Electrospun Polyethylene Terephthalate Nanofibers Loaded with Silver Nanoparticles: Novel Approach in Anti-Infective Therapy

Grumezescu, Valentina; Stoica, Anca‐Iulia; Dima-Bălcescu, Mihnea-Ștefan; Chircov, Cristina; Gharbia, Sami; Baltă, Cornel; Rosu, Marcel; Herman, Hildegard; Holban, Alina Maria; Ficai, Anton; Vasile, Bogdan Ștefan; Andronescu, Ecaterina; Chifiriuc, Mariana Carmen

doi:10.3390/jcm8071039

Cited by 36 publications

(23 citation statements)

References 58 publications

(60 reference statements)

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“…It is highly flexible, semi-crystalline, and shows excellent electrical insulating properties and high strength [ 49 ]. Poly(ethylene terephthalate) is the most common polymer for food and beverage packaging [ 50 , 51 ]; however, it can be seen in applications as automotive [ 49 ] or even medicine [ 52 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Poly(ethylene Terephthalate)/Silk Fibroin Composite for Filtration Application

et al. 2021

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In this study, fibrous membranes from recycled-poly(ethylene terephthalate)/silk fibroin (r-PSF) were prepared by electrospinning for filtration applications. The effect of silk fibroin on morphology, fibers diameters, pores size, wettability, chemical structure, thermo-mechanical properties, filtration efficiency, filtration performance, and comfort properties such as air and water vapor permeability was investigated. The filtration efficiency (FE) and quality factor (Qf), which represents filtration performance, were calculated from penetration through the membranes using aerosol particles ranging from 120 nm to 2.46 μm. The fiber diameter influenced both FE and Qf. However, the basis weight of the membranes has an effect, especially on the FE. The prepared membranes were classified according to EN149, and the most effective was assigned to the class FFP1 and according to EN1822 to the class H13. The impact of silk fibroin on the air permeability was assessed. Furthermore, the antibacterial activity against bacteria S. aureus and E. coli and biocompatibility were evaluated. It is discussed that antibacterial activity depends not only on the type of used materials but also on fibrous membranes’ surface wettability. In vitro biocompatibility of the selected samples was studied, and it was proven to be of the non-cytotoxic effect of the keratinocytes (HaCaT) after 48 h of incubation.

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Section: Introductionmentioning

confidence: 99%

Electrospun Poly(ethylene Terephthalate)/Silk Fibroin Composite for Filtration Application

et al. 2021

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“…Other applications involve the development of nanocoatings containing both inorganic and polymeric nanoparticles through various methods, such as the matrix-assisted pulsed laser evaporation. Examples of such studies include silver nanoparticles/PLA nanocoatings [ 139 ] or silver nanoparticles/polyethylene terephthalate nanofibers [ 140 ] and simple [ 141 ] or functionalized with lincomycin [ 142 ], cefepime [ 143 ], or Nigella sativa essential oils [ 144 ] magnetite nanoparticles/PLGA nanocoatings.…”

Section: Antimicrobial Applications Of Polymeric Nanoparticlesmentioning

confidence: 99%

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

et al. 2021

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Despite the many advancements in the pharmaceutical and medical fields and the development of numerous antimicrobial drugs aimed to suppress and destroy pathogenic microorganisms, infectious diseases still represent a major health threat affecting millions of lives daily. In addition to the limitations of antimicrobial drugs associated with low transportation rate, water solubility, oral bioavailability and stability, inefficient drug targeting, considerable toxicity, and limited patient compliance, the major cause for their inefficiency is the antimicrobial resistance of microorganisms. In this context, the risk of a pre-antibiotic era is a real possibility. For this reason, the research focus has shifted toward the discovery and development of novel and alternative antimicrobial agents that could overcome the challenges associated with conventional drugs. Nanotechnology is a possible alternative, as there is significant evidence of the broad-spectrum antimicrobial activity of nanomaterials and nanoparticles in particular. Moreover, owing to their considerable advantages regarding their efficient cargo dissolving, entrapment, encapsulation, or surface attachment, the possibility of forming antimicrobial groups for specific targeting and destruction, biocompatibility and biodegradability, low toxicity, and synergistic therapy, polymeric nanoparticles have received considerable attention as potential antimicrobial drug delivery agents. In this context, the aim of this paper is to provide an up-to-date overview of the most recent studies investigating polymeric nanoparticles designed for antimicrobial therapies, describing both their targeting strategies and their effects.

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“…The composite scaffolds restricted the resorption of bone passage and enhanced the biomechanical response of bone–joint interface, being potential candidates for the replacement of anterior cruciate ligament [ 332 ]. In addition, AgNPs-decorated nanofibrous membranes of PET, with good cytocompatibility and inhibitory effects against planktonic and sessile bacteria, induced weak inflammation and reduced foreign body response in an animal model [ 333 ]. Poly(acrylonitrile-butadiene-styrene) copolymers modified with AgNPs were proposed as suitable candidates for the fabrication of middle ear implants.…”

Section: Silver Nanoparticles For Tissue Engineeringmentioning

confidence: 99%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

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Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.

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Electrospun Polyethylene Terephthalate Nanofibers Loaded with Silver Nanoparticles: Novel Approach in Anti-Infective Therapy

Cited by 36 publications

References 58 publications

Electrospun Poly(ethylene Terephthalate)/Silk Fibroin Composite for Filtration Application

Electrospun Poly(ethylene Terephthalate)/Silk Fibroin Composite for Filtration Application

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

An Updated Review on Silver Nanoparticles in Biomedicine

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