimides: A Mini-Review

“…The term “biocompatibility”, the “holy grail” of any researcher working in the biomaterial or medical domains, has reached such a common and careless usage in countless areas and contexts that its sense and gravity have been attenuated and blurred [17]. On one side, there is a constant fluctuation in its operation and significance.…”

“…The definition accepted by the academic majority is “the ability of a material to perform with an appropriate host response in a specific application”. There is also an expanded version that includes the concept of “bioactivity” (an action stimulated by the material) and thus becomes much wider than simple inertia [17,18]. This comes as a necessary complement of the IUPAC (International Union of Pure and Applied Chemistry) definition which describes biocompatibility as the “ability to be in contact with a living system without producing an adverse effect” [56].…”

“…PIs are engineered starting from a rather small collection of building blocks which nevertheless provide a broad range of PI formulations. This wide PI variety demands more data, interpretations, and correlations to achieve the “biocompatible” label since even a small change in the macromolecular architecture can generate noticeable differences in terms of cytotoxicity, thrombogenicity, interaction with various cells and tissues, biostability and many others [17,18]. Ultimately, each polyimidic material intended to be employed in any biomedical application needs to be severely tested.…”

Design and Synthesis of a γ1β8‐Cyclodextrin Oligomer: A New Platform with Potential Application as a Dendrimeric Multicarrier

“…Hydrogels are polymeric materials that do not dissolve in water at physiological temperature and pH but swell considerably in an aqueous medium 1, 2. Ionic polymer hydrogels have been known to be bent in an electric field.…”