The biocompatibility of a new endodontic paste used in dental trauma

Abstract

<title>Abstract</title><sec><title>Objective</title><p>This study investigated the short-term subcutaneous tissue reaction of a new endodontic paste, based on the association among calcium hydroxide [Ca(OH)<sub>2</sub>], 2% chlorhexidine gel (CHX) and zinc oxide (ZnO) in comparison with a control paste, and the individual substances alone.</p></sec><sec><title>Material and method</title><p>Twenty-four male wistar rats were used. Polyethylene tubes containing the materials were implanted into the dorsal connective tissue of rats. Empty implanted tubes served as controls. The materials used were: Ca(OH)<sub>2</sub>+CHX+ZnO paste in two different proportions (2:1:2) and (2:1:3), a control paste, Ca(OH)<sub>2</sub>+CHX (2:1), and the substances alone. After time intervals of 2, 3, 7 and 15 days, the animals were euthanized and the specimens prepared for histological processing. Data were evaluated qualitatively according to the levels of tissue repair and the degree of inflammation.</p></sec><sec><title>Result</title><p>On the second day all the materials were observed to cause a severe inflammatory response. On the third day, the pastes Ca(OH)<sub>2</sub>+CHX+ZnO (2:1:2) and (2:1:3) showed reduction in degree of inflammation. On seventh day the tissue was already more organized with presence of collagen fibers in all materials. After 15 days it was found that compound Ca(OH)<sub>2</sub>+CHX+ZnO (2:1:2) showed areas with no inflammatory infiltrate.</p></sec><sec><title>Conclusion</title><p>The experimental pastes, Ca(OH)<sub>2</sub>+CHX+ZnO in two different proportions (2:1:2) and (2:1:3), showed favorable results with respect to biocompatibility, when evaluated for a short-term.</p></sec>

Ten-year follow-up after immediate management of multiple sports‐related dental injuries: a case report

“…25 Thus, tooth 21 was treated endodontically up to the root fracture line 12 and filled only with an obturation paste composed of calcium hydroxide P.A., 2% chlorhexidine, and zinc oxide. 16 This paste has antibacterial properties; 26 is biocompatible, 27 and acts as a physical barrier, helping seal root canals. 28 It was originally proposed as a treatment for avulsed teeth but currently is equally used in the apexification of teeth with open apex 28,30,31 and the treatment of horizontal root fractures, with satisfac-tory results.…”

Medicação intracanal sem trocas periódicas como tratamento de dente avulsionado: relato de caso

“…Não há relatos na literatura da utilização de propilenoglicol e óxido de zinco associados ao hidróxido de cálcio, todavia diversos autores citam o emprego da associação de hidróxido de cálcio à clorexidina gel a 2% e óxido de zinco como uma pasta temporária que permanece no canal radicular por longos períodos, sem a necessidade de trocas constantes, e atua na inibição da reabsorção radicular externa 26,29,41 . Após algumas semanas, é provável que apenas o óxido de zinco esteja presente já que o hidróxido de cálcio sofre completa dissolução com o passar do tempo 42 .…”